[Term] id: PR:P24928-1 name: DNA-directed RNA polymerase II subunit RPB1 isoform 1 (human) def: "A DNA-directed RNA polymerase II subunit RPB1 isoform 1 that is encoded in the genome of human." [PRO:DNx] comment: Category=organism-sequence. synonym: "hPOLR2A/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P24928-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000039128 ! DNA-directed RNA polymerase II subunit RPB1 isoform 1 [Term] id: PR:P24928-2 name: DNA-directed RNA polymerase II subunit RPB1 isoform h2 (human) def: "A DNA-directed RNA polymerase II subunit RPB1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P24928-2." [PRO:DNx, UniProtKB:P24928] comment: Category=organism-sequence. synonym: "hPOLR2A/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P24928-2 is_a: PR:P24928 ! DNA-directed RNA polymerase II subunit RPB1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000012987 name: DNA-directed RNA polymerase II subunit RPB1 def: "A protein that is a translation product of the human POLR2A gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "POLR2" RELATED Gene-based [] synonym: "POLR2A" EXACT PRO-short-label [PRO:DNx] synonym: "Rpo2-1" RELATED Gene-based [] synonym: "Rpii215" RELATED Gene-based [] synonym: "RNA polymerase II subunit B1" EXACT [] synonym: "DNA-directed RNA polymerase II subunit A" EXACT [] synonym: "RNA-directed RNA polymerase II subunit RPB1" EXACT [] synonym: "DNA-directed RNA polymerase III largest subunit" RELATED [] is_a: PR:000000001 ! protein [Term] id: PR:P24928 name: DNA-directed RNA polymerase II subunit RPB1 (human) def: "A DNA-directed RNA polymerase II subunit RPB1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P24928] comment: Category=organism-gene. synonym: "POLR2" RELATED Gene-based [UniProtKB:P24928] synonym: "POLR2A" RELATED Gene-based [UniProtKB:P24928] synonym: "hPOLR2A" EXACT PRO-short-label [PRO:DNx] synonym: "RNA polymerase II subunit B1 (human)" EXACT [UniProtKB:P24928] synonym: "DNA-directed RNA polymerase II subunit A (human)" EXACT [UniProtKB:P24928] synonym: "RNA-directed RNA polymerase II subunit RPB1 (human)" EXACT [UniProtKB:P24928] synonym: "DNA-directed RNA polymerase III largest subunit (human)" BROAD [UniProtKB:P24928] xref: Reactome:R-HSA-63502 "PR:P24928 located_in GO:0005654" xref: UniProtKB:P24928 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000012987 ! DNA-directed RNA polymerase II subunit RPB1 relationship: has_gene_template HGNC:9187 ! POLR2A (human) [Term] id: PR:000048850 name: DNA-directed RNA polymerase II subunit RPB1 phosphoserine form (human) def: "A DNA-directed RNA polymerase II subunit RPB1 (human) that includes at least one phosphorylated serine. UniProtKB:P24928, MOD:00046." [PRO:DNx, Reactome:R-HSA-6797701] comment: Category=organism-modification. synonym: "hPOLR2A/PhosSer+" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P24928, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-6797701 "PR:000048850 located_in GO:0005654" intersection_of: has_part MOD:00046 ! O-phospho-L-serine intersection_of: PR:P24928 ! DNA-directed RNA polymerase II subunit RPB1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000048846 name: DNA-directed RNA polymerase II subunit RPB1 phosphorylated 1 (human) def: "A DNA-directed RNA polymerase II subunit RPB1 (human) that has been post-translationally modified to include phosphoserine at the second and fifth positions of one or more of the C-terminal heptad repeats (YSPTSPS) of the amino acid sequence represented by UniProtKB:P24928. Example: UniProtKB:P24928-1, Ser-1791/Ser-1794, MOD:00046." [PRO:DAN, Reactome:R-HSA-113420] comment: Category=organism-modification. synonym: "hPOLR2A/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P24928-1, Ser-1791/Ser-1794, MOD:00046" NARROW PRO-proteoform-std [PRO:DAN] xref: Reactome:R-HSA-113420 "PR:000048846 located_in GO:0005654" is_a: PR:P24928 ! DNA-directed RNA polymerase II subunit RPB1 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000048847 name: DNA-directed RNA polymerase II subunit RPB1 phosphorylated 2 (human) def: "A DNA-directed RNA polymerase II subunit RPB1 (human) that has been post-translationally modified to include phosphoserine at the second and seventh positions of one or more of the C-terminal heptad repeats (YSPTSPS) of the amino acid sequence represented by UniProtKB:P24928. Example: UniProtKB:P24928-1, Ser-1791/Ser-1796, MOD:00046." [PRO:DAN, Reactome:R-HSA-6814543] comment: Category=organism-modification. synonym: "hPOLR2A/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P24928-1, Ser-1791/Ser-1796, MOD:00046" NARROW PRO-proteoform-std [PRO:DAN] xref: Reactome:R-HSA-6814543 "PR:000048847 located_in GO:0005654" is_a: PR:P24928 ! DNA-directed RNA polymerase II subunit RPB1 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000048848 name: DNA-directed RNA polymerase II subunit RPB1 phosphorylated 3 (human) def: "A DNA-directed RNA polymerase II subunit RPB1 (human) that has been post-translationally modified to include phosphoserine at the fifth position of one or more of the C-terminal heptad repeats (YSPTSPS) of the amino acid sequence represented by UniProtKB:P24928. Example: UniProtKB:P24928-1, Ser-1794, MOD:00046." [PRO:DAN, Reactome:R-HSA-77100] comment: Category=organism-modification. synonym: "hPOLR2A/Phos:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P24928-1, Ser-1794, MOD:00046" NARROW PRO-proteoform-std [PRO:DAN] xref: Reactome:R-HSA-77100 "PR:000048848 located_in GO:0005654" is_a: PR:P24928 ! DNA-directed RNA polymerase II subunit RPB1 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000048849 name: DNA-directed RNA polymerase II subunit RPB1 phosphorylated 4 (human) def: "A DNA-directed RNA polymerase II subunit RPB1 (human) that has been post-translationally modified to include phosphoserine at the fifth and seventh positions of one or more of the C-terminal heptad repeats (YSPTSPS) of the amino acid sequence represented by UniProtKB:P24928. Example: UniProtKB:P24928-1, Ser-1794/Ser-1796, MOD:00046." [PRO:DAN, Reactome:R-HSA-6810226] comment: Category=organism-modification. synonym: "hPOLR2A/Phos:4" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P24928-1, Ser-1794/Ser-1796, MOD:00046" NARROW PRO-proteoform-std [PRO:DAN] xref: Reactome:R-HSA-6810226 "PR:000048849 located_in GO:0005654" is_a: PR:P24928 ! DNA-directed RNA polymerase II subunit RPB1 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens