[Term] id: PR:000045083 name: histone H2B type 1-K, initiator methionine removed ubiquitinated 1 (human) def: "A histone H2B type 1-K (human) that has had the initiator methionine removed and that has been ubiquitinated on the lysine at the position equivalent to Lys-121 of the amino acid sequence represented by UniProtKB:O60814. UniProtKB:O60814, 2-126, Lys-121, MOD:01148." [HIstome_var_Hs:Histone_H2B_type_1-K, PMID:16307923, PMID:16713563, PMID:18400894, PMID:18832071, PMID:18923072, PMID:19575011, PRO:DAN, PRO:JPB, PRO:JR] comment: Category=organism-modification. Note: A correction of the sequence numbering of the source data (Reactome:R-HSA-6782548) rendered PR:000047795 identical to this entry. synonym: "H2B_type_1-K:H2BK120ub" BROAD [HIstome_ptm_Hs:H2BK120ub] synonym: "hHIST1H2BK/InitMet-/Ubiq:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000071828, Lys-121, MOD:01148" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:O60814, 2-126, Lys-121, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-3364019 "PR:000045083 located_in GO:0005654" is_a: PR:O60814 ! histone H2B type 1-K (human) relationship: has_part MOD:01148 ! ubiquitinylated lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000045082 name: histone H2B type 1-K, initiator methionine removed ADP-ribosylated 1 (human) def: "A histone H2B type 1-K (human) that has had the initiator methionine removed and that has been ADP-ribosylated at the position equivalent to Lys-31 of the amino acid sequence represented by UniProtKB:O60814. UniProtKB:O60814, 2-126, Lys-31, MOD:01399." [HIstome_var_Hs:Histone_H2B_type_1-K, PMID:20525793, PRO:DAN, PRO:JPB, PRO:JR] comment: Category=organism-modification. synonym: "H2B_type_1-K:H2BK30ar" BROAD [HIstome_ptm_Hs:H2BK30ar] synonym: "hHIST1H2BK/InitMet-/ADPrib:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000071828, Lys-31, MOD:01399" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:O60814, 2-126, Lys-31, MOD:01399" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:O60814 ! histone H2B type 1-K (human) relationship: has_part MOD:01399 ! N6-(ADP-ribosyl)-L-lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000045081 name: histone H2B type 1-K, initiator methionine removed acetylated 2 (human) def: "A histone H2B type 1-K (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-21 of the amino acid sequence represented by UniProtKB:O60814. UniProtKB:O60814, 2-126, Lys-21, MOD:00064." [HIstome_var_Hs:Histone_H2B_type_1-K, PMID:16283522, PMID:18552846, PRO:DAN, PRO:JPB, PRO:JR] comment: Category=organism-modification. synonym: "H2B_type_1-K:H2BK20ac" BROAD [HIstome_ptm_Hs:H2BK20ac] synonym: "hHIST1H2BK/InitMet-/Ac:2" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000071828, Lys-21, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:O60814, 2-126, Lys-21, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-4568711 "PR:000045081 located_in GO:0005654" is_a: PR:O60814 ! histone H2B type 1-K (human) relationship: has_part MOD:00064 ! N6-acetyl-L-lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000008591 name: histone H2B type 1-K def: "A histone H2B that is a translation product of the human H2BC12 gene or a 1:1 ortholog thereof." [PRO:DAN] comment: Category=gene. synonym: "H2B K" EXACT [] synonym: "H2BFT" RELATED Gene-based [] synonym: "H2BC12" EXACT PRO-short-label [PRO:DNx] synonym: "HIRIP1" RELATED Gene-based [] synonym: "HIST1H2BK" RELATED Gene-based [] synonym: "HIRA-interacting protein 1" EXACT [] is_a: PR:000036509 ! histone H2B [Term] id: PR:000045087 name: histone H2B type 1-K, initiator methionine removed acetylated 5 (human) def: "A histone H2B type 1-K (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-47 of the amino acid sequence represented by UniProtKB:O60814. UniProtKB:O60814, 2-126, Lys-47, MOD:00064." [HIstome_var_Hs:Histone_H2B_type_1-K, PMID:20693536, PRO:DAN, PRO:JPB, PRO:JR] comment: Category=organism-modification. synonym: "H2B_type_1-K:H2BK46ac" BROAD [HIstome_ptm_Hs:H2BK46ac] synonym: "hHIST1H2BK/InitMet-/Ac:5" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000071828, Lys-47, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:O60814, 2-126, Lys-47, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:O60814 ! histone H2B type 1-K (human) relationship: has_part MOD:00064 ! N6-acetyl-L-lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000045086 name: histone H2B type 1-K, initiator methionine removed monomethylated 1 (human) def: "A histone H2B type 1-K (human) that has had the initiator methionine removed and that has been monomethylated at the position equivalent to Lys-6 of the amino acid sequence represented by UniProtKB:O60814. UniProtKB:O60814, 2-126, Lys-6, MOD:00085." [HIstome_var_Hs:Histone_H2B_type_1-K, PMID:17512414, PRO:DAN, PRO:JPB, PRO:JR] comment: Category=organism-modification. synonym: "H2B_type_1-K:H2BK5me1" BROAD [HIstome_ptm_Hs:H2BK5me1] synonym: "hHIST1H2BK/InitMet-/Me1:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000071828, Lys-6, MOD:00085" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:O60814, 2-126, Lys-6, MOD:00085" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:O60814 ! histone H2B type 1-K (human) relationship: has_part MOD:00085 ! N6-methyl-L-lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000045085 name: histone H2B type 1-K, initiator methionine removed acetylated 4 (human) def: "A histone H2B type 1-K (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-6 of the amino acid sequence represented by UniProtKB:O60814. UniProtKB:O60814, 2-126, Lys-6, MOD:00064." [HIstome_var_Hs:Histone_H2B_type_1-K, PMID:18552846, PRO:DAN, PRO:JPB, PRO:JR] comment: Category=organism-modification. synonym: "H2B_type_1-K:H2BK5ac" BROAD [HIstome_ptm_Hs:H2BK5ac] synonym: "hHIST1H2BK/InitMet-/Ac:4" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000071828, Lys-6, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:O60814, 2-126, Lys-6, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-4568714 "PR:000045085 located_in GO:0005654" is_a: PR:O60814 ! histone H2B type 1-K (human) relationship: has_part MOD:00064 ! N6-acetyl-L-lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000045084 name: histone H2B type 1-K, initiator methionine removed acetylated 3 (human) def: "A histone H2B type 1-K (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-17 of the amino acid sequence represented by UniProtKB:O60814. UniProtKB:O60814, 2-126, Lys-17, MOD:00064." [HIstome_var_Hs:Histone_H2B_type_1-K, PMID:20693536, PRO:DAN, PRO:JPB, PRO:JR] comment: Category=organism-modification. synonym: "H2B_type_1-K:H2BK16ac" BROAD [HIstome_ptm_Hs:H2BK16ac] synonym: "hHIST1H2BK/InitMet-/Ac:3" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000071828, Lys-17, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:O60814, 2-126, Lys-17, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:O60814 ! histone H2B type 1-K (human) relationship: has_part MOD:00064 ! N6-acetyl-L-lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000045089 name: histone H2B type 1-K, initiator methionine removed acetylated 7 (human) def: "A histone H2B type 1-K (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-16 of the amino acid sequence represented by UniProtKB:O60814. UniProtKB:O60814, 2-126, Lys-16, MOD:00064." [HIstome_var_Hs:Histone_H2B_type_1-K, PMID:19883641, PRO:DAN, PRO:JPB, PRO:JR] comment: Category=organism-modification. synonym: "H2B_type_1-K:H2BK15ac" BROAD [HIstome_ptm_Hs:H2BK15ac] synonym: "hHIST1H2BK/InitMet-/Ac:7" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000071828, Lys-16, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:O60814, 2-126, Lys-16, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-4568717 "PR:000045089 located_in GO:0005654" is_a: PR:O60814 ! histone H2B type 1-K (human) relationship: has_part MOD:00064 ! N6-acetyl-L-lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000045088 name: histone H2B type 1-K, initiator methionine removed acetylated 6 (human) def: "A histone H2B type 1-K (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-121 of the amino acid sequence represented by UniProtKB:O60814. UniProtKB:O60814, 2-126, Lys-121, MOD:00064." [HIstome_var_Hs:Histone_H2B_type_1-K, PMID:18552846, PRO:DAN, PRO:JPB, PRO:JR] comment: Category=organism-modification. synonym: "H2B_type_1-K:H2BK120ac" BROAD [HIstome_ptm_Hs:H2BK120ac] synonym: "hHIST1H2BK/InitMet-/Ac:6" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000071828, Lys-121, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:O60814, 2-126, Lys-121, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:O60814 ! histone H2B type 1-K (human) relationship: has_part MOD:00064 ! N6-acetyl-L-lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000047793 name: obsolete histone H2B type 1-K, initiator methionine removed acetylated 4 (human) is_obsolete: true replaced_by: PR:000045085 [Term] id: PR:000047791 name: obsolete histone H2B type 1-K, initiator methionine removed acetylated 7 (human) is_obsolete: true replaced_by: PR:000045089 [Term] id: PR:000047790 name: obsolete histone H2B type 1-K, initiator methionine removed acetylated 1 (human) is_obsolete: true replaced_by: PR:000045079 [Term] id: PR:000047792 name: obsolete histone H2B type 1-K, initiator methionine removed acetylated 2 (human) is_obsolete: true replaced_by: PR:000045081 [Term] id: PR:000045080 name: histone H2B type 1-K, initiator methionine removed phosphorylated 1 (human) def: "A histone H2B type 1-K (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Ser-15 of the amino acid sequence represented by UniProtKB:O60814. UniProtKB:O60814, 2-126, Ser-15, MOD:00046." [HIstome_var_Hs:Histone_H2B_type_1-K, PMID:12757711, PRO:DAN, PRO:JPB, PRO:JR] comment: Category=organism-modification. synonym: "H2B_type_1-K:H2BS14ph" BROAD [HIstome_ptm_Hs:H2BS14ph] synonym: "hHIST1H2BK/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000071828, Ser-15, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:O60814, 2-126, Ser-15, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: TDR:13597 is_a: PR:O60814 ! histone H2B type 1-K (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000047794 name: histone H2B type 1-K, initiator methionine removed N6-acetyllysine form (human) def: "A histone H2B type 1-K (human) that has had the initiator methionine removed and that includes at least one N6-acetyllysine. UniProtKB:O60814, 2-126, MOD:00064." [PRO:DNx, Reactome:R-HSA-4549262] comment: Category=organism-modification. synonym: "PRO_0000071828, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hHIST1H2BK/InitMet-/N6AcLys+" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:O60814, 2-126, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-4549262 "PR:000047794 located_in GO:0005654" intersection_of: has_part MOD:00064 ! N6-acetyl-L-lysine intersection_of: lacks_part PR:000021937 ! initiator methionine intersection_of: PR:O60814 ! histone H2B type 1-K (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O60814 name: histone H2B type 1-K (human) def: "A histone H2B type 1-K that is encoded in the genome of human." [PRO:DNx, UniProtKB:O60814] comment: Category=organism-gene. synonym: "H2BFT" RELATED Gene-based [UniProtKB:O60814] synonym: "H2BC12" RELATED Gene-based [UniProtKB:O60814] synonym: "HIRIP1" RELATED Gene-based [UniProtKB:O60814] synonym: "hH2BC12" EXACT PRO-short-label [PRO:DNx] synonym: "HIST1H2BK" RELATED Gene-based [UniProtKB:O60814] synonym: "H2B K (human)" EXACT [UniProtKB:O60814] synonym: "HIRA-interacting protein 1 (human)" EXACT [UniProtKB:O60814] xref: UniProtKB:O60814 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000008591 ! histone H2B type 1-K relationship: has_gene_template HGNC:13954 ! H2BC12 (human) [Term] id: PR:000045079 name: histone H2B type 1-K, initiator methionine removed acetylated 1 (human) def: "A histone H2B type 1-K (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-13 of the amino acid sequence represented by UniProtKB:O60814. UniProtKB:O60814, 2-126, Lys-13, MOD:00064." [HIstome_var_Hs:Histone_H2B_type_1-K, PMID:16283522, PMID:18552846, PMID:20693536, PRO:DAN, PRO:JPB, PRO:JR] comment: Category=organism-modification. synonym: "H2B_type_1-K:H2BK12ac" BROAD [HIstome_ptm_Hs:H2BK12ac] synonym: "hHIST1H2BK/InitMet-/Ac:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000071828, Lys-13, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:O60814, 2-126, Lys-13, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-4568723 "PR:000045079 located_in GO:0005654" is_a: PR:O60814 ! histone H2B type 1-K (human) relationship: has_part MOD:00064 ! N6-acetyl-L-lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000047789 name: histone H2B type 1-K, initiator methionine removed form (human) def: "A histone H2B type 1-K (human) that has had the initiator methionine removed. UniProtKB:O60814, 2-126." [PRO:DNx, Reactome:R-HSA-181898, Reactome:R-HSA-977574] comment: Category=organism-modification. synonym: "PRO_0000071828" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hHIST1H2BK/InitMet-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:O60814, 2-126" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-181898 "PR:000047789 located_in GO:0005654" xref: Reactome:R-HSA-977574 "PR:000047789 located_in GO:0005576" xref: TDR:6972 intersection_of: lacks_part PR:000021937 ! initiator methionine intersection_of: PR:O60814 ! histone H2B type 1-K (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens