[Term]
id: PR:000044818
name: serine/threonine-protein kinase PLK1 phosphorylated 1 (human)
def: "A serine/threonine-protein kinase PLK1 (human) that has been phosphorylated on a Ser residue that is within a 14-3-3 recognition motif, and a Thr residue that is in the activation loop and is an Aurora kinase phosphorylation site. UniProtKB:P53350, Ser-99, MOD:00046|Thr-210, MOD:00047." [PMID:23695676, PRO:CNA]
comment: Category=organism-modification. Evidence=(ECO:0000006, PMID:23695676). Kinase=("AKT"; PR:000029189; Ser-99). Kinase=("AURKA"; PR:O14965; Thr-210). Note: Proteoform created based on papers selected via the eFIP text mining tool.
synonym: "hPLK1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P53350, Ser-99, MOD:00046|Thr-210, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P53350 ! serine/threonine-protein kinase PLK1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000035669
name: serine/threonine-protein kinase PLK1 unphosphorylated form (human)
def: "A serine/threonine-protein kinase PLK1 unphosphorylated form in human." [PRO:KER]
comment: Category=organism-modification.
synonym: "hPLK1/PhosRes-" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000035668 ! serine/threonine-protein kinase PLK1 unphosphorylated form

[Term]
id: PR:000045826
name: serine/threonine-protein kinase PLK1 phosphorylated 2 (human)
def: "A serine/threonine-protein kinase PLK1 (human) that has been phosphorylated at Ser-49. UniProtKB:P53350, Ser-49, MOD:00046." [PMID:18427546, iPTMnet:P53350]
comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:18427546). Status=unreviewed.
synonym: "hPLK1/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P53350, Ser-49, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P53350 ! serine/threonine-protein kinase PLK1 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P53350-1
name: serine/threonine-protein kinase PLK1 isoform 1 (human)
def: "A serine/threonine-protein kinase PLK1 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPLK1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P53350-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039726 ! serine/threonine-protein kinase PLK1 isoform 1

[Term]
id: PR:000012870
name: serine/threonine-protein kinase PLK1
def: "A protein that is a translation product of the human PLK1 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "PLK" RELATED Gene-based []
synonym: "PLK1" EXACT PRO-short-label [PRO:DNx]
synonym: "PLK-1" EXACT []
synonym: "STPK13" EXACT []
synonym: "Polo-like kinase 1" EXACT []
synonym: "serine/threonine-protein kinase 13" RELATED []
xref: IUPHARobj:2168
is_a: PR:000000001 ! protein

[Term]
id: PR:P53350
name: serine/threonine-protein kinase PLK1 (human)
def: "A serine/threonine-protein kinase PLK1 that is encoded in the genome of human." [PMID:16129782, PMID:16580887, PMID:16760428, PMID:17376779, PMID:20624902, PMID:20823832, PRO:KER]
comment: Category=organism-gene.
synonym: "PLK" RELATED Gene-based [UniProtKB:P53350]
synonym: "PLK1" RELATED Gene-based [UniProtKB:P53350]
synonym: "hPLK1" EXACT PRO-short-label [PRO:DNx]
synonym: "PLK-1 (human)" EXACT [UniProtKB:P53350]
synonym: "STPK13 (human)" EXACT [UniProtKB:P53350]
synonym: "Polo-like kinase 1 (human)" EXACT [UniProtKB:P53350]
synonym: "serine/threonine-protein kinase 13 (human)" BROAD [UniProtKB:P53350]
xref: Reactome:R-HSA-156720 "PR:P53350 located_in GO:0005654"
xref: Reactome:R-HSA-164603 "PR:P53350 located_in GO:0005829"
xref: DTO:03100430
xref: UniProtKB:P53350
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000012870 ! serine/threonine-protein kinase PLK1
relationship: has_gene_template HGNC:9077 ! PLK1 (human)

[Term]
id: PR:000048813
name: serine/threonine-protein kinase PLK1 phosphorylated 3 (human)
def: "A serine/threonine-protein kinase PLK1 (human) that has been phosphorylated on the residue at the position equivalent to Thr-210 of the amino acid sequence represented by UniProtKB:P53350. UniProtKB:P53350, Thr-210, MOD:00047." [PRO:DNx, Reactome:R-HSA-3000318, Reactome:R-HSA-3002800]
comment: Category=organism-modification.
synonym: "hPLK1/Phos:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P53350, Thr-210, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-3000318 "PR:000048813 located_in GO:0005829"
xref: Reactome:R-HSA-3002800 "PR:000048813 located_in GO:0005654"
is_a: PR:P53350 ! serine/threonine-protein kinase PLK1 (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens