[Term]
id: PR:000008288
name: glycogen synthase kinase-3 beta
def: "A glycogen synthase kinase 3 that is a translation product of the human GSK3B gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "GSK3B" EXACT PRO-short-label [PRO:DNx]
synonym: "GSK-3 beta" EXACT []
synonym: "serine/threonine-protein kinase GSK3B" EXACT []
xref: IUPHARobj:2030
is_a: PR:000050019 ! glycogen synthase kinase 3

[Term]
id: PR:P49841
name: glycogen synthase kinase-3 beta (human)
def: "A glycogen synthase kinase-3 beta that is encoded in the genome of human." [PRO:DNx, UniProtKB:P49841]
comment: Category=organism-gene.
synonym: "GSK3B" RELATED Gene-based [UniProtKB:P49841]
synonym: "hGSK3B" EXACT PRO-short-label [PRO:DNx]
synonym: "GSK-3 beta (human)" EXACT [UniProtKB:P49841]
synonym: "serine/threonine-protein kinase GSK3B (human)" EXACT [UniProtKB:P49841]
xref: Reactome:R-HSA-2022823 "PR:P49841 located_in GO:0005654"
xref: Reactome:R-HSA-2997551 "PR:P49841 located_in GO:0005829"
xref: DTO:03100165
xref: UniProtKB:P49841
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008288 ! glycogen synthase kinase-3 beta
relationship: has_gene_template HGNC:4617 ! GSK3B (human)

[Term]
id: PR:000047635
name: glycogen synthase kinase-3 beta phosphorylated 2 (human)
def: "A glycogen synthase kinase-3 beta (human) that has been phosphorylated on the residue at the position equivalent to Ser-9 of the amino acid sequence represented by UniProtKB:P49841. UniProtKB:P49841, Ser-9, MOD:00046." [PRO:DNx, Reactome:R-HSA-3149577]
comment: Category=organism-modification.
synonym: "hGSK3B/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P49841, Ser-9, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3149577 "PR:000047635 located_in GO:0005829"
is_a: PR:P49841 ! glycogen synthase kinase-3 beta (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P49841-2
name: glycogen synthase kinase-3 beta isoform h2 (human)
def: "A glycogen synthase kinase-3 beta (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P49841-2." [PRO:DNx, UniProtKB:P49841]
comment: Category=organism-sequence.
synonym: "hGSK3B/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "glycogen synthase kinase-3 beta isoform GSK-3beta2 (human)" EXACT [UniProtKB:P49841]
synonym: "glycogen synthase kinase-3 beta isoform neuron-specific (human)" EXACT [UniProtKB:P49841]
xref: UniProtKB:P49841-2
is_a: PR:P49841 ! glycogen synthase kinase-3 beta (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P49841-1
name: glycogen synthase kinase-3 beta isoform 1 (human)
def: "A glycogen synthase kinase-3 beta isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hGSK3B/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P49841-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039611 ! glycogen synthase kinase-3 beta isoform 1

[Term]
id: PR:000045809
name: glycogen synthase kinase-3 beta phosphorylated 1 (human)
def: "A glycogen synthase kinase-3 beta (human) that has been phosphorylated on the residue at the position equivalent to Tyr-216 of the amino acid sequence represented by UniProtKB:P49841-1. Example: UniProtKB:P49841-1, Tyr-216, MOD:00048." [PMID:15020233, PMID:17188038, iPTMnet:P49841]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:15020233, PMID:17188038). Status=unreviewed.
synonym: "hGSK3B/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P49841-1, Tyr-216, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P49841 ! glycogen synthase kinase-3 beta (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens