[Term]
id: PR:000010267
name: E3 ubiquitin-protein ligase Mdm2
def: "A protein that is a translation product of the human MDM2 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "MDM2" EXACT PRO-short-label [PRO:DNx]
synonym: "hdm2" EXACT []
synonym: "oncoprotein Mdm2" EXACT []
synonym: "double minute 2 protein" EXACT []
synonym: "p53-binding protein Mdm2" EXACT []
synonym: "RING-type E3 ubiquitin transferase Mdm2" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:Q00987
name: E3 ubiquitin-protein ligase Mdm2 (human)
def: "An E3 ubiquitin-protein ligase Mdm2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q00987]
comment: Category=organism-gene.
synonym: "MDM2" RELATED Gene-based [UniProtKB:Q00987]
synonym: "hMDM2" EXACT PRO-short-label [PRO:DNx]
synonym: "Hdm2 (human)" EXACT [UniProtKB:Q00987]
synonym: "oncoprotein Mdm2 (human)" EXACT [UniProtKB:Q00987]
synonym: "double minute 2 protein (human)" EXACT [UniProtKB:Q00987]
synonym: "p53-binding protein Mdm2 (human)" EXACT [UniProtKB:Q00987]
synonym: "RING-type E3 ubiquitin transferase Mdm2 (human)" EXACT [UniProtKB:Q00987]
xref: Reactome:R-HSA-69486 "PR:Q00987 located_in GO:0005654"
xref: Reactome:R-HSA-198644 "PR:Q00987 located_in GO:0005829"
xref: Reactome:R-HSA-416843 "PR:Q00987 located_in GO:0005886"
xref: Reactome:R-HSA-416849 "PR:Q00987 located_in GO:0030666"
xref: UniProtKB:Q00987
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000010267 ! E3 ubiquitin-protein ligase Mdm2
relationship: has_gene_template HGNC:6973 ! MDM2 (human)

[Term]
id: PR:Q00987-1
name: E3 ubiquitin-protein ligase Mdm2 isoform Mdm2 (human)
def: "An E3 ubiquitin-protein ligase Mdm2 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hMDM2/iso:Mdm2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q00987-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000026001 ! E3 ubiquitin-protein ligase Mdm2 isoform 1

[Term]
id: PR:Q00987-3
name: E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-A1 (human)
def: "An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-3." [PRO:DNx, UniProtKB:Q00987]
comment: Category=organism-sequence.
synonym: "hMDM2/iso:hMdm2-A1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q00987-3
is_a: PR:Q00987 ! E3 ubiquitin-protein ligase Mdm2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q00987-2
name: E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-A (human)
def: "An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-2." [PRO:DNx, UniProtKB:Q00987]
comment: Category=organism-sequence.
synonym: "hMDM2/iso:hMdm2-A" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q00987-2
is_a: PR:Q00987 ! E3 ubiquitin-protein ligase Mdm2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q00987-5
name: E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-C (human)
def: "An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-5." [PRO:DNx, UniProtKB:Q00987]
comment: Category=organism-sequence.
synonym: "hMDM2/iso:hMdm2-C" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q00987-5
is_a: PR:Q00987 ! E3 ubiquitin-protein ligase Mdm2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q00987-4
name: E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-B (human)
def: "An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-4." [PRO:DNx, UniProtKB:Q00987]
comment: Category=organism-sequence.
synonym: "hMDM2/iso:hMdm2-B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q00987-4
is_a: PR:Q00987 ! E3 ubiquitin-protein ligase Mdm2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q00987-7
name: E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-E (human)
def: "An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-7." [PRO:DNx, UniProtKB:Q00987]
comment: Category=organism-sequence.
synonym: "hMDM2/iso:hMdm2-E" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q00987-7
is_a: PR:Q00987 ! E3 ubiquitin-protein ligase Mdm2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q00987-6
name: E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-D (human)
def: "An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-6." [PRO:DNx, UniProtKB:Q00987]
comment: Category=organism-sequence.
synonym: "hMDM2/iso:hMdm2-D" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q00987-6
is_a: PR:Q00987 ! E3 ubiquitin-protein ligase Mdm2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q00987-9
name: E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-F (human)
def: "An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-9." [PRO:DNx, UniProtKB:Q00987]
comment: Category=organism-sequence.
synonym: "hMDM2/iso:hMdm2-F" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q00987-9
is_a: PR:Q00987 ! E3 ubiquitin-protein ligase Mdm2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048360
name: E3 ubiquitin-protein ligase Mdm2 ubiquitinated form (human)
def: "An E3 ubiquitin-protein ligase Mdm2 (human) that includes at least one ubiquitinated lysine. UniProtKB:Q00987, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782472]
comment: Category=organism-modification.
synonym: "hMDM2/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q00987, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6782472 "PR:000048360 located_in GO:0005654"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:Q00987 ! E3 ubiquitin-protein ligase Mdm2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P23804
name: E3 ubiquitin-protein ligase Mdm2 (mouse)
def: "An E3 ubiquitin-protein ligase Mdm2 that is encoded in the genome of mouse." [OMA:P23804, PRO:DNx]
comment: Category=organism-gene.
synonym: "Mdm2" RELATED Gene-based [UniProtKB:P23804]
synonym: "mMDM2" EXACT PRO-short-label [PRO:DNx]
synonym: "oncoprotein Mdm2 (mouse)" EXACT [UniProtKB:P23804]
synonym: "double minute 2 protein (mouse)" EXACT [UniProtKB:P23804]
synonym: "p53-binding protein Mdm2 (mouse)" EXACT [UniProtKB:P23804]
synonym: "RING-type E3 ubiquitin transferase Mdm2 (mouse)" EXACT [UniProtKB:P23804]
xref: UniProtKB:P23804
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000010267 ! E3 ubiquitin-protein ligase Mdm2
relationship: has_gene_template MGI:96952 ! Mdm2 (mouse)

[Term]
id: PR:Q00987-8
name: E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-alpha (human)
def: "An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-8." [PRO:DNx, UniProtKB:Q00987]
comment: Category=organism-sequence.
synonym: "hMDM2/iso:hMdm2-alpha" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q00987-8
is_a: PR:Q00987 ! E3 ubiquitin-protein ligase Mdm2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O42354
name: E3 ubiquitin-protein ligase Mdm2 (zebrafish)
def: "An E3 ubiquitin-protein ligase Mdm2 that is encoded in the genome of zebrafish." [PANTHER:PTHR10360:SF9, PRO:DNx]
comment: Category=organism-gene.
synonym: "mdm2" RELATED Gene-based [UniProtKB:O42354]
synonym: "z-MDM2" EXACT PRO-short-label [PRO:DNx]
synonym: "double minute 2 protein (zebrafish)" EXACT [UniProtKB:O42354]
synonym: "p53-binding protein Mdm2 (zebrafish)" EXACT [UniProtKB:O42354]
synonym: "RING-type E3 ubiquitin transferase Mdm2 (zebrafish)" EXACT [UniProtKB:O42354]
xref: UniProtKB:O42354
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000010267 ! E3 ubiquitin-protein ligase Mdm2
relationship: has_gene_template ZFIN:ZDB-GENE-990415-153 ! mdm2 (zebrafish)

[Term]
id: PR:P23804-2
name: E3 ubiquitin-protein ligase Mdm2 isoform 2 (mouse)
def: "An E3 ubiquitin-protein ligase Mdm2 isoform 2 that is encoded in the genome of mouse." [PMID:10075719, PRO:HJD]
comment: Category=organism-sequence.
synonym: "mMDM2/iso:2" EXACT PRO-short-label [PRO:DNx]
synonym: "Mdm2-p76 (mouse)" EXACT []
xref: UniProtKB:P23804-2
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000026003 ! E3 ubiquitin-protein ligase Mdm2 isoform 2

[Term]
id: PR:P23804-1
name: E3 ubiquitin-protein ligase Mdm2 isoform 1 (mouse)
def: "An E3 ubiquitin-protein ligase Mdm2 isoform 1 that is encoded in the genome of mouse." [PMID:2026149, PRO:HJD]
comment: Category=organism-sequence.
synonym: "mMDM2/iso:1" EXACT PRO-short-label [PRO:DNx]
synonym: "Mdm2-p90 (mouse)" EXACT []
xref: UniProtKB:P23804-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000026001 ! E3 ubiquitin-protein ligase Mdm2 isoform 1

[Term]
id: PR:000045866
name: E3 ubiquitin-protein ligase Mdm2 phosphorylated 1 (human)
def: "An E3 ubiquitin-protein ligase Mdm2 (human) that has been phosphorylated on the residue at the position equivalent to Tyr-394 of the amino acid sequence represented by UniProtKB:Q00987-1. Example: UniProtKB:Q00987-1, Tyr-394, MOD:00048." [PMID:12110584, iPTMnet:Q00987]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:12110584). Status=unreviewed.
synonym: "hMDM2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q00987-1, Tyr-394, MOD:00048" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:Q00987 ! E3 ubiquitin-protein ligase Mdm2 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000026001
name: E3 ubiquitin-protein ligase Mdm2 isoform 1
def: "An E3 ubiquitin-protein ligase Mdm2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23804-1 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "MDM2/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000010267 ! E3 ubiquitin-protein ligase Mdm2

[Term]
id: PR:000026003
name: E3 ubiquitin-protein ligase Mdm2 isoform 2
def: "An E3 ubiquitin-protein ligase Mdm2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23804-2 or a 1:1 ortholog thereof." [PRO:CNA]
comment: Category=sequence.
synonym: "MDM2/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000010267 ! E3 ubiquitin-protein ligase Mdm2

[Term]
id: PR:000048357
name: E3 ubiquitin-protein ligase Mdm2 phosphorylated 2 (human)
def: "An E3 ubiquitin-protein ligase Mdm2 (human) that has been post-translationally modified to include phosphoserine at positions 166 and 188 of the amino acid sequence represented by UniProtKB:Q00987. UniProtKB:Q00987, Ser-166/Ser-188, MOD:00046." [PRO:DNx, Reactome:R-HSA-198638, Reactome:R-HSA-6793669]
comment: Category=organism-modification.
synonym: "hMDM2/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q00987, Ser-166/Ser-188, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-198638 "PR:000048357 located_in GO:0005829"
xref: Reactome:R-HSA-6793669 "PR:000048357 located_in GO:0005654"
is_a: PR:Q00987 ! E3 ubiquitin-protein ligase Mdm2 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048358
name: E3 ubiquitin-protein ligase Mdm2 phosphorylated 3 (human)
def: "An E3 ubiquitin-protein ligase Mdm2 (human) that has been post-translationally modified to include phosphoserine at positions 166 and 188, and phosphothreonine at position 218 of the amino acid sequence represented by UniProtKB:Q00987. UniProtKB:Q00987, Ser-166/Ser-188, MOD:00046|Thr-218, MOD:00047." [PRO:DNx, Reactome:R-HSA-6792862]
comment: Category=organism-modification.
synonym: "hMDM2/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q00987, Ser-166/Ser-188, MOD:00046|Thr-218, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6792862 "PR:000048358 located_in GO:0005654"
is_a: PR:Q00987 ! E3 ubiquitin-protein ligase Mdm2 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000048359
name: E3 ubiquitin-protein ligase Mdm2 phosphorylated 4 (human)
def: "An E3 ubiquitin-protein ligase Mdm2 (human) that has been post-translationally modified to include phosphoserine at positions 166, 188, 386, 395 and 407, and phosphothreonine at position 419 of the amino acid sequence represented by UniProtKB:Q00987. UniProtKB:Q00987, Ser-166/Ser-188/Ser-386/Ser-395/Ser-407, MOD:00046|Thr-419, MOD:00047." [PRO:DNx, Reactome:R-HSA-6804954]
comment: Category=organism-modification.
synonym: "hMDM2/Phos:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q00987, Ser-166/Ser-188/Ser-386/Ser-395/Ser-407, MOD:00046|Thr-419, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6804954 "PR:000048359 located_in GO:0005654"
is_a: PR:Q00987 ! E3 ubiquitin-protein ligase Mdm2 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000046153
name: E3 ubiquitin-protein ligase Mdm2 phosphorylated 1 (mouse)
def: "An E3 ubiquitin-protein ligase Mdm2 (mouse) that has been phosphorylated on the residue at the position equivalent to Thr-216 of the amino acid sequence represented by UniProtKB:P23804-1. Example: UniProtKB:P23804-1, Thr-216, MOD:00047." [PMID:11359766, iPTMnet:P23804]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:11359766). Status=unreviewed.
synonym: "mMDM2/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P23804-1, Thr-216, MOD:00047" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:P23804 ! E3 ubiquitin-protein ligase Mdm2 (mouse)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:Q00987-11
name: E3 ubiquitin-protein ligase Mdm2 isoform h11 (human)
def: "An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-11." [PRO:DNx, UniProtKB:Q00987]
comment: Category=organism-sequence.
synonym: "hMDM2/iso:h11" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q00987-11
is_a: PR:Q00987 ! E3 ubiquitin-protein ligase Mdm2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q00987-10
name: E3 ubiquitin-protein ligase Mdm2 isoform hMdm2-G (human)
def: "An E3 ubiquitin-protein ligase Mdm2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q00987-10." [PRO:DNx, UniProtKB:Q00987]
comment: Category=organism-sequence.
synonym: "hMDM2/iso:hMdm2-G" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q00987-10
is_a: PR:Q00987 ! E3 ubiquitin-protein ligase Mdm2 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens