[Term] id: PR:O75469-6 name: nuclear receptor subfamily 1 group I member 2 isoform h2C (human) def: "A nuclear receptor subfamily 1 group I member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75469-6." [PRO:DNx, UniProtKB:O75469] comment: Category=organism-sequence. synonym: "hNR1I2/iso:h2C" EXACT PRO-short-label [PRO:DNx] synonym: "nuclear receptor subfamily 1 group I member 2 isoform PRR2-C (human)" EXACT [UniProtKB:O75469] xref: Reactome:R-HSA-3196160 "PR:O75469-6 located_in GO:0005654" xref: UniProtKB:O75469-6 is_a: PR:O75469 ! nuclear receptor subfamily 1 group I member 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O75469-7 name: nuclear receptor subfamily 1 group I member 2 isoform h3 (human) def: "A nuclear receptor subfamily 1 group I member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75469-7." [PRO:DNx, UniProtKB:O75469] comment: Category=organism-sequence. synonym: "hNR1I2/iso:h3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:O75469-7 is_a: PR:O75469 ! nuclear receptor subfamily 1 group I member 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O75469-4 name: nuclear receptor subfamily 1 group I member 2 isoform h2A (human) def: "A nuclear receptor subfamily 1 group I member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75469-4." [PRO:DNx, UniProtKB:O75469] comment: Category=organism-sequence. synonym: "hNR1I2/iso:h2A" EXACT PRO-short-label [PRO:DNx] synonym: "nuclear receptor subfamily 1 group I member 2 isoform 2 (human)" EXACT [UniProtKB:O75469] synonym: "nuclear receptor subfamily 1 group I member 2 isoform PRR2-A (human)" EXACT [UniProtKB:O75469] xref: Reactome:R-HSA-3196184 "PR:O75469-4 located_in GO:0005654" xref: UniProtKB:O75469-4 is_a: PR:O75469 ! nuclear receptor subfamily 1 group I member 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O75469-5 name: nuclear receptor subfamily 1 group I member 2 isoform h2B (human) def: "A nuclear receptor subfamily 1 group I member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75469-5." [PRO:DNx, UniProtKB:O75469] comment: Category=organism-sequence. synonym: "hNR1I2/iso:h2B" EXACT PRO-short-label [PRO:DNx] synonym: "nuclear receptor subfamily 1 group I member 2 isoform PRR2-B (human)" EXACT [UniProtKB:O75469] xref: Reactome:R-HSA-3196166 "PR:O75469-5 located_in GO:0005654" xref: UniProtKB:O75469-5 is_a: PR:O75469 ! nuclear receptor subfamily 1 group I member 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O75469-2 name: nuclear receptor subfamily 1 group I member 2 isoform h1B (human) def: "A nuclear receptor subfamily 1 group I member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75469-2." [PRO:DNx, UniProtKB:O75469] comment: Category=organism-sequence. synonym: "hNR1I2/iso:h1B" EXACT PRO-short-label [PRO:DNx] synonym: "nuclear receptor subfamily 1 group I member 2 isoform PRR1-B (human)" EXACT [UniProtKB:O75469] xref: Reactome:R-HSA-3196181 "PR:O75469-2 located_in GO:0005654" xref: UniProtKB:O75469-2 is_a: PR:O75469 ! nuclear receptor subfamily 1 group I member 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O75469-3 name: nuclear receptor subfamily 1 group I member 2 isoform h1C (human) def: "A nuclear receptor subfamily 1 group I member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75469-3." [PRO:DNx, UniProtKB:O75469] comment: Category=organism-sequence. synonym: "hNR1I2/iso:h1C" EXACT PRO-short-label [PRO:DNx] synonym: "nuclear receptor subfamily 1 group I member 2 isoform PRR1-C (human)" EXACT [UniProtKB:O75469] xref: UniProtKB:O75469-3 is_a: PR:O75469 ! nuclear receptor subfamily 1 group I member 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O75469-1 name: nuclear receptor subfamily 1 group I member 2 isoform h1A (human) def: "A nuclear receptor subfamily 1 group I member 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O75469-1." [PRO:DNx, UniProtKB:O75469] comment: Category=organism-sequence. synonym: "hNR1I2/iso:h1A" EXACT PRO-short-label [PRO:DNx] synonym: "nuclear receptor subfamily 1 group I member 2 isoform 1 (human)" EXACT [UniProtKB:O75469] synonym: "nuclear receptor subfamily 1 group I member 2 isoform PRR1-A (human)" EXACT [UniProtKB:O75469] xref: Reactome:R-HSA-3008636 "PR:O75469-1 located_in GO:0005654" xref: UniProtKB:O75469-1 is_a: PR:O75469 ! nuclear receptor subfamily 1 group I member 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O75469 name: nuclear receptor subfamily 1 group I member 2 (human) def: "A nuclear receptor subfamily 1 group I member 2 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O75469] comment: Category=organism-gene. synonym: "PXR" RELATED Gene-based [UniProtKB:O75469] synonym: "NR1I2" RELATED Gene-based [UniProtKB:O75469] synonym: "hNR1I2" EXACT PRO-short-label [PRO:DNx] synonym: "SXR (human)" EXACT [UniProtKB:O75469] synonym: "pregnane X receptor (human)" EXACT [UniProtKB:O75469] synonym: "orphan nuclear receptor PXR (human)" EXACT [UniProtKB:O75469] synonym: "orphan nuclear receptor PAR1 (human)" EXACT [UniProtKB:O75469] synonym: "steroid and xenobiotic receptor (human)" EXACT [UniProtKB:O75469] xref: Reactome:R-HSA-3196156 "PR:O75469 located_in GO:0005654" xref: Reactome:R-HSA-3196164 "PR:O75469 located_in GO:0005654" xref: DTO:00117497 xref: UniProtKB:O75469 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000011397 ! nuclear receptor subfamily 1 group I member 2 relationship: has_gene_template HGNC:7968 ! NR1I2 (human) [Term] id: PR:000045606 name: nuclear receptor subfamily 1 group I member 2 phosphorylated 1 (human) def: "A nuclear receptor subfamily 1 group I member 2 (human) that has been phosphorylated on the residue at the position equivalent to Ser-350 of the amino acid sequence represented by UniProtKB:O75469-1. Example: UniProtKB:O75469-1, Ser-350, MOD:00046." [PMID:18784074, iPTMnet:O75469] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:18784074). Status=unreviewed. synonym: "hNR1I2/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:O75469-1, Ser-350, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:O75469 ! nuclear receptor subfamily 1 group I member 2 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000011397 name: nuclear receptor subfamily 1 group I member 2 def: "A protein that is a translation product of the human NR1I2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "PXR" RELATED Gene-based [] synonym: "SXR" EXACT [] synonym: "NR1I2" EXACT PRO-short-label [PRO:DNx] synonym: "pregnane X receptor" EXACT [] synonym: "orphan nuclear receptor PXR" EXACT [] synonym: "orphan nuclear receptor PAR1" EXACT [] synonym: "steroid and xenobiotic receptor" EXACT [] xref: IUPHARobj:606 is_a: PR:000000001 ! protein