[Term]
id: PR:P35568
name: insulin receptor substrate 1 (human)
def: "An insulin receptor substrate 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P35568]
comment: Category=organism-gene.
synonym: "IRS1" RELATED Gene-based [UniProtKB:P35568]
synonym: "hIRS1" EXACT PRO-short-label [PRO:DNx]
synonym: "IRS-1 (human)" EXACT [UniProtKB:P35568]
xref: Reactome:R-HSA-74769 "PR:P35568 located_in GO:0005829"
xref: Reactome:R-HSA-2425392 "PR:P35568 located_in GO:0005886"
xref: UniProtKB:P35568
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000009107 ! insulin receptor substrate 1
relationship: has_gene_template HGNC:6125 ! IRS1 (human)

[Term]
id: PR:P35569
name: insulin receptor substrate 1 (mouse)
def: "An insulin receptor substrate 1 that is encoded in the genome of mouse." [OMA:P35569, PRO:DNx]
comment: Category=organism-gene.
synonym: "Irs1" RELATED Gene-based [UniProtKB:P35569]
synonym: "Irs-1" RELATED Gene-based [UniProtKB:P35569]
synonym: "mIRS1" EXACT PRO-short-label [PRO:DNx]
synonym: "IRS-1 (mouse)" EXACT [UniProtKB:P35569]
xref: UniProtKB:P35569
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000009107 ! insulin receptor substrate 1
relationship: has_gene_template MGI:99454 ! Irs1 (mouse)

[Term]
id: PR:000048052
name: insulin receptor substrate 1 phosphotyrosine form (human)
def: "An insulin receptor substrate 1 (human) that includes at least one phosphorylated tyrosine. UniProtKB:P35568, MOD:00048." [PRO:DNx, Reactome:R-HSA-198366, Reactome:R-HSA-74772]
comment: Category=organism-modification.
synonym: "hIRS1/PhosTyr+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P35568, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-74772 "PR:000048052 located_in GO:0005829"
xref: Reactome:R-HSA-198366 "PR:000048052 located_in GO:0005886"
intersection_of: has_part MOD:00048 ! O4'-phospho-L-tyrosine
intersection_of: PR:P35568 ! insulin receptor substrate 1 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048051
name: insulin receptor substrate 1 phosphorylated 2 (human)
def: "An insulin receptor substrate 1 (human) that has been post-translationally modified to include phosphotyrosine at positions 612, 662, 732, 896, 941 and 1179 of the amino acid sequence represented by UniProtKB:P35568. UniProtKB:P35568, Tyr-612/Tyr-662/Tyr-732/Tyr-896/Tyr-941/Tyr-1179, MOD:00048." [PRO:DNx, Reactome:R-HSA-2445090]
comment: Category=organism-modification.
synonym: "hIRS1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P35568, Tyr-612/Tyr-662/Tyr-732/Tyr-896/Tyr-941/Tyr-1179, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2445090 "PR:000048051 located_in GO:0005886"
is_a: PR:P35568 ! insulin receptor substrate 1 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000045764
name: insulin receptor substrate 1 phosphorylated 1 (human)
def: "An insulin receptor substrate 1 (human) that has been phosphorylated at Ser-794. UniProtKB:P35568, Ser-794, MOD:00046." [PMID:12624099, iPTMnet:P35568]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:12624099). Status=unreviewed.
synonym: "hIRS1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P35568, Ser-794, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P35568 ! insulin receptor substrate 1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046172
name: insulin receptor substrate 1 phosphorylated 1 (rat)
def: "An insulin receptor substrate 1 (rat) that has been phosphorylated at Ser-522. UniProtKB:P35570, Ser-522, MOD:00046." [PMID:17579213, iPTMnet:P35570]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:17579213). Status=unreviewed.
synonym: "rIRS1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P35570, Ser-522, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P35570 ! insulin receptor substrate 1 (rat)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus

[Term]
id: PR:000009107
name: insulin receptor substrate 1
def: "A protein that is a translation product of the human IRS1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "IRS1" EXACT PRO-short-label [PRO:DNx]
synonym: "IRS-1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000046171
name: insulin receptor substrate 1 phosphorylated 1 (mouse)
def: "An insulin receptor substrate 1 (mouse) that has been phosphorylated at Ser-307. UniProtKB:P35569, Ser-307, MOD:00046." [PMID:14998989, PMID:15314024, iPTMnet:P35569]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:14998989, PMID:15314024). Status=unreviewed.
synonym: "mIRS1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P35569, Ser-307, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P35569 ! insulin receptor substrate 1 (mouse)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:P35570
name: insulin receptor substrate 1 (rat)
def: "An insulin receptor substrate 1 that is encoded in the genome of rat." [OMA:P35570, PRO:DNx]
comment: Category=organism-gene.
synonym: "Irs1" RELATED Gene-based [UniProtKB:P35570]
synonym: "Irs-1" RELATED Gene-based [UniProtKB:P35570]
synonym: "rIRS1" EXACT PRO-short-label [PRO:DNx]
synonym: "IRS-1 (rat)" EXACT [UniProtKB:P35570]
synonym: "pp185 (rat)" EXACT [UniProtKB:P35570]
xref: UniProtKB:P35570
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000009107 ! insulin receptor substrate 1
relationship: has_gene_template RGD:2922 ! Irs1 (rat)