[Term] id: PR:Q9UQC2 name: GRB2-associated-binding protein 2 (human) def: "A GRB2-associated-binding protein 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9UQC2] comment: Category=organism-gene. synonym: "GAB2" RELATED Gene-based [UniProtKB:Q9UQC2] synonym: "hGAB2" EXACT PRO-short-label [PRO:DNx] synonym: "KIAA0571" RELATED Gene-based [UniProtKB:Q9UQC2] synonym: "pp100 (human)" EXACT [UniProtKB:Q9UQC2] synonym: "GRB2-associated binder 2 (human)" EXACT [UniProtKB:Q9UQC2] synonym: "growth factor receptor bound protein 2-associated protein 2 (human)" EXACT [UniProtKB:Q9UQC2] xref: Reactome:R-HSA-508239 "PR:Q9UQC2 located_in GO:0005829" xref: UniProtKB:Q9UQC2 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000007754 ! GRB2-associated-binding protein 2 relationship: has_gene_template HGNC:14458 ! GAB2 (human) [Term] id: PR:000007754 name: GRB2-associated-binding protein 2 def: "A protein that is a translation product of the human GAB2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "GAB2" EXACT PRO-short-label [PRO:DNx] synonym: "pp100" EXACT [] synonym: "KIAA0571" RELATED Gene-based [] synonym: "GRB2-associated binder 2" EXACT [] synonym: "PH domain-containing adaptor molecule p97" EXACT [] synonym: "growth factor receptor bound protein 2-associated protein 2" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:000046093 name: GRB2-associated-binding protein 2 phosphorylated 1 (human) def: "A GRB2-associated-binding protein 2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-159 of the amino acid sequence represented by UniProtKB:Q9UQC2-1. Example: UniProtKB:Q9UQC2-1, Ser-159, MOD:00046." [PMID:11782427, iPTMnet:Q9UQC2] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:11782427). Status=unreviewed. synonym: "hGAB2/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q9UQC2-1, Ser-159, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:Q9UQC2 ! GRB2-associated-binding protein 2 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000047488 name: GRB2-associated-binding protein 2 phosphotyrosine form (human) def: "A GRB2-associated-binding protein 2 (human) that includes at least one phosphorylated tyrosine. UniProtKB:Q9UQC2, MOD:00048." [PRO:DNx, Reactome:R-HSA-912529] comment: Category=organism-modification. synonym: "hGAB2/PhosTyr+" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q9UQC2, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-912529 "PR:000047488 located_in GO:0005829" intersection_of: has_part MOD:00048 ! O4'-phospho-L-tyrosine intersection_of: PR:Q9UQC2 ! GRB2-associated-binding protein 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q9UQC2-2 name: GRB2-associated-binding protein 2 isoform h2 (human) def: "A GRB2-associated-binding protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UQC2-2." [PRO:DNx, UniProtKB:Q9UQC2] comment: Category=organism-sequence. synonym: "hGAB2/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9UQC2-2 is_a: PR:Q9UQC2 ! GRB2-associated-binding protein 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000047487 name: GRB2-associated-binding protein 2 phosphorylated 3 (human) def: "A GRB2-associated-binding protein 2 (human) that has been post-translationally modified to include phosphotyrosine at positions 452, 476, 584, 614 and 643 of the amino acid sequence represented by UniProtKB:Q9UQC2. UniProtKB:Q9UQC2, Tyr-452/Tyr-476/Tyr-584/Tyr-614/Tyr-643, MOD:00048." [PRO:DNx, Reactome:R-HSA-8855574] comment: Category=organism-modification. synonym: "hGAB2/Phos:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q9UQC2, Tyr-452/Tyr-476/Tyr-584/Tyr-614/Tyr-643, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-8855574 "PR:000047487 located_in GO:0005829" is_a: PR:Q9UQC2 ! GRB2-associated-binding protein 2 (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000047486 name: GRB2-associated-binding protein 2 phosphorylated 2 (human) def: "A GRB2-associated-binding protein 2 (human) that has been post-translationally modified to include phosphotyrosine at positions 452, 476 and 584 of the amino acid sequence represented by UniProtKB:Q9UQC2. UniProtKB:Q9UQC2, Tyr-452/Tyr-476/Tyr-584, MOD:00048." [PRO:DNx, Reactome:R-HSA-2685615] comment: Category=organism-modification. synonym: "hGAB2/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q9UQC2, Tyr-452/Tyr-476/Tyr-584, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-2685615 "PR:000047486 located_in GO:0005829" is_a: PR:Q9UQC2 ! GRB2-associated-binding protein 2 (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q9UQC2-1 name: GRB2-associated-binding protein 2 isoform h1 (human) def: "A GRB2-associated-binding protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9UQC2-1." [PRO:DNx, UniProtKB:Q9UQC2] comment: Category=organism-sequence. synonym: "hGAB2/iso:h1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9UQC2-1 is_a: PR:Q9UQC2 ! GRB2-associated-binding protein 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens