[Term]
id: PR:000045599
name: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A phosphorylated 1 (human)
def: "A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (human) that has been phosphorylated on the residue at the position equivalent to Ser-359 of the amino acid sequence represented by UniProtKB:O60658-1. Example: UniProtKB:O60658-1, Ser-359, MOD:00046." [PMID:22673573, iPTMnet:O60658]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:22673573). Status=unreviewed.
synonym: "hPDE8A/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O60658-1, Ser-359, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx]
is_a: PR:O60658 ! high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000012486
name: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
def: "A protein that is a translation product of the human PDE8A gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "Pde8" RELATED Gene-based []
synonym: "PDE8A" EXACT PRO-short-label [PRO:DNx]
xref: IUPHARobj:1307
is_a: PR:000000001 ! protein

[Term]
id: PR:O60658
name: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (human)
def: "A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A that is encoded in the genome of human." [PRO:DNx, UniProtKB:O60658]
comment: Category=organism-gene.
synonym: "PDE8A" RELATED Gene-based [UniProtKB:O60658]
synonym: "hPDE8A" EXACT PRO-short-label [PRO:DNx]
xref: Reactome:R-HSA-418528 "PR:O60658 located_in GO:0005829"
xref: UniProtKB:O60658
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012486 ! high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
relationship: has_gene_template HGNC:8793 ! PDE8A (human)

[Term]
id: PR:O60658-2
name: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform h2 (human)
def: "A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60658-2." [PRO:DNx, UniProtKB:O60658]
comment: Category=organism-sequence.
synonym: "hPDE8A/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform PDE8A2 (human)" EXACT [UniProtKB:O60658]
xref: UniProtKB:O60658-2
is_a: PR:O60658 ! high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O60658-3
name: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform h3 (human)
def: "A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60658-3." [PRO:DNx, UniProtKB:O60658]
comment: Category=organism-sequence.
synonym: "hPDE8A/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform PDE8A3 (human)" EXACT [UniProtKB:O60658]
xref: UniProtKB:O60658-3
is_a: PR:O60658 ! high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O60658-1
name: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform h1 (human)
def: "A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60658-1." [PRO:DNx, UniProtKB:O60658]
comment: Category=organism-sequence.
synonym: "hPDE8A/iso:h1" EXACT PRO-short-label [PRO:DNx]
synonym: "high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform PDE8A1 (human)" EXACT [UniProtKB:O60658]
xref: UniProtKB:O60658-1
is_a: PR:O60658 ! high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O60658-6
name: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform h6 (human)
def: "A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60658-6." [PRO:DNx, UniProtKB:O60658]
comment: Category=organism-sequence.
synonym: "hPDE8A/iso:h6" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O60658-6
is_a: PR:O60658 ! high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O60658-4
name: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform h4 (human)
def: "A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60658-4." [PRO:DNx, UniProtKB:O60658]
comment: Category=organism-sequence.
synonym: "hPDE8A/iso:h4" EXACT PRO-short-label [PRO:DNx]
synonym: "high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform PDE8A4 (human)" EXACT [UniProtKB:O60658]
xref: UniProtKB:O60658-4
is_a: PR:O60658 ! high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O60658-5
name: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform h5 (human)
def: "A high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O60658-5." [PRO:DNx, UniProtKB:O60658]
comment: Category=organism-sequence.
synonym: "hPDE8A/iso:h5" EXACT PRO-short-label [PRO:DNx]
synonym: "high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform PDE8A5 (human)" EXACT [UniProtKB:O60658]
xref: UniProtKB:O60658-5
is_a: PR:O60658 ! high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens