[Term] id: PR:Q13164-1 name: mitogen-activated protein kinase 7 isoform 1 (human) def: "A mitogen-activated protein kinase 7 isoform 1 that is encoded in the genome of human." [PMID:20832753, PRO:CNA] comment: Category=organism-sequence. Requested by=PubChem. synonym: "hMAPK7/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q13164-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000026477 ! mitogen-activated protein kinase 7 isoform 1 [Term] id: PR:Q13164-2 name: mitogen-activated protein kinase 7 isoform h2 (human) def: "A mitogen-activated protein kinase 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13164-2." [PRO:DNx, UniProtKB:Q13164] comment: Category=organism-sequence. synonym: "hMAPK7/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q13164-2 is_a: PR:Q13164 ! mitogen-activated protein kinase 7 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q13164-3 name: mitogen-activated protein kinase 7 isoform h3 (human) def: "A mitogen-activated protein kinase 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13164-3." [PRO:DNx, UniProtKB:Q13164] comment: Category=organism-sequence. synonym: "hMAPK7/iso:h3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q13164-3 is_a: PR:Q13164 ! mitogen-activated protein kinase 7 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q13164-4 name: mitogen-activated protein kinase 7 isoform h4 (human) def: "A mitogen-activated protein kinase 7 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13164-4." [PRO:DNx, UniProtKB:Q13164] comment: Category=organism-sequence. synonym: "hMAPK7/iso:h4" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q13164-4 is_a: PR:Q13164 ! mitogen-activated protein kinase 7 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q13164 name: mitogen-activated protein kinase 7 (human) def: "A mitogen-activated protein kinase 7 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q13164] comment: Category=organism-gene. synonym: "BMK1" RELATED Gene-based [UniProtKB:Q13164] synonym: "ERK5" RELATED Gene-based [UniProtKB:Q13164] synonym: "MAPK7" RELATED Gene-based [UniProtKB:Q13164] synonym: "PRKM7" RELATED Gene-based [UniProtKB:Q13164] synonym: "hMAPK7" EXACT PRO-short-label [PRO:DNx] synonym: "BMK-1 (human)" EXACT [UniProtKB:Q13164] synonym: "ERK-5 (human)" EXACT [UniProtKB:Q13164] synonym: "MAPK 7 (human)" EXACT [UniProtKB:Q13164] synonym: "MAP kinase 7 (human)" EXACT [UniProtKB:Q13164] synonym: "Big MAP kinase 1 (human)" EXACT [UniProtKB:Q13164] synonym: "extracellular signal-regulated kinase 5 (human)" EXACT [UniProtKB:Q13164] xref: DTO:03100319 xref: UniProtKB:Q13164 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000010159 ! mitogen-activated protein kinase 7 relationship: has_gene_template HGNC:6880 ! MAPK7 (human) [Term] id: PR:000010159 name: mitogen-activated protein kinase 7 def: "A protein that is a translation product of the human MAPK7 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "BMK1" RELATED Gene-based [] synonym: "ERK5" RELATED Gene-based [] synonym: "BMK-1" EXACT [] synonym: "ERK-5" EXACT [] synonym: "MAPK7" EXACT PRO-short-label [PRO:DNx] synonym: "PRKM7" RELATED Gene-based [] synonym: "MAPK 7" EXACT [] synonym: "MAP kinase 7" EXACT [] synonym: "Big MAP kinase 1" EXACT [] synonym: "extracellular signal-regulated kinase 5" EXACT [] xref: IUPHARobj:2093 is_a: PR:000000001 ! protein [Term] id: PR:000026481 name: mitogen-activated protein kinase 7 isoform 1 phosphorylated 1 (human) def: "A mitogen-activated protein kinase 7 isoform 1 phosphorylated 1 in human. UniProtKB:Q13164-1, Thr-28/Thr-219/Thr-733, MOD:00047|Tyr-221, MOD:00048|Ser-421/Ser-433/Ser-496/Ser-731, MOD:00046." [PMID:12628002, PMID:20832753, PRO:CNA] comment: Category=organism-modification. Kinase=("BMK1"; PR:000048327; Thr-28/Ser-421/Ser-433/Ser-496/Ser-731/Thr-733). synonym: "BMK1 active form" RELATED [] synonym: "hMAPK7/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q13164-1, Thr-28/Thr-219/Thr-733, MOD:00047|Ser-421/Ser-433/Ser-496/Ser-731, MOD:00046|Tyr-221, MOD:00048" EXACT PRO-proteoform-std [PRO:DAN] is_a: PR:000026479 ! mitogen-activated protein kinase 7 isoform 1 phosphorylated 1 relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000048327 name: mitogen-activated protein kinase 7, initiator methionine removed phosphorylated 2 (human) def: "A mitogen-activated protein kinase 7 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphothreonine at position 219, and phosphotyrosine at position 221 of the amino acid sequence represented by UniProtKB:Q13164. UniProtKB:Q13164, 2-816, Thr-219, MOD:00047|Tyr-221, MOD:00048." [PMID:12628002, PRO:DAN, Reactome:R-HSA-198721, Reactome:R-HSA-198738] comment: Category=organism-modification. Note: The modified site indicated here (Thr-219/Tyr-221) is referred to as Thr-218/Tyr-220 in the literature using the rat sequence. [PRO:DAN, PMID:11544482] synonym: "hMAPK7/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000186260, Thr-219, MOD:00047|Tyr-221, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DAN] synonym: "UniProtKB:Q13164, 2-816, Thr-219, MOD:00047|Tyr-221, MOD:00048" EXACT PRO-proteoform-std [PRO:DAN] xref: Reactome:R-HSA-198721 "PR:000048327 located_in GO:0005829" xref: Reactome:R-HSA-198738 "PR:000048327 located_in GO:0005654" is_a: PR:Q13164 ! mitogen-activated protein kinase 7 (human) relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000048326 name: mitogen-activated protein kinase 7, initiator methionine removed form (human) def: "A mitogen-activated protein kinase 7 (human) that has had the initiator methionine removed. UniProtKB:Q13164, 2-816." [PRO:DNx, Reactome:R-HSA-198754, Reactome:R-HSA-199961] comment: Category=organism-modification. synonym: "PRO_0000186260" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hMAPK7/InitMet-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q13164, 2-816" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-198754 "PR:000048326 located_in GO:0005829" xref: Reactome:R-HSA-199961 "PR:000048326 located_in GO:0005654" intersection_of: lacks_part PR:000021937 ! initiator methionine intersection_of: PR:Q13164 ! mitogen-activated protein kinase 7 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens