[Term]
id: PR:000027802
name: heart- and neural crest derivatives-expressed protein 1 isoform 1 unphosphorylated form (mouse)
def: "A heart- and neural crest derivatives-expressed protein 1 isoform 1 unphosphorylated form in mouse." [PMID:17891141, PRO:HJD]
comment: Category=organism-modification.
synonym: "mHAND1/iso:1/PhosRes-" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000027801 ! heart- and neural crest derivatives-expressed protein 1 isoform 1 unphosphorylated form

[Term]
id: PR:000027801
name: heart- and neural crest derivatives-expressed protein 1 isoform 1 unphosphorylated form
def: "A heart- and neural crest derivatives-expressed protein 1 isoform 1 that lacks phosphorylated residues." [PRO:CNA]
comment: Category=modification.
synonym: "HAND1/iso:1/PhosRes-" EXACT PRO-short-label [PRO:DNx]
intersection_of: lacks_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000027797 ! heart- and neural crest derivatives-expressed protein 1 isoform 1

[Term]
id: PR:000027800
name: heart- and neural crest derivatives-expressed protein 1 isoform 1 phosphorylated 1 (mouse)
def: "A heart- and neural crest derivatives-expressed protein 1 isoform 1 phosphorylated 1 in mouse. This phosphorylation is required for nucleolar release. UniProtKB:Q64279-1, (Thr-107, MOD:00047 and/or Ser-109, MOD:00046)." [PMID:17891141, PRO:HJD]
comment: Category=organism-modification. Kinase=("PLK4"; PR:Q64702). It is not clear whether phosphorylation is at either one site or two sites.
synonym: "mHAND1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q64279-1, (Thr-107, MOD:00047 and/or Ser-109, MOD:00046)" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000027799 ! heart- and neural crest derivatives-expressed protein 1 isoform 1 phosphorylated 1
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:Q64279-1
name: heart- and neural crest derivatives-expressed protein 1 isoform 1 (mouse)
def: "A heart- and neural crest derivatives-expressed protein 1 isoform 1 that is encoded in the genome of mouse." [PMID:7791788, PRO:CNA]
comment: Category=organism-sequence.
synonym: "mHAND1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q64279-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000027797 ! heart- and neural crest derivatives-expressed protein 1 isoform 1

[Term]
id: PR:000027799
name: heart- and neural crest derivatives-expressed protein 1 isoform 1 phosphorylated 1
def: "A heart- and neural crest derivatives-expressed protein 1 isoform 1 that has been phosphorylated at the Ser and/or Thr residues within the KER[RQ]RTxS motif located at the N terminus of the bHLH domain. Example: UniProtKB:Q64279-1, (Thr-107, MOD:00047 and/or Ser-109, MOD:00046)." [PMID:17891141, PRO:HJD]
comment: Category=modification.
synonym: "HAND1/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000027797 ! heart- and neural crest derivatives-expressed protein 1 isoform 1
relationship: has_part MOD:00696 ! phosphorylated residue

[Term]
id: PR:O96004
name: heart- and neural crest derivatives-expressed protein 1 (human)
def: "A heart- and neural crest derivatives-expressed protein 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O96004]
comment: Category=organism-gene.
synonym: "EHAND" RELATED Gene-based [UniProtKB:O96004]
synonym: "HAND1" RELATED Gene-based [UniProtKB:O96004]
synonym: "hHAND1" EXACT PRO-short-label [PRO:DNx]
synonym: "BHLHA27" RELATED Gene-based [UniProtKB:O96004]
synonym: "class A basic helix-loop-helix protein 27 (human)" EXACT [UniProtKB:O96004]
synonym: "extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1 (human)" EXACT [UniProtKB:O96004]
xref: UniProtKB:O96004
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008439 ! heart- and neural crest derivatives-expressed protein 1
relationship: has_gene_template HGNC:4807 ! HAND1 (human)

[Term]
id: PR:000027797
name: heart- and neural crest derivatives-expressed protein 1 isoform 1
def: "A heart- and neural crest derivatives-expressed protein 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q64279-1 or a 1:1 ortholog thereof." [PMID:17891141, PMID:7791788, PRO:CNA]
comment: Category=sequence.
synonym: "HAND1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000008439 ! heart- and neural crest derivatives-expressed protein 1

[Term]
id: PR:P97832
name: heart- and neural crest derivatives-expressed protein 1 (rat)
def: "A heart- and neural crest derivatives-expressed protein 1 that is encoded in the genome of rat." [OMA:P97832, PRO:DNx]
comment: Category=organism-gene.
synonym: "Ehand" RELATED Gene-based [UniProtKB:P97832]
synonym: "Hand1" RELATED Gene-based [UniProtKB:P97832]
synonym: "rHAND1" EXACT PRO-short-label [PRO:DNx]
synonym: "eHAND (rat)" EXACT [UniProtKB:P97832]
synonym: "extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1 (rat)" EXACT [UniProtKB:P97832]
xref: UniProtKB:P97832
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000008439 ! heart- and neural crest derivatives-expressed protein 1
relationship: has_gene_template RGD:621206 ! Hand1 (rat)

[Term]
id: PR:O96004-1
name: heart- and neural crest derivatives-expressed protein 1 isoform 1 (human)
def: "A heart- and neural crest derivatives-expressed protein 1 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hHAND1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O96004-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000027797 ! heart- and neural crest derivatives-expressed protein 1 isoform 1

[Term]
id: PR:000008439
name: heart- and neural crest derivatives-expressed protein 1
def: "A basic helix-loop-helix transcription factor HAND that is a translation product of the human HAND1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "Hxt" RELATED Gene-based []
synonym: "Th1" EXACT []
synonym: "EHAND" RELATED Gene-based []
synonym: "HAND1" EXACT PRO-short-label [PRO:DNx]
synonym: "eHAND" EXACT []
synonym: "Thing1" RELATED Gene-based []
synonym: "BHLHA27" RELATED Gene-based []
synonym: "bHLHa27" EXACT []
synonym: "thing-1" EXACT []
synonym: "class A basic helix-loop-helix protein 27" EXACT []
synonym: "helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast" EXACT []
synonym: "extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1" EXACT []
is_a: PR:000027804 ! basic helix-loop-helix transcription factor HAND

[Term]
id: PR:Q64279
name: heart- and neural crest derivatives-expressed protein 1 (mouse)
def: "A heart- and neural crest derivatives-expressed protein 1 that is encoded in the genome of mouse." [OMA:Q64279, PRO:DNx]
comment: Category=organism-gene.
synonym: "Hxt" RELATED Gene-based [UniProtKB:Q64279]
synonym: "Ehand" RELATED Gene-based [UniProtKB:Q64279]
synonym: "Hand1" RELATED Gene-based [UniProtKB:Q64279]
synonym: "Thing1" RELATED Gene-based [UniProtKB:Q64279]
synonym: "mHAND1" EXACT PRO-short-label [PRO:DNx]
synonym: "Th1 (mouse)" RELATED [UniProtKB:Q64279]
synonym: "eHAND (mouse)" EXACT [UniProtKB:Q64279]
synonym: "thing-1 (mouse)" EXACT [UniProtKB:Q64279]
synonym: "helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast (mouse)" EXACT [UniProtKB:Q64279]
synonym: "extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1 (mouse)" EXACT [UniProtKB:Q64279]
xref: UniProtKB:Q64279
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000008439 ! heart- and neural crest derivatives-expressed protein 1
relationship: has_gene_template MGI:103577 ! Hand1 (mouse)

[Term]
id: PR:P97832-1
name: heart- and neural crest derivatives-expressed protein 1 isoform 1 (rat)
def: "A heart- and neural crest derivatives-expressed protein 1 isoform 1 that is encoded in the genome of rat." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "rHAND1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P97832-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000027797 ! heart- and neural crest derivatives-expressed protein 1 isoform 1