[Term]
id: PR:P59996
name: proprotein convertase subtilisin/kexin type 9 (rat)
def: "A proprotein convertase subtilisin/kexin type 9 that is encoded in the genome of rat." [OMA:P59996, PANTHER:PTHR10795:SF25, PRO:DNx]
comment: Category=organism-gene.
synonym: "Narc1" RELATED Gene-based [UniProtKB:P59996]
synonym: "Pcsk9" RELATED Gene-based [UniProtKB:P59996]
synonym: "rPCSK9" EXACT PRO-short-label [PRO:DNx]
synonym: "PC9 (rat)" EXACT [UniProtKB:P59996]
synonym: "NARC-1 (rat)" EXACT [UniProtKB:P59996]
synonym: "proprotein convertase 9 (rat)" EXACT [UniProtKB:P59996]
synonym: "subtilisin/kexin-like protease PC9 (rat)" EXACT [UniProtKB:P59996]
synonym: "neural apoptosis-regulated convertase 1 (rat)" EXACT [UniProtKB:P59996]
xref: UniProtKB:P59996
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000012440 ! proprotein convertase subtilisin/kexin type 9
relationship: has_gene_template RGD:728909 ! Pcsk9 (rat)

[Term]
id: PR:000012440
name: proprotein convertase subtilisin/kexin type 9
def: "A protein that is a translation product of the human PCSK9 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PC9" EXACT []
synonym: "NARC1" RELATED Gene-based []
synonym: "PCSK9" EXACT PRO-short-label [PRO:DNx]
synonym: "NARC-1" EXACT []
synonym: "PSEC0052" RELATED Gene-based []
synonym: "proprotein convertase 9" EXACT []
synonym: "subtilisin/kexin-like protease PC9" EXACT []
synonym: "neural apoptosis-regulated convertase 1" EXACT []
xref: IUPHARobj:2388
is_a: PR:000000001 ! protein

[Term]
id: PR:Q8NBP7-1
name: proprotein convertase subtilisin/kexin type 9 isoform h1 (human)
def: "A proprotein convertase subtilisin/kexin type 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NBP7-1." [PRO:DNx, UniProtKB:Q8NBP7]
comment: Category=organism-sequence.
synonym: "hPCSK9/iso:h1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8NBP7-1
is_a: PR:Q8NBP7 ! proprotein convertase subtilisin/kexin type 9 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:Q8NBP7-2
name: proprotein convertase subtilisin/kexin type 9 isoform h2 (human)
def: "A proprotein convertase subtilisin/kexin type 9 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8NBP7-2." [PRO:DNx, UniProtKB:Q8NBP7]
comment: Category=organism-sequence.
synonym: "hPCSK9/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q8NBP7-2
is_a: PR:Q8NBP7 ! proprotein convertase subtilisin/kexin type 9 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000020891
name: proprotein convertase subtilisin/kexin type 9, signal peptide removed form
def: "A proprotein convertase subtilisin/kexin type 9 that has had the signal peptide removed." [PRO:DNx]
comment: Category=modification.
synonym: "PCSK9/SigPep-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000012440 ! proprotein convertase subtilisin/kexin type 9
intersection_of: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:Q8NBP7
name: proprotein convertase subtilisin/kexin type 9 (human)
def: "A proprotein convertase subtilisin/kexin type 9 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8NBP7]
comment: Category=organism-gene.
synonym: "NARC1" RELATED Gene-based [UniProtKB:Q8NBP7]
synonym: "PCSK9" RELATED Gene-based [UniProtKB:Q8NBP7]
synonym: "hPCSK9" EXACT PRO-short-label [PRO:DNx]
synonym: "PSEC0052" RELATED Gene-based [UniProtKB:Q8NBP7]
synonym: "PC9 (human)" EXACT [UniProtKB:Q8NBP7]
synonym: "NARC-1 (human)" EXACT [UniProtKB:Q8NBP7]
synonym: "proprotein convertase 9 (human)" EXACT [UniProtKB:Q8NBP7]
synonym: "subtilisin/kexin-like protease PC9 (human)" EXACT [UniProtKB:Q8NBP7]
synonym: "neural apoptosis-regulated convertase 1 (human)" EXACT [UniProtKB:Q8NBP7]
xref: UniProtKB:Q8NBP7
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012440 ! proprotein convertase subtilisin/kexin type 9
relationship: has_gene_template HGNC:20001 ! PCSK9 (human)

[Term]
id: PR:Q80W65
name: proprotein convertase subtilisin/kexin type 9 (mouse)
def: "A proprotein convertase subtilisin/kexin type 9 that is encoded in the genome of mouse." [OMA:Q80W65, PRO:DNx]
comment: Category=organism-gene.
synonym: "Narc1" RELATED Gene-based [UniProtKB:Q80W65]
synonym: "Pcsk9" RELATED Gene-based [UniProtKB:Q80W65]
synonym: "mPCSK9" EXACT PRO-short-label [PRO:DNx]
synonym: "PC9 (mouse)" EXACT [UniProtKB:Q80W65]
synonym: "NARC-1 (mouse)" EXACT [UniProtKB:Q80W65]
synonym: "proprotein convertase 9 (mouse)" EXACT [UniProtKB:Q80W65]
synonym: "subtilisin/kexin-like protease PC9 (mouse)" EXACT [UniProtKB:Q80W65]
synonym: "neural apoptosis-regulated convertase 1 (mouse)" EXACT [UniProtKB:Q80W65]
xref: UniProtKB:Q80W65
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000012440 ! proprotein convertase subtilisin/kexin type 9
relationship: has_gene_template MGI:2140260 ! Pcsk9 (mouse)

[Term]
id: PR:000020892
name: proprotein convertase subtilisin/kexin type 9 proteolytic cleavage product
def: "A proprotein convertase subtilisin/kexin type 9 that has been processed by proteolytic cleavage." [PRO:DNx]
comment: Category=modification.
synonym: "PCSK9/ClvPrd" EXACT PRO-short-label [PRO:DNx]
intersection_of: output_of GO:0016485 ! protein processing
intersection_of: PR:000012440 ! proprotein convertase subtilisin/kexin type 9