[Term]
id: PR:000012331
name: pyruvate carboxylase, mitochondrial
def: "A protein that is a translation product of the human PC gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PC" EXACT PRO-short-label [PRO:DNx]
synonym: "PCB" EXACT []
synonym: "Pcx" RELATED Gene-based []
synonym: "pyruvic carboxylase" BROAD []
synonym: "pyruvic carboxylase, mitochondrial" EXACT []
xref: IUPHARobj:1262
is_a: PR:000000001 ! protein

[Term]
id: PR:P52873
name: pyruvate carboxylase, mitochondrial (rat)
def: "A pyruvate carboxylase, mitochondrial that is encoded in the genome of rat." [PANTHER:PTHR18866:SF10, PRO:DNx]
comment: Category=organism-gene.
synonym: "Pc" RELATED Gene-based [UniProtKB:P52873]
synonym: "rPC" EXACT PRO-short-label [PRO:DNx]
synonym: "PCB (rat)" EXACT [UniProtKB:P52873]
synonym: "pyruvic carboxylase (rat)" EXACT [UniProtKB:P52873]
xref: UniProtKB:P52873
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000012331 ! pyruvate carboxylase, mitochondrial
relationship: has_gene_template RGD:3262 ! Pc (rat)

[Term]
id: PR:Q9UUE1
name: pyruvate carboxylase (Schizosaccharomyces pombe 972h-)
def: "A pyruvate carboxylase, mitochondrial that is encoded in the genome of Schizosaccharomyces pombe 972h-." [PRO:DNx]
comment: Category=organism-gene.
synonym: "pyr1" RELATED Gene-based [UniProtKB:Q9UUE1]
synonym: "Spom972h-PC" EXACT PRO-short-label [PRO:DNx]
synonym: "SPBC17G9.11c" RELATED Gene-based [UniProtKB:Q9UUE1]
synonym: "PCB (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q9UUE1]
synonym: "pyruvic carboxylase (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q9UUE1]
xref: UniProtKB:Q9UUE1
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000012331 ! pyruvate carboxylase, mitochondrial
relationship: has_gene_template PomBase:SPBC17G9.11c ! pyr1 (Schizosaccharomyces pombe)

[Term]
id: PR:P11498-1
name: pyruvate carboxylase, mitochondrial isoform 1 (human)
def: "A pyruvate carboxylase, mitochondrial isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPC/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P11498-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000038848 ! pyruvate carboxylase, mitochondrial isoform 1

[Term]
id: PR:Q05920
name: pyruvate carboxylase, mitochondrial (mouse)
def: "A pyruvate carboxylase, mitochondrial that is encoded in the genome of mouse." [OMA:Q05920, PRO:DNx]
comment: Category=organism-gene.
synonym: "Pc" RELATED Gene-based [UniProtKB:Q05920]
synonym: "Pcx" RELATED Gene-based [UniProtKB:Q05920]
synonym: "mPC" EXACT PRO-short-label [PRO:DNx]
synonym: "PCB (mouse)" EXACT [UniProtKB:Q05920]
synonym: "pyruvic carboxylase (mouse)" EXACT [UniProtKB:Q05920]
xref: UniProtKB:Q05920
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000012331 ! pyruvate carboxylase, mitochondrial
relationship: has_gene_template MGI:97520 ! Pcx (mouse)

[Term]
id: PR:P11498-2
name: pyruvate carboxylase, mitochondrial isoform h2 (human)
def: "A pyruvate carboxylase, mitochondrial (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11498-2." [PRO:DNx, UniProtKB:P11498]
comment: Category=organism-sequence.
synonym: "hPC/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P11498-2
is_a: PR:P11498 ! pyruvate carboxylase, mitochondrial (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000038848
name: pyruvate carboxylase, mitochondrial isoform 1
def: "A pyruvate carboxylase, mitochondrial that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P11498-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "PC/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000012331 ! pyruvate carboxylase, mitochondrial

[Term]
id: PR:P11498
name: pyruvate carboxylase, mitochondrial (human)
def: "A pyruvate carboxylase, mitochondrial that is encoded in the genome of human." [PRO:DNx, UniProtKB:P11498]
comment: Category=organism-gene.
synonym: "PC" RELATED Gene-based [UniProtKB:P11498]
synonym: "hPC" EXACT PRO-short-label [PRO:DNx]
synonym: "PCB (human)" EXACT [UniProtKB:P11498]
synonym: "pyruvic carboxylase (human)" EXACT [UniProtKB:P11498]
xref: UniProtKB:P11498
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012331 ! pyruvate carboxylase, mitochondrial
relationship: has_gene_template HGNC:8636 ! PC (human)

[Term]
id: PR:P52873-1
name: pyruvate carboxylase, mitochondrial isoform 1 (rat)
def: "A pyruvate carboxylase, mitochondrial isoform 1 that is encoded in the genome of rat." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "rPC/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P52873-1
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000038848 ! pyruvate carboxylase, mitochondrial isoform 1

[Term]
id: PR:O17732
name: pyruvate carboxylase 1 (worm)
def: "A pyruvate carboxylase, mitochondrial that is encoded in the genome of worm." [PRO:DNx]
comment: Category=organism-gene.
synonym: "pyc-1" RELATED Gene-based [UniProtKB:O17732]
synonym: "D2023.2" RELATED Gene-based [UniProtKB:O17732]
synonym: "PC (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "PCB 1 (worm)" EXACT [UniProtKB:O17732]
synonym: "pyruvic carboxylase 1 (worm)" EXACT [UniProtKB:O17732]
xref: UniProtKB:O17732
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000012331 ! pyruvate carboxylase, mitochondrial
relationship: has_gene_template WormBase:WBGene00004258 ! pyc-1 (worm)

[Term]
id: PR:000048700
name: pyruvate carboxylase, mitochondrial, transit peptide removed biotinylated 1 (human)
def: "A pyruvate carboxylase, mitochondrial (human) that has had the transit peptide removed and has been post-translationally modified to include biotinylated lysine at position 1144 of the amino acid sequence represented by UniProtKB:P11498. UniProtKB:P11498, 21-1178, Lys-1144, MOD:00126." [PRO:DNx, Reactome:R-HSA-2993804, Reactome:R-HSA-3323170]
comment: Category=organism-modification.
synonym: "hPC/TransPep-/Btn:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000002840, Lys-1144, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P11498, 21-1178, Lys-1144, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3323170 "PR:000048700 located_in GO:0005829"
xref: Reactome:R-HSA-2993804 "PR:000048700 located_in GO:0005759"
is_a: PR:P11498 ! pyruvate carboxylase, mitochondrial (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000725 ! transit_peptide

[Term]
id: PR:000048699
name: pyruvate carboxylase, mitochondrial, transit peptide removed form (human)
def: "A pyruvate carboxylase, mitochondrial (human) that has had the transit peptide removed. UniProtKB:P11498, 21-1178." [PRO:DNx, Reactome:R-HSA-3323119, Reactome:R-HSA-70498]
comment: Category=organism-modification.
synonym: "hPC/TransPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000002840" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:P11498, 21-1178" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-70498 "PR:000048699 located_in GO:0005759"
xref: Reactome:R-HSA-3323119 "PR:000048699 located_in GO:0005829"
intersection_of: PR:P11498 ! pyruvate carboxylase, mitochondrial (human)
intersection_of: lacks_part SO:0000725 ! transit_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens