[Term] id: PR:000011470 name: BDNF/NT-3 growth factors receptor def: "A TRK receptor that is a translation product of the human NTRK2 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "TRKB" RELATED Gene-based [] synonym: "NTRK2" EXACT PRO-short-label [PRO:DNx] synonym: "Trk-B" EXACT [] synonym: "GP145-TrkB" EXACT [] synonym: "GP145-TrkB/GP95-TrkB" EXACT [] synonym: "TrkB tyrosine kinase" EXACT [] synonym: "neurotrophic tyrosine kinase receptor type 2" EXACT [] xref: IUPHARobj:1818 is_a: PR:000021997 ! TRK receptor [Term] id: PR:000048646 name: BDNF/NT-3 growth factors receptor, signal peptide removed phosphorylated 1 (human) def: "A BDNF/NT-3 growth factors receptor (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 516, 702, 706, 706 and 817 of the amino acid sequence represented by UniProtKB:Q16620. UniProtKB:Q16620, 32-822, Tyr-516/Tyr-702/Tyr-706/Tyr-707/Tyr-817, MOD:00048." [PRO:DAN, Reactome:R-HSA-3008809] comment: Category=organism-modification. Note: The modified sites indicated here (Tyr-516/Tyr-701/Tyr-705/Tyr-706/Tyr-817) are referred to as Tyr-490/Tyr-670/Tyr-674/Tyr-675/Tyr-785 in the literature using the rat sequence. [PRO:DAN, PMID:8106527] synonym: "hNTRK2/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000016727, Tyr-516/Tyr-702/Tyr-706/Tyr-707/Tyr-817, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:Q16620, 32-822, Tyr-516/Tyr-702/Tyr-706/Tyr-707/Tyr-817, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-3008809 "PR:000048646 located_in GO:0000139" xref: Reactome:R-HSA-9026475 "PR:000048646 located_in GO:0005886" is_a: PR:Q16620 ! BDNF/NT-3 growth factors receptor (human) relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: lacks_part SO:0000418 ! signal_peptide [Term] id: PR:Q16620-1 name: BDNF/NT-3 growth factors receptor isoform TrkB (human) def: "A BDNF/NT-3 growth factors receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16620-1." [PRO:DNx, UniProtKB:Q16620] comment: Category=organism-sequence. synonym: "hNTRK2/iso:TrkB" EXACT PRO-short-label [PRO:DNx] synonym: "BDNF/NT-3 growth factors receptor isoform gp145-TrkB (human)" EXACT [UniProtKB:Q16620] xref: UniProtKB:Q16620-1 is_a: PR:Q16620 ! BDNF/NT-3 growth factors receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q16620-2 name: BDNF/NT-3 growth factors receptor isoform hTrkB-T1 (human) def: "A BDNF/NT-3 growth factors receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16620-2." [PRO:DNx, UniProtKB:Q16620] comment: Category=organism-sequence. synonym: "hNTRK2/iso:hTrkB-T1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q16620-2 is_a: PR:Q16620 ! BDNF/NT-3 growth factors receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000048645 name: BDNF/NT-3 growth factors receptor, signal peptide removed form (human) def: "A BDNF/NT-3 growth factors receptor (human) that has had the signal peptide removed. UniProtKB:Q16620, 32-822." [PRO:DNx, Reactome:R-HSA-3008801] comment: Category=organism-modification. synonym: "PRO_0000016727" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hNTRK2/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q16620, 32-822" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-3008801 "PR:000048645 located_in GO:0000139" xref: Reactome:R-HSA-6798236 "PR:000048645 located_in GO:0005886" intersection_of: PR:Q16620 ! BDNF/NT-3 growth factors receptor (human) intersection_of: lacks_part SO:0000418 ! signal_peptide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q16620-4 name: BDNF/NT-3 growth factors receptor isoform h4 (human) def: "A BDNF/NT-3 growth factors receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16620-4." [PRO:DNx, UniProtKB:Q16620] comment: Category=organism-sequence. synonym: "hNTRK2/iso:h4" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q16620-4 is_a: PR:Q16620 ! BDNF/NT-3 growth factors receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q16620 name: BDNF/NT-3 growth factors receptor (human) def: "A BDNF/NT-3 growth factors receptor that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q16620] comment: Category=organism-gene. synonym: "TRKB" RELATED Gene-based [UniProtKB:Q16620] synonym: "NTRK2" RELATED Gene-based [UniProtKB:Q16620] synonym: "hNTRK2" EXACT PRO-short-label [PRO:DNx] synonym: "Trk-B (human)" EXACT [UniProtKB:Q16620] synonym: "GP145-TrkB (human)" EXACT [UniProtKB:Q16620] synonym: "TrkB tyrosine kinase (human)" EXACT [UniProtKB:Q16620] synonym: "tropomyosin-related kinase B (human)" EXACT [UniProtKB:Q16620] synonym: "neurotrophic tyrosine kinase receptor type 2 (human)" EXACT [UniProtKB:Q16620] xref: DTO:03100372 xref: UniProtKB:Q16620 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000011470 ! BDNF/NT-3 growth factors receptor relationship: has_gene_template HGNC:8032 ! NTRK2 (human) [Term] id: PR:Q16620-6 name: BDNF/NT-3 growth factors receptor isoform TrkB-T-TK (human) def: "A BDNF/NT-3 growth factors receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16620-6." [PRO:DNx, UniProtKB:Q16620] comment: Category=organism-sequence. synonym: "hNTRK2/iso:TrkB-T-TK" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q16620-6 is_a: PR:Q16620 ! BDNF/NT-3 growth factors receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q16620-7 name: BDNF/NT-3 growth factors receptor isoform hTrkB-N-T1 (human) def: "A BDNF/NT-3 growth factors receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16620-7." [PRO:DNx, UniProtKB:Q16620] comment: Category=organism-sequence. synonym: "hNTRK2/iso:hTrkB-N-T1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q16620-7 is_a: PR:Q16620 ! BDNF/NT-3 growth factors receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q16620-3 name: BDNF/NT-3 growth factors receptor isoform TrkB-T-Shc (human) def: "A BDNF/NT-3 growth factors receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16620-3." [PRO:DNx, UniProtKB:Q16620] comment: Category=organism-sequence. synonym: "hNTRK2/iso:TrkB-T-Shc" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q16620-3 is_a: PR:Q16620 ! BDNF/NT-3 growth factors receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q16620-5 name: BDNF/NT-3 growth factors receptor isoform h5 (human) def: "A BDNF/NT-3 growth factors receptor (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q16620-5." [PRO:DNx, UniProtKB:Q16620] comment: Category=organism-sequence. synonym: "hNTRK2/iso:h5" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q16620-5 is_a: PR:Q16620 ! BDNF/NT-3 growth factors receptor (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens