[Term] id: PR:000012826 name: urokinase-type plasminogen activator def: "A protein that is a translation product of the human PLAU gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "uPA" EXACT [] synonym: "PLAU" EXACT PRO-short-label [PRO:DNx] synonym: "U-plasminogen activator" EXACT [] xref: IUPHARobj:2393 is_a: PR:000000001 ! protein [Term] id: PR:000048797 name: urokinase-type plasminogen activator, signal peptide removed form (human) def: "A urokinase-type plasminogen activator (human) that has had the signal peptide removed. UniProtKB:P00749, 21-431." [PRO:DNx, Reactome:R-HSA-158945, Reactome:R-HSA-158979] comment: Category=organism-modification. synonym: "hPLAU/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000028318" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P00749, 21-431" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-158945 "PR:000048797 located_in GO:0005886" xref: Reactome:R-HSA-158979 "PR:000048797 located_in GO:0005576" xref: Reactome:R-HSA-6799705 "PR:000048797 located_in GO:0035579" xref: Reactome:R-HSA-6800974 "PR:000048797 located_in GO:0070821" intersection_of: PR:P00749 ! urokinase-type plasminogen activator (human) intersection_of: lacks_part SO:0000418 ! signal_peptide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000021003 name: urokinase-type plasminogen activator proteolytic cleavage product def: "A urokinase-type plasminogen activator that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "PLAU/ClvPrd" EXACT PRO-short-label [PRO:DNx] intersection_of: output_of GO:0016485 ! protein processing intersection_of: PR:000012826 ! urokinase-type plasminogen activator [Term] id: PR:000021002 name: urokinase-type plasminogen activator, signal peptide removed form def: "A urokinase-type plasminogen activator that has had the signal peptide removed." [PRO:DNx] comment: Category=modification. synonym: "PLAU/SigPep-" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000012826 ! urokinase-type plasminogen activator intersection_of: lacks_part SO:0000418 ! signal_peptide [Term] id: PR:P00749-2 name: urokinase-type plasminogen activator isoform h2 (human) def: "A urokinase-type plasminogen activator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00749-2." [PRO:DNx, UniProtKB:P00749] comment: Category=organism-sequence. synonym: "hPLAU/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P00749-2 is_a: PR:P00749 ! urokinase-type plasminogen activator (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P29598 name: urokinase-type plasminogen activator (rat) def: "A urokinase-type plasminogen activator that is encoded in the genome of rat." [OMA:P29598, PRO:DNx] comment: Category=organism-gene. synonym: "Plau" RELATED Gene-based [UniProtKB:P29598] synonym: "rPLAU" EXACT PRO-short-label [PRO:DNx] synonym: "uPA (rat)" EXACT [UniProtKB:P29598] synonym: "U-plasminogen activator (rat)" EXACT [UniProtKB:P29598] xref: UniProtKB:P29598 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000012826 ! urokinase-type plasminogen activator relationship: has_gene_template RGD:3343 ! Plau (rat) [Term] id: PR:P00749-1 name: urokinase-type plasminogen activator isoform 1 (human) def: "A urokinase-type plasminogen activator (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P00749-1." [PRO:DNx, UniProtKB:P00749] comment: Category=organism-sequence. Requested by=PubChem. synonym: "hPLAU/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P00749-1 is_a: PR:P00749 ! urokinase-type plasminogen activator (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P06869 name: urokinase-type plasminogen activator (mouse) def: "A urokinase-type plasminogen activator that is encoded in the genome of mouse." [OMA:P06869, PRO:DNx] comment: Category=organism-gene. Requested by=PubChem. synonym: "Plau" RELATED Gene-based [UniProtKB:P06869] synonym: "mPLAU" EXACT PRO-short-label [PRO:DNx] synonym: "uPA (mouse)" EXACT [UniProtKB:P06869] synonym: "U-plasminogen activator (mouse)" EXACT [UniProtKB:P06869] xref: UniProtKB:P06869 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000012826 ! urokinase-type plasminogen activator relationship: has_gene_template MGI:97611 ! Plau (mouse) [Term] id: PR:P15120 name: urokinase-type plasminogen activator (chicken) def: "A urokinase-type plasminogen activator that is encoded in the genome of chicken." [OMA:P15120, PRO:DNx] comment: Category=organism-gene. synonym: "PLAU" RELATED Gene-based [UniProtKB:P15120] synonym: "chick-PLAU" EXACT PRO-short-label [PRO:DNx] synonym: "uPA (chicken)" EXACT [UniProtKB:P15120] synonym: "U-plasminogen activator (chicken)" EXACT [UniProtKB:P15120] xref: UniProtKB:P15120 intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus intersection_of: PR:000012826 ! urokinase-type plasminogen activator relationship: has_gene_template CGNC:3784 ! PLAU (chicken) [Term] id: PR:P00749 name: urokinase-type plasminogen activator (human) def: "A urokinase-type plasminogen activator that is encoded in the genome of human." [PRO:DNx, UniProtKB:P00749] comment: Category=organism-gene. synonym: "PLAU" RELATED Gene-based [UniProtKB:P00749] synonym: "hPLAU" EXACT PRO-short-label [PRO:DNx] synonym: "uPA (human)" EXACT [UniProtKB:P00749] synonym: "U-plasminogen activator (human)" EXACT [UniProtKB:P00749] xref: UniProtKB:P00749 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000012826 ! urokinase-type plasminogen activator relationship: has_gene_template HGNC:9052 ! PLAU (human)