[Term]
id: PR:000020061
name: progranulin, signal peptide removed form
def: "A progranulin that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "GRN/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000008271 ! progranulin
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000020062
name: progranulin proteolytic cleavage product
def: "A progranulin that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "GRN/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000008271 ! progranulin

[Term]
id: PR:P23785
name: progranulin (rat)
def: "A progranulin that is encoded in the genome of rat." [PANTHER:PTHR12274:SF0, PRO:DNx]
comment: Category=organism-gene.
synonym: "Grn" RELATED Gene-based [UniProtKB:P23785]
synonym: "rGRN" EXACT PRO-short-label [PRO:DNx]
synonym: "PEPI (rat)" EXACT [UniProtKB:P23785]
synonym: "PGRN (rat)" EXACT [UniProtKB:P23785]
synonym: "acrogranin (rat)" EXACT [UniProtKB:P23785]
synonym: "proepithelin (rat)" EXACT [UniProtKB:P23785]
synonym: "granulin precursor (rat)" EXACT [UniProtKB:P23785]
synonym: "epithelin precursor (rat)" EXACT [UniProtKB:P23785]
xref: UniProtKB:P23785
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000008271 ! progranulin
relationship: has_gene_template RGD:61983 ! Grn (rat)

[Term]
id: PR:000008271
name: progranulin
def: "A protein that is a translation product of the human GRN gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "GRN" EXACT PRO-short-label [PRO:DNx]
synonym: "GP88" EXACT []
synonym: "PEPI" EXACT []
synonym: "PGRN" EXACT []
synonym: "PCDGF" EXACT []
synonym: "granulins" EXACT []
synonym: "acrogranin" EXACT []
synonym: "proepithelin" EXACT []
synonym: "preprogranulin" EXACT []
synonym: "glycoprotein 88" EXACT []
synonym: "glycoprotein of 88 Kda" EXACT []
synonym: "PC cell-derived growth factor" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:P28799
name: progranulin (human)
def: "A progranulin that is encoded in the genome of human." [PRO:DNx, UniProtKB:P28799]
comment: Category=organism-gene.
synonym: "GRN" RELATED Gene-based [UniProtKB:P28799]
synonym: "hGRN" EXACT PRO-short-label [PRO:DNx]
synonym: "GP88 (human)" EXACT [UniProtKB:P28799]
synonym: "PEPI (human)" EXACT [UniProtKB:P28799]
synonym: "PGRN (human)" EXACT [UniProtKB:P28799]
synonym: "PCDGF (human)" EXACT [UniProtKB:P28799]
synonym: "acrogranin (human)" EXACT [UniProtKB:P28799]
synonym: "proepithelin (human)" EXACT [UniProtKB:P28799]
synonym: "glycoprotein 88 (human)" EXACT [UniProtKB:P28799]
synonym: "granulin precursor (human)" EXACT [UniProtKB:P28799]
synonym: "epithelin precursor (human)" EXACT [UniProtKB:P28799]
synonym: "glycoprotein of 88 Kda (human)" EXACT [UniProtKB:P28799]
synonym: "PC cell-derived growth factor (human)" EXACT [UniProtKB:P28799]
xref: UniProtKB:P28799
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008271 ! progranulin
relationship: has_gene_template HGNC:4601 ! GRN (human)

[Term]
id: PR:P28798
name: progranulin (mouse)
def: "A progranulin that is encoded in the genome of mouse." [OMA:P28798, PRO:DNx]
comment: Category=organism-gene.
synonym: "Grn" RELATED Gene-based [UniProtKB:P28798]
synonym: "mGRN" EXACT PRO-short-label [PRO:DNx]
synonym: "GP88 (mouse)" EXACT [UniProtKB:P28798]
synonym: "PEPI (mouse)" EXACT [UniProtKB:P28798]
synonym: "PGRN (mouse)" EXACT [UniProtKB:P28798]
synonym: "PCDGF (mouse)" EXACT [UniProtKB:P28798]
synonym: "acrogranin (mouse)" EXACT [UniProtKB:P28798]
synonym: "proepithelin (mouse)" EXACT [UniProtKB:P28798]
synonym: "glycoprotein 88 (mouse)" EXACT [UniProtKB:P28798]
synonym: "glycoprotein of 88 Kda (mouse)" EXACT [UniProtKB:P28798]
synonym: "epithelin/granulin precursor (mouse)" EXACT [UniProtKB:P28798]
synonym: "PC cell-derived growth factor (mouse)" EXACT [UniProtKB:P28798]
xref: UniProtKB:P28798
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000008271 ! progranulin
relationship: has_gene_template MGI:95832 ! Grn (mouse)

[Term]
id: PR:P28799-3
name: progranulin isoform h3 (human)
def: "A progranulin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28799-3." [PRO:DAN, UniProtKB:P28799]
comment: Category=organism-sequence.
synonym: "hGRN/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P28799-3
is_a: PR:P28799 ! progranulin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P28799-2
name: progranulin isoform h2 (human)
def: "A progranulin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28799-2." [PRO:DAN, UniProtKB:P28799]
comment: Category=organism-sequence.
synonym: "hGRN/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P28799-2
is_a: PR:P28799 ! progranulin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P28799-1
name: progranulin isoform h1 (human)
def: "A progranulin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P28799-1." [PRO:DAN, UniProtKB:P28799]
comment: Category=organism-sequence.
synonym: "hGRN/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P28799-1
is_a: PR:P28799 ! progranulin (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045735
name: progranulin phosphorylated 1 (human)
def: "A progranulin (human) that has been phosphorylated on the residue at the position equivalent to Ser-81 of the amino acid sequence represented by UniProtKB:P28799-1. Example: UniProtKB:P28799-1, Ser-81, MOD:00046." [PMID:26005049, iPTMnet:P28799]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:26005049). Status=unreviewed.
synonym: "hGRN/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P28799-1, Ser-81, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P28799 ! progranulin (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens