[Term] id: PR:Q9Y2I7-3 name: 1-phosphatidylinositol 3-phosphate 5-kinase isoform h3 (human) def: "A 1-phosphatidylinositol 3-phosphate 5-kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y2I7-3." [PRO:DNx, UniProtKB:Q9Y2I7] comment: Category=organism-sequence. synonym: "hPIKFYVE/iso:h3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9Y2I7-3 is_a: PR:Q9Y2I7 ! 1-phosphatidylinositol 3-phosphate 5-kinase (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000048773 name: 1-phosphatidylinositol 3-phosphate 5-kinase, initiator methionine removed form (human) def: "A 1-phosphatidylinositol 3-phosphate 5-kinase (human) that has had the initiator methionine removed. UniProtKB:Q9Y2I7, 2-2098." [PRO:DNx, Reactome:R-HSA-1806191, Reactome:R-HSA-1806257, Reactome:R-HSA-1806280] comment: Category=organism-modification. synonym: "PRO_0000185452" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hPIKFYVE/InitMet-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q9Y2I7, 2-2098" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-1806191 "PR:000048773 located_in GO:0031902" xref: Reactome:R-HSA-1806257 "PR:000048773 located_in GO:0000139" xref: Reactome:R-HSA-1806280 "PR:000048773 located_in GO:0031901" intersection_of: lacks_part PR:000021937 ! initiator methionine intersection_of: PR:Q9Y2I7 ! 1-phosphatidylinositol 3-phosphate 5-kinase (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q9Y2I7-1 name: 1-phosphatidylinositol 3-phosphate 5-kinase isoform h1 (human) def: "A 1-phosphatidylinositol 3-phosphate 5-kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y2I7-1." [PRO:DNx, UniProtKB:Q9Y2I7] comment: Category=organism-sequence. synonym: "hPIKFYVE/iso:h1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9Y2I7-1 is_a: PR:Q9Y2I7 ! 1-phosphatidylinositol 3-phosphate 5-kinase (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O59722 name: 1-phosphatidylinositol 3-phosphate 5-kinase fab1 (Schizosaccharomyces pombe 972h-) def: "A 1-phosphatidylinositol 3-phosphate 5-kinase that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:O59722, PANTHER:PTHR11353:SF14, PRO:DNx] comment: Category=organism-gene. synonym: "fab1" RELATED Gene-based [UniProtKB:O59722] synonym: "ste12" RELATED Gene-based [UniProtKB:O59722] synonym: "SPBC3E7.01" RELATED Gene-based [UniProtKB:O59722] synonym: "SPBC6B1.11c" RELATED Gene-based [UniProtKB:O59722] synonym: "Spom972h-PIKFYVE" EXACT PRO-short-label [PRO:DNx] synonym: "PIPkin-III (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:O59722] synonym: "type III PIP kinase (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:O59722] synonym: "diphosphoinositide kinase (Schizosaccharomyces pombe 972h-)" RELATED [UniProtKB:O59722] synonym: "phosphatidylinositol 3-phosphate 5-kinase (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:O59722] xref: UniProtKB:O59722 intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h- intersection_of: PR:000012747 ! 1-phosphatidylinositol 3-phosphate 5-kinase relationship: has_gene_template PomBase:SPBC3E7.01 ! fab1 (Schizosaccharomyces pombe) [Term] id: PR:000012747 name: 1-phosphatidylinositol 3-phosphate 5-kinase def: "A protein that is a translation product of the human PIKFYVE gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "p235" BROAD [PRO:DNx] synonym: "PIP5K3" RELATED Gene-based [] synonym: "PIKFYVE" EXACT PRO-short-label [PRO:DNx] synonym: "PIKfyve" EXACT [] synonym: "KIAA0981" RELATED Gene-based [] synonym: "PIPkin-III" EXACT [] synonym: "type III PIP kinase" EXACT [] synonym: "serine-protein kinase PIKFYVE" EXACT [] synonym: "phosphatidylinositol 3-phosphate 5-kinase" EXACT [] synonym: "phosphatidylinositol-3-phosphate 5-kinase" EXACT [] synonym: "FYVE finger-containing phosphoinositide kinase" EXACT [] synonym: "phosphatidylinositol 3-phosphate 5-kinase type III" EXACT [] synonym: "phosphatidylinositol-3-phosphate 5-kinase type III" EXACT [] xref: IUPHARobj:2857 is_a: PR:000000001 ! protein [Term] id: PR:Q9Y2I7-2 name: 1-phosphatidylinositol 3-phosphate 5-kinase isoform h2 (human) def: "A 1-phosphatidylinositol 3-phosphate 5-kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y2I7-2." [PRO:DNx, UniProtKB:Q9Y2I7] comment: Category=organism-sequence. synonym: "hPIKFYVE/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9Y2I7-2 is_a: PR:Q9Y2I7 ! 1-phosphatidylinositol 3-phosphate 5-kinase (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000020979 name: 1-phosphatidylinositol 3-phosphate 5-kinase, initiator methionine removed form def: "A 1-phosphatidylinositol 3-phosphate 5-kinase that has had the initiator methionine removed." [PRO:DNx] comment: Category=modification. synonym: "PIP5K3/InitMet-" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000012747 ! 1-phosphatidylinositol 3-phosphate 5-kinase intersection_of: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:P34756 name: 1-phosphatidylinositol 3-phosphate 5-kinase FAB1 (yeast) def: "A 1-phosphatidylinositol 3-phosphate 5-kinase that is encoded in the genome of yeast." [OMA:P34756, PANTHER:PTHR11353:SF14, PRO:DNx] comment: Category=organism-gene. synonym: "FAB1" RELATED Gene-based [UniProtKB:P34756] synonym: "SVL7" RELATED Gene-based [UniProtKB:P34756] synonym: "YFR019W" RELATED Gene-based [UniProtKB:P34756] synonym: "yPIKFYVE" EXACT PRO-short-label [PRO:DNx] synonym: "PIPkin-III (yeast)" EXACT [UniProtKB:P34756] synonym: "type III PIP kinase (yeast)" EXACT [UniProtKB:P34756] synonym: "phosphatidylinositol 3-phosphate 5-kinase (yeast)" EXACT [UniProtKB:P34756] synonym: "styryl dye vacuolar localization protein 7 (yeast)" EXACT [UniProtKB:P34756] synonym: "formation of aploid and binucleate cells protein 1 (yeast)" EXACT [UniProtKB:P34756] xref: UniProtKB:P34756 intersection_of: only_in_taxon NCBITaxon:559292 ! Saccharomyces cerevisiae S288C intersection_of: PR:000012747 ! 1-phosphatidylinositol 3-phosphate 5-kinase relationship: has_gene_template SGD:S000001915 ! FAB1 (yeast) [Term] id: PR:Q9Z1T6 name: 1-phosphatidylinositol 3-phosphate 5-kinase (mouse) def: "A 1-phosphatidylinositol 3-phosphate 5-kinase that is encoded in the genome of mouse." [OMA:Q9Z1T6, PRO:DNx] comment: Category=organism-gene. synonym: "Fab1" RELATED Gene-based [UniProtKB:Q9Z1T6] synonym: "Pip5k3" RELATED Gene-based [UniProtKB:Q9Z1T6] synonym: "Pikfyve" RELATED Gene-based [UniProtKB:Q9Z1T6] synonym: "Kiaa0981" RELATED Gene-based [UniProtKB:Q9Z1T6] synonym: "mPIKFYVE" EXACT PRO-short-label [PRO:DNx] synonym: "p235 (mouse)" BROAD [UniProtKB:Q9Z1T6] synonym: "PIKfyve (mouse)" EXACT [UniProtKB:Q9Z1T6] synonym: "PIPkin-III (mouse)" EXACT [UniProtKB:Q9Z1T6] synonym: "type III PIP kinase (mouse)" EXACT [UniProtKB:Q9Z1T6] synonym: "serine-protein kinase PIKFYVE (mouse)" EXACT [UniProtKB:Q9Z1T6] synonym: "phosphatidylinositol 3-phosphate 5-kinase (mouse)" EXACT [UniProtKB:Q9Z1T6] synonym: "FYVE finger-containing phosphoinositide kinase (mouse)" EXACT [UniProtKB:Q9Z1T6] synonym: "phosphatidylinositol 3-phosphate 5-kinase type III (mouse)" EXACT [UniProtKB:Q9Z1T6] xref: UniProtKB:Q9Z1T6 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000012747 ! 1-phosphatidylinositol 3-phosphate 5-kinase relationship: has_gene_template MGI:1335106 ! Pikfyve (mouse) [Term] id: PR:Q9Z1T6-2 name: 1-phosphatidylinositol 3-phosphate 5-kinase isoform m1 (mouse) def: "A 1-phosphatidylinositol 3-phosphate 5-kinase (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z1T6-2." [PRO:DNx, UniProtKB:Q9Z1T6] comment: Category=organism-sequence. synonym: "mPIKFYVE/iso:m1" EXACT PRO-short-label [PRO:DNx] synonym: "1-phosphatidylinositol 3-phosphate 5-kinase isoform p235S (mouse)" EXACT [UniProtKB:Q9Z1T6] xref: UniProtKB:Q9Z1T6-2 is_a: PR:Q9Z1T6 ! 1-phosphatidylinositol 3-phosphate 5-kinase (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:Q9Y2I7 name: 1-phosphatidylinositol 3-phosphate 5-kinase (human) def: "A 1-phosphatidylinositol 3-phosphate 5-kinase that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q9Y2I7] comment: Category=organism-gene. synonym: "PIP5K3" RELATED Gene-based [UniProtKB:Q9Y2I7] synonym: "PIKFYVE" RELATED Gene-based [UniProtKB:Q9Y2I7] synonym: "KIAA0981" RELATED Gene-based [UniProtKB:Q9Y2I7] synonym: "hPIKFYVE" EXACT PRO-short-label [PRO:DNx] synonym: "PIKfyve (human)" EXACT [UniProtKB:Q9Y2I7] synonym: "PIPkin-III (human)" EXACT [UniProtKB:Q9Y2I7] synonym: "type III PIP kinase (human)" EXACT [UniProtKB:Q9Y2I7] synonym: "serine-protein kinase PIKFYVE (human)" EXACT [UniProtKB:Q9Y2I7] synonym: "phosphatidylinositol 3-phosphate 5-kinase (human)" EXACT [UniProtKB:Q9Y2I7] synonym: "FYVE finger-containing phosphoinositide kinase (human)" EXACT [UniProtKB:Q9Y2I7] synonym: "phosphatidylinositol 3-phosphate 5-kinase type III (human)" EXACT [UniProtKB:Q9Y2I7] xref: DTO:03100157 xref: UniProtKB:Q9Y2I7 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000012747 ! 1-phosphatidylinositol 3-phosphate 5-kinase relationship: has_gene_template HGNC:23785 ! PIKFYVE (human) [Term] id: PR:000046097 name: 1-phosphatidylinositol 3-phosphate 5-kinase phosphorylated 1 (human) def: "A 1-phosphatidylinositol 3-phosphate 5-kinase (human) that has been phosphorylated on the residue at the position equivalent to Ser-318 of the amino acid sequence represented by UniProtKB:Q9Y2I7-1. Example: UniProtKB:Q9Y2I7-1, Ser-318, MOD:00046." [PMID:20513353, iPTMnet:Q9Y2I7] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:20513353). Status=unreviewed. synonym: "hPIKFYVE/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q9Y2I7-1, Ser-318, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:Q9Y2I7 ! 1-phosphatidylinositol 3-phosphate 5-kinase (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q9Z1T6-1 name: 1-phosphatidylinositol 3-phosphate 5-kinase isoform m2 (mouse) def: "A 1-phosphatidylinositol 3-phosphate 5-kinase (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z1T6-1." [PRO:DNx, UniProtKB:Q9Z1T6] comment: Category=organism-sequence. synonym: "mPIKFYVE/iso:m2" EXACT PRO-short-label [PRO:DNx] synonym: "1-phosphatidylinositol 3-phosphate 5-kinase isoform p235L (mouse)" EXACT [UniProtKB:Q9Z1T6] xref: UniProtKB:Q9Z1T6-1 is_a: PR:Q9Z1T6 ! 1-phosphatidylinositol 3-phosphate 5-kinase (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:Q9Y2I7-4 name: 1-phosphatidylinositol 3-phosphate 5-kinase isoform h4 (human) def: "A 1-phosphatidylinositol 3-phosphate 5-kinase (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Y2I7-4." [PRO:DNx, UniProtKB:Q9Y2I7] comment: Category=organism-sequence. synonym: "hPIKFYVE/iso:h4" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9Y2I7-4 is_a: PR:Q9Y2I7 ! 1-phosphatidylinositol 3-phosphate 5-kinase (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q9Z1T6-3 name: 1-phosphatidylinositol 3-phosphate 5-kinase isoform m3 (mouse) def: "A 1-phosphatidylinositol 3-phosphate 5-kinase (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9Z1T6-3." [PRO:DNx, UniProtKB:Q9Z1T6] comment: Category=organism-sequence. synonym: "mPIKFYVE/iso:m3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9Z1T6-3 is_a: PR:Q9Z1T6 ! 1-phosphatidylinositol 3-phosphate 5-kinase (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:Q0WUR5-1 name: 1-phosphatidylinositol-3-phosphate 5-kinase FAB1A isoform 1 (Arabidopsis thaliana) def: "A 1-phosphatidylinositol-3-phosphate 5-kinase FAB1A (Arabidopsis thaliana) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q0WUR5-1." [PRO:DNx, UniProtKB:Q0WUR5] comment: Category=organism-sequence. synonym: "At-PIKFYVE/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q0WUR5-1 is_a: PR:Q0WUR5 ! 1-phosphatidylinositol-3-phosphate 5-kinase FAB1A (Arabidopsis thaliana) relationship: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana [Term] id: PR:O96838 name: putative 1-phosphatidylinositol 3-phosphate 5-kinase (fruit fly) def: "A 1-phosphatidylinositol 3-phosphate 5-kinase that is encoded in the genome of fruit fly." [OMA:O96838, PANTHER:PTHR11353:SF14, PRO:DNx] comment: Category=organism-gene. synonym: "fab1" RELATED Gene-based [UniProtKB:O96838] synonym: "CG6355" RELATED Gene-based [UniProtKB:O96838] synonym: "fly-PIKFYVE" EXACT PRO-short-label [PRO:DNx] synonym: "PIPkin-III (fruit fly)" EXACT [UniProtKB:O96838] synonym: "type III PIP kinase (fruit fly)" EXACT [UniProtKB:O96838] synonym: "phosphatidylinositol 3-phosphate 5-kinase (fruit fly)" EXACT [UniProtKB:O96838] xref: UniProtKB:O96838 intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster intersection_of: PR:000012747 ! 1-phosphatidylinositol 3-phosphate 5-kinase relationship: has_gene_template FlyBase:FBgn0028741 ! fab1 (fruit fly) [Term] id: PR:Q0WUR5 name: 1-phosphatidylinositol-3-phosphate 5-kinase FAB1A (Arabidopsis thaliana) def: "A 1-phosphatidylinositol 3-phosphate 5-kinase that is encoded in the genome of Arabidopsis thaliana." [PANTHER:PTHR11353:SF14, PRO:DNx] comment: Category=organism-gene. synonym: "FAB1A" RELATED Gene-based [UniProtKB:Q0WUR5] synonym: "At4g33240" RELATED Gene-based [UniProtKB:Q0WUR5] synonym: "F4I10.170" RELATED Gene-based [UniProtKB:Q0WUR5] synonym: "At-PIKFYVE" EXACT PRO-short-label [PRO:DNx] synonym: "PIKfyve (Arabidopsis thaliana)" RELATED [UniProtKB:Q0WUR5] synonym: "PIPkin-III (Arabidopsis thaliana)" BROAD [UniProtKB:Q0WUR5] synonym: "type III PIP kinase (Arabidopsis thaliana)" BROAD [UniProtKB:Q0WUR5] synonym: "phosphatidylinositol 3-phosphate 5-kinase (Arabidopsis thaliana)" BROAD [UniProtKB:Q0WUR5] synonym: "protein FORMS APLOID AND BINUCLEATE CELLS 1A (Arabidopsis thaliana)" EXACT [UniProtKB:Q0WUR5] synonym: "FYVE finger-containing phosphoinositide kinase (Arabidopsis thaliana)" RELATED [UniProtKB:Q0WUR5] synonym: "phosphatidylinositol 3-phosphate 5-kinase type III (Arabidopsis thaliana)" BROAD [UniProtKB:Q0WUR5] xref: UniProtKB:Q0WUR5 intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana intersection_of: PR:000012747 ! 1-phosphatidylinositol 3-phosphate 5-kinase relationship: has_gene_template Araport:AT4G33240 ! FAB1A (Arabidopsis thaliana)