[Term] id: PR:000009241 name: eukaryotic-type lysine--tRNA ligase def: "A protein that is a translation product of the human KARS1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "KARS" RELATED Gene-based [] synonym: "KARS1" EXACT PRO-short-label [PRO:DNx] synonym: "LysRS" BROAD [PRO:DNx] synonym: "KIAA0070" RELATED Gene-based [] synonym: "lysyl-tRNA synthetase" EXACT [] synonym: "eukaryotic lysyl-tRNA synthetase" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:Q15046-2 name: lysine--tRNA ligase isoform Mitochondrial (human) def: "A lysine--tRNA ligase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15046-2." [PRO:DNx, UniProtKB:Q15046] comment: Category=organism-sequence. synonym: "hKARS1/iso:Mitochondrial" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q15046-2 is_a: PR:Q15046 ! lysine--tRNA ligase (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q15046-1 name: lysine--tRNA ligase isoform Cytoplasmic (human) def: "A lysine--tRNA ligase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q15046-1." [PRO:DNx, UniProtKB:Q15046] comment: Category=organism-sequence. synonym: "hKARS1/iso:Cytoplasmic" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q15046-1 is_a: PR:Q15046 ! lysine--tRNA ligase (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000027320 name: lysine--tRNA ligase, initiator methionine removed form (human) def: "A eukaryotic-type lysine--tRNA ligase, initiator methionine removed form in human. Example: UniProtKB:Q15046-1, 2-597." [PRO:DNx] comment: Category=organism-modification. synonym: "PRO_0000152765" NARROW PRO-proteoform-ftid [PRO:DNx] synonym: "hKARS/InitMet-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q15046-1, 2-597" NARROW PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-379568 "PR:000027320 located_in GO:0005829" xref: Reactome:R-HSA-379617 "PR:000027320 located_in GO:0005759" intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000020366 ! eukaryotic-type lysine--tRNA ligase, initiator methionine removed form [Term] id: PR:Q15046 name: lysine--tRNA ligase (human) def: "A eukaryotic-type lysine--tRNA ligase that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q15046] comment: Category=organism-gene. synonym: "KARS" RELATED Gene-based [UniProtKB:Q15046] synonym: "KARS1" RELATED Gene-based [UniProtKB:Q15046] synonym: "hKARS1" EXACT PRO-short-label [PRO:DNx] synonym: "KIAA0070" RELATED Gene-based [UniProtKB:Q15046] synonym: "LysRS (human)" EXACT [UniProtKB:Q15046] synonym: "lysyl-tRNA synthetase (human)" EXACT [UniProtKB:Q15046] xref: UniProtKB:Q15046 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000009241 ! eukaryotic-type lysine--tRNA ligase relationship: has_gene_template HGNC:6215 ! KARS1 (human) [Term] id: PR:000045936 name: lysine--tRNA ligase phosphorylated 1 (human) def: "A lysine--tRNA ligase (human) that has been phosphorylated on the residue at the position equivalent to Ser-207 of the amino acid sequence represented by UniProtKB:Q15046-1. Example: UniProtKB:Q15046-1, Ser-207, MOD:00046." [PMID:19524539, iPTMnet:Q15046] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:19524539). Status=unreviewed. synonym: "hKARS/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q15046-1, Ser-207, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:Q15046 ! lysine--tRNA ligase (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens