[Term] id: PR:P51639 name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase (rat) def: "A 3-hydroxy-3-methylglutaryl-coenzyme A reductase that is encoded in the genome of rat." [OMA:P51639, PANTHER:PTHR10572:SF0, PRO:DNx] comment: Category=organism-gene. synonym: "Hmgcr" RELATED Gene-based [UniProtKB:P51639] synonym: "rHMGCR" EXACT PRO-short-label [PRO:DNx] synonym: "HMG-CoA reductase (rat)" EXACT [UniProtKB:P51639] xref: UniProtKB:P51639 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000008636 ! 3-hydroxy-3-methylglutaryl-coenzyme A reductase relationship: has_gene_template RGD:2803 ! Hmgcr (rat) [Term] id: PR:000040224 name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform 1 def: "A 3-hydroxy-3-methylglutaryl-coenzyme A reductase that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q01237-1 or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=sequence. synonym: "HMGCR/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000008636 ! 3-hydroxy-3-methylglutaryl-coenzyme A reductase [Term] id: PR:P51639-1 name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform 1 (rat) def: "A 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform 1 that is encoded in the genome of rat." [PRO:DNx] comment: Category=organism-sequence. synonym: "rHMGCR/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P51639-1 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000040224 ! 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform 1 [Term] id: PR:Q01237 name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase (mouse) def: "A 3-hydroxy-3-methylglutaryl-coenzyme A reductase that is encoded in the genome of mouse." [OMA:Q01237, PRO:DNx] comment: Category=organism-gene. synonym: "Hmgcr" RELATED Gene-based [UniProtKB:Q01237] synonym: "mHMGCR" EXACT PRO-short-label [PRO:DNx] synonym: "HMG-CoA reductase (mouse)" EXACT [UniProtKB:Q01237] xref: UniProtKB:Q01237 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000008636 ! 3-hydroxy-3-methylglutaryl-coenzyme A reductase relationship: has_gene_template MGI:96159 ! Hmgcr (mouse) [Term] id: PR:Q10283 name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Schizosaccharomyces pombe 972h-) def: "A 3-hydroxy-3-methylglutaryl-coenzyme A reductase that is encoded in the genome of Schizosaccharomyces pombe 972h-." [PANTHER:PTHR10572:SF0, PRO:DNx] comment: Category=organism-gene. synonym: "hmg1" RELATED Gene-based [UniProtKB:Q10283] synonym: "its12" RELATED Gene-based [UniProtKB:Q10283] synonym: "SPCC162.09c" RELATED Gene-based [UniProtKB:Q10283] synonym: "Spom972h-HMGCR" EXACT PRO-short-label [PRO:DNx] synonym: "HMG-CoA reductase (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q10283] xref: UniProtKB:Q10283 intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h- intersection_of: PR:000008636 ! 3-hydroxy-3-methylglutaryl-coenzyme A reductase relationship: has_gene_template PomBase:SPCC162.09c ! hmg1 (Schizosaccharomyces pombe) [Term] id: PR:P14773 name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase (fruit fly) def: "A 3-hydroxy-3-methylglutaryl-coenzyme A reductase that is encoded in the genome of fruit fly." [OMA:P14773, PANTHER:PTHR10572:SF0, PRO:DNx] comment: Category=organism-gene. synonym: "Hmgcr" RELATED Gene-based [UniProtKB:P14773] synonym: "CG10367" RELATED Gene-based [UniProtKB:P14773] synonym: "HmG-CoAR" RELATED Gene-based [UniProtKB:P14773] synonym: "fly-HMGCR" EXACT PRO-short-label [PRO:DNx] synonym: "HMG-CoA reductase (fruit fly)" EXACT [UniProtKB:P14773] xref: UniProtKB:P14773 intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster intersection_of: PR:000008636 ! 3-hydroxy-3-methylglutaryl-coenzyme A reductase relationship: has_gene_template FlyBase:FBgn0263782 ! Hmgcr (fruit fly) [Term] id: PR:Q19207 name: 3-hydroxy-3-methylglutaryl coenzyme A reductase (worm) def: "A 3-hydroxy-3-methylglutaryl-coenzyme A reductase that is encoded in the genome of worm." [PANTHER:PTHR10572:SF0, PRO:DNx] comment: Category=organism-gene. synonym: "CELE_F08F8.2" RELATED Gene-based [UniProtKB:Q19207] synonym: "HMGCR (worm)" EXACT PRO-short-label [PRO:DNx] synonym: "HMG-CoA reductase (worm)" EXACT [UniProtKB:Q19207] xref: UniProtKB:Q19207 intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans intersection_of: PR:000008636 ! 3-hydroxy-3-methylglutaryl-coenzyme A reductase relationship: has_gene_template WormBase:WBGene00017268 ! hmgr-1 (worm) [Term] id: PR:P04035-1 name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform h1 (human) def: "A 3-hydroxy-3-methylglutaryl-coenzyme A reductase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04035-1." [PRO:DNx, UniProtKB:P04035] comment: Category=organism-sequence. synonym: "hHMGCR/iso:h1" EXACT PRO-short-label [PRO:DNx] xref: Reactome:R-HSA-191308 "PR:P04035-1 located_in GO:0005789" xref: UniProtKB:P04035-1 is_a: PR:P04035 ! 3-hydroxy-3-methylglutaryl-coenzyme A reductase (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P04035-2 name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform h2 (human) def: "A 3-hydroxy-3-methylglutaryl-coenzyme A reductase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04035-2." [PRO:DNx, UniProtKB:P04035] comment: Category=organism-sequence. synonym: "hHMGCR/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: Reactome:R-HSA-191426 "PR:P04035-2 located_in GO:0005789" xref: UniProtKB:P04035-2 is_a: PR:P04035 ! 3-hydroxy-3-methylglutaryl-coenzyme A reductase (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P04035-3 name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform h3 (human) def: "A 3-hydroxy-3-methylglutaryl-coenzyme A reductase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04035-3." [PRO:DNx, UniProtKB:P04035] comment: Category=organism-sequence. synonym: "hHMGCR/iso:h3" EXACT PRO-short-label [PRO:DNx] synonym: "3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform HMGCR-1b (human)" EXACT [UniProtKB:P04035] xref: UniProtKB:P04035-3 is_a: PR:P04035 ! 3-hydroxy-3-methylglutaryl-coenzyme A reductase (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P04035 name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase (human) def: "A 3-hydroxy-3-methylglutaryl-coenzyme A reductase that is encoded in the genome of human." [PRO:DNx, UniProtKB:P04035] comment: Category=organism-gene. synonym: "HMGCR" RELATED Gene-based [UniProtKB:P04035] synonym: "hHMGCR" EXACT PRO-short-label [PRO:DNx] synonym: "HMG-CoA reductase (human)" EXACT [UniProtKB:P04035] xref: Reactome:R-HSA-9621345 "PR:P04035 located_in GO:0005789" xref: UniProtKB:P04035 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000008636 ! 3-hydroxy-3-methylglutaryl-coenzyme A reductase relationship: has_gene_template HGNC:5006 ! HMGCR (human) [Term] id: PR:Q01237-1 name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform 1 (mouse) def: "A 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform 1 that is encoded in the genome of mouse." [PRO:DNx] comment: Category=organism-sequence. synonym: "mHMGCR/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q01237-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000040224 ! 3-hydroxy-3-methylglutaryl-coenzyme A reductase isoform 1 [Term] id: PR:000008636 name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase def: "A protein that is a translation product of the human HMGCR gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "HMGCR" EXACT PRO-short-label [PRO:DNx] synonym: "HMG-CoA reductase" EXACT [] xref: IUPHARobj:639 is_a: PR:000000001 ! protein