[Term]
id: PR:Q16665-1
name: hypoxia-inducible factor 1-alpha isoform 1 (human)
def: "A hypoxia-inducible factor 1-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16665-1." [PRO:DNx, UniProtKB:Q16665]
comment: Category=organism-sequence. Requested by=PubChem.
synonym: "hHIF1A/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q16665-1
is_a: PR:Q16665 ! hypoxia-inducible factor 1-alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q16665-3
name: hypoxia-inducible factor 1-alpha isoform h3 (human)
def: "A hypoxia-inducible factor 1-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16665-3." [PRO:DNx, UniProtKB:Q16665]
comment: Category=organism-sequence.
synonym: "hHIF1A/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "hypoxia-inducible factor 1-alpha isoform I.3 (human)" EXACT [UniProtKB:Q16665]
xref: UniProtKB:Q16665-3
is_a: PR:Q16665 ! hypoxia-inducible factor 1-alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q16665-2
name: hypoxia-inducible factor 1-alpha isoform h2 (human)
def: "A hypoxia-inducible factor 1-alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16665-2." [PRO:DNx, UniProtKB:Q16665]
comment: Category=organism-sequence.
synonym: "hHIF1A/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q16665-2
is_a: PR:Q16665 ! hypoxia-inducible factor 1-alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045960
name: hypoxia-inducible factor 1-alpha phosphorylated 1 (human)
def: "A hypoxia-inducible factor 1-alpha (human) that has been phosphorylated on the residue at the position equivalent to Ser-247 of the amino acid sequence represented by UniProtKB:Q16665-1. Example: UniProtKB:Q16665-1, Ser-247, MOD:00046." [PMID:20699359, iPTMnet:Q16665]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:20699359). Status=unreviewed.
synonym: "hHIF1A/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q16665-1, Ser-247, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q16665 ! hypoxia-inducible factor 1-alpha (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000008555
name: hypoxia-inducible factor 1-alpha
def: "A protein that is a translation product of the human HIF1A gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MOP1" RELATED Gene-based []
synonym: "HIF1A" EXACT PRO-short-label [PRO:DNx]
synonym: "PASD8" RELATED Gene-based []
synonym: "BHLHE78" RELATED Gene-based []
synonym: "bHLHe78" EXACT []
synonym: "HIF1-alpha" EXACT []
synonym: "HIF-1-alpha" EXACT []
synonym: "member of PAS protein 1" EXACT []
synonym: "ARNT-interacting protein" RELATED []
synonym: "PAS domain-containing protein 8" EXACT []
synonym: "basic-helix-loop-helix-PAS protein MOP1" EXACT []
synonym: "class E basic helix-loop-helix protein 78" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000047696
name: hypoxia-inducible factor 1-alpha phosphorylated 2 (human)
def: "A hypoxia-inducible factor 1-alpha (human) that has been phosphorylated on the residue at the position equivalent to Tyr-565, and phosphoserine at position 797 of the amino acid sequence represented by UniProtKB:Q16665. UniProtKB:Q16665, Tyr-565, MOD:00048|Ser-797, MOD:00046." [PRO:DNx, Reactome:R-HSA-9634700]
comment: Category=organism-modification.
synonym: "hHIF1A/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q16665, Tyr-565, MOD:00048|Ser-797, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-9634700 "PR:000047696 located_in GO:0005829"
is_a: PR:Q16665 ! hypoxia-inducible factor 1-alpha (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q16665
name: hypoxia-inducible factor 1-alpha (human)
def: "A hypoxia-inducible factor 1-alpha that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q16665]
comment: Category=organism-gene.
synonym: "MOP1" RELATED Gene-based [UniProtKB:Q16665]
synonym: "HIF1A" RELATED Gene-based [UniProtKB:Q16665]
synonym: "PASD8" RELATED Gene-based [UniProtKB:Q16665]
synonym: "hHIF1A" EXACT PRO-short-label [PRO:DNx]
synonym: "BHLHE78" RELATED Gene-based [UniProtKB:Q16665]
synonym: "HIF1-alpha (human)" EXACT [UniProtKB:Q16665]
synonym: "HIF-1-alpha (human)" EXACT [UniProtKB:Q16665]
synonym: "member of PAS protein 1 (human)" EXACT [UniProtKB:Q16665]
synonym: "ARNT-interacting protein (human)" EXACT [UniProtKB:Q16665]
synonym: "PAS domain-containing protein 8 (human)" EXACT [UniProtKB:Q16665]
synonym: "basic-helix-loop-helix-PAS protein MOP1 (human)" EXACT [UniProtKB:Q16665]
synonym: "class E basic helix-loop-helix protein 78 (human)" EXACT [UniProtKB:Q16665]
xref: Reactome:R-HSA-1234102 "PR:Q16665 located_in GO:0005829"
xref: Reactome:R-HSA-1234135 "PR:Q16665 located_in GO:0005654"
xref: UniProtKB:Q16665
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000008555 ! hypoxia-inducible factor 1-alpha
relationship: has_gene_template HGNC:4910 ! HIF1A (human)