[Term]
id: PR:O14744
name: protein arginine N-methyltransferase 5 (human)
def: "A protein arginine N-methyltransferase 5 that is encoded in the genome of human." [PRO:DNx, UniProtKB:O14744]
comment: Category=organism-gene.
synonym: "JBP1" RELATED Gene-based [UniProtKB:O14744]
synonym: "SKB1" RELATED Gene-based [UniProtKB:O14744]
synonym: "IBP72" RELATED Gene-based [UniProtKB:O14744]
synonym: "PRMT5" RELATED Gene-based [UniProtKB:O14744]
synonym: "hPRMT5" EXACT PRO-short-label [PRO:DNx]
synonym: "HRMT1L5" RELATED Gene-based [UniProtKB:O14744]
synonym: "SKB1Hs (human)" EXACT [UniProtKB:O14744]
synonym: "SKB1 homolog (human)" EXACT [UniProtKB:O14744]
synonym: "Jak-binding protein 1 (human)" EXACT [UniProtKB:O14744]
synonym: "72 kDa ICln-binding protein (human)" EXACT [UniProtKB:O14744]
synonym: "Shk1 kinase-binding protein 1 homolog (human)" EXACT [UniProtKB:O14744]
synonym: "histone-arginine N-methyltransferase PRMT5 (human)" EXACT [UniProtKB:O14744]
xref: Reactome:R-HSA-191876 "PR:O14744 located_in GO:0005829"
xref: Reactome:R-HSA-5205609 "PR:O14744 located_in GO:0005654"
xref: UniProtKB:O14744
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000013255 ! protein arginine N-methyltransferase 5
relationship: has_gene_template HGNC:10894 ! PRMT5 (human)

[Term]
id: PR:000013255
name: protein arginine N-methyltransferase 5
def: "A protein that is a translation product of the human PRMT5 gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "JBP1" RELATED Gene-based []
synonym: "SKB1" RELATED Gene-based []
synonym: "IBP72" RELATED Gene-based []
synonym: "PRMT5" EXACT PRO-short-label [PRO:DNx]
synonym: "SKB1Hs" EXACT []
synonym: "HRMT1L5" RELATED Gene-based []
synonym: "SKB1 homolog" EXACT []
synonym: "Jak-binding protein 1" EXACT []
synonym: "72 kDa ICln-binding protein" EXACT []
synonym: "shk1 kinase-binding protein 1 homolog" EXACT []
synonym: "histone-arginine N-methyltransferase PRMT5" EXACT []
xref: IUPHARobj:1256
is_a: PR:000000001 ! protein

[Term]
id: PR:000048929
name: protein arginine N-methyltransferase 5 phosphorylated 1 (human)
def: "A protein arginine N-methyltransferase 5 (human) that has been post-translationally modified to include phosphotyrosine at positions 297, 304 and 307 of the amino acid sequence represented by UniProtKB:O14744. UniProtKB:O14744, Tyr-297/Tyr-304/Tyr-307, MOD:00048." [PRO:DNx, Reactome:R-HSA-5211300]
comment: Category=organism-modification.
synonym: "hPRMT5/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O14744, Tyr-297/Tyr-304/Tyr-307, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5211300 "PR:000048929 located_in GO:0005654"
is_a: PR:O14744 ! protein arginine N-methyltransferase 5 (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O14744-5
name: protein arginine N-methyltransferase 5 isoform h5 (human)
def: "A protein arginine N-methyltransferase 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14744-5." [PRO:DNx, UniProtKB:O14744]
comment: Category=organism-sequence.
synonym: "hPRMT5/iso:h5" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O14744-5
is_a: PR:O14744 ! protein arginine N-methyltransferase 5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O14744-4
name: protein arginine N-methyltransferase 5 isoform h4 (human)
def: "A protein arginine N-methyltransferase 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14744-4." [PRO:DNx, UniProtKB:O14744]
comment: Category=organism-sequence.
synonym: "hPRMT5/iso:h4" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O14744-4
is_a: PR:O14744 ! protein arginine N-methyltransferase 5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O14744-3
name: protein arginine N-methyltransferase 5 isoform h3 (human)
def: "A protein arginine N-methyltransferase 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14744-3." [PRO:DNx, UniProtKB:O14744]
comment: Category=organism-sequence.
synonym: "hPRMT5/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O14744-3
is_a: PR:O14744 ! protein arginine N-methyltransferase 5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O14744-2
name: protein arginine N-methyltransferase 5 isoform h2 (human)
def: "A protein arginine N-methyltransferase 5 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O14744-2." [PRO:DNx, UniProtKB:O14744]
comment: Category=organism-sequence.
synonym: "hPRMT5/iso:h2" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O14744-2
is_a: PR:O14744 ! protein arginine N-methyltransferase 5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O14744-1
name: protein arginine N-methyltransferase 5 isoform 1 (human)
def: "A protein arginine N-methyltransferase 5 isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hPRMT5/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O14744-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000037995 ! protein arginine N-methyltransferase 5 isoform 1