[Term]
id: PR:000047449
name: fibroblast growth factor receptor substrate 2, initiator methionine removed phosphorylated 2 (human)
def: "A fibroblast growth factor receptor substrate 2 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at positions 132, 135, 138, 376, 452, 455, 458 and 463 of the amino acid sequence represented by UniProtKB:Q8WU20. UniProtKB:Q8WU20, 2-508, Thr-132/Thr-135/Thr-138/Thr-376/Thr-452/Thr-455/Thr-458/Thr-463, MOD:00047." [PRO:DNx, Reactome:R-HSA-1270462]
comment: Category=organism-modification.
synonym: "hFRS2/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000087344, Thr-132/Thr-135/Thr-138/Thr-376/Thr-452/Thr-455/Thr-458/Thr-463, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q8WU20, 2-508, Thr-132/Thr-135/Thr-138/Thr-376/Thr-452/Thr-455/Thr-458/Thr-463, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-1270462 "PR:000047449 located_in GO:0005886"
is_a: PR:Q8WU20 ! fibroblast growth factor receptor substrate 2 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000047448
name: fibroblast growth factor receptor substrate 2, initiator methionine removed form (human)
def: "A fibroblast growth factor receptor substrate 2 (human) that has had the initiator methionine removed. UniProtKB:Q8WU20, 2-508." [PRO:DNx, Reactome:R-HSA-190054]
comment: Category=organism-modification.
synonym: "PRO_0000087344" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hFRS2/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q8WU20, 2-508" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-190054 "PR:000047448 located_in GO:0005768"
xref: Reactome:R-HSA-190244 "PR:000047448 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:Q8WU20 ! fibroblast growth factor receptor substrate 2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8WU20
name: fibroblast growth factor receptor substrate 2 (human)
def: "A fibroblast growth factor receptor substrate 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8WU20]
comment: Category=organism-gene.
synonym: "FRS2" RELATED Gene-based [UniProtKB:Q8WU20]
synonym: "hFRS2" EXACT PRO-short-label [PRO:DNx]
synonym: "SNT-1 (human)" EXACT [UniProtKB:Q8WU20]
synonym: "FGFR substrate 2 (human)" EXACT [UniProtKB:Q8WU20]
synonym: "FGFR-signaling adaptor SNT (human)" EXACT [UniProtKB:Q8WU20]
synonym: "Suc1-associated neurotrophic factor target 1 (human)" EXACT [UniProtKB:Q8WU20]
xref: Reactome:R-HSA-170963 "PR:Q8WU20 located_in GO:0005886"
xref: UniProtKB:Q8WU20
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000007670 ! fibroblast growth factor receptor substrate 2
relationship: has_gene_template HGNC:16971 ! FRS2 (human)

[Term]
id: PR:Q8WU20-1
name: fibroblast growth factor receptor substrate 2 isoform 1 (human)
def: "A fibroblast growth factor receptor substrate 2 isoform 1 that is encoded in the genome of human." [PRO:CNx]
comment: Category=organism-sequence.
synonym: "hFRS2/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8WU20-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026207 ! fibroblast growth factor receptor substrate 2 isoform 1

[Term]
id: PR:000026214
name: fibroblast growth factor receptor substrate 2, initiator methionine removed phosphorylated 1 (human)
def: "A fibroblast growth factor receptor substrate 2, initiator methionine removed phosphorylated 1 in human. UniProtKB:Q8WU20, 2-508, Tyr-196/Tyr-306/Tyr-349/Tyr-392/Tyr-436/Tyr-471, MOD:00048." [PRO:CNx, PRO:DAN, Reactome:R-HSA-170959, Reactome:R-HSA-190062]
comment: Category=organism-modification.
synonym: "hFRS2/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000087344, Tyr-196/Tyr-306/Tyr-349/Tyr-392/Tyr-436/Tyr-471, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q8WU20, 2-508, Tyr-196/Tyr-306/Tyr-349/Tyr-392/Tyr-436/Tyr-471, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-170959 "PR:000026214 located_in GO:0005886"
xref: Reactome:R-HSA-190062 "PR:000026214 located_in GO:0005768"
xref: Reactome:R-HSA-190355 "PR:000026214 located_in GO:0005829"
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026209 ! fibroblast growth factor receptor substrate 2, initiator methionine removed phosphorylated 1
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine

[Term]
id: PR:000007670
name: fibroblast growth factor receptor substrate 2
def: "A protein that is a translation product of the human FRS2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "FRS2" EXACT PRO-short-label [PRO:DNx]
synonym: "Frs2a" RELATED Gene-based []
synonym: "SNT-1" EXACT []
synonym: "FRS2-alpha" EXACT []
synonym: "FGFR substrate 2" EXACT []
synonym: "FGFR-signaling adaptor SNT" EXACT []
synonym: "suc1-associated neurotrophic factor target 1" EXACT []
is_a: PR:000000001 ! protein