[Term] id: PR:000035919 name: vitamin K-dependent protein C activation peptide (human) def: "A vitamin K-dependent protein C activation peptide in human. UniProtKB:P04070, 200-211." [PMID:2405901, PMID:468991, PMID:6589623, Reactome:R-HSA-141051] comment: Category=organism-modification. synonym: "PRO_0000028111" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hPROC/Clv:act_pep" EXACT PRO-short-label [PRO:DAN] synonym: "UniProtKB:P04070, 200-211" EXACT PRO-proteoform-std [PRO:DNx] synonym: "protein C heavy chain activation peptide" EXACT [] xref: Reactome:R-HSA-141051 "PR:000035919 located_in GO:0005576" intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000035918 ! vitamin K-dependent protein C activation peptide [Term] id: PR:000021105 name: vitamin K-dependent protein C proteolytic cleavage product def: "A vitamin K-dependent protein C that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "PROC/ClvPrd" EXACT PRO-short-label [PRO:DNx] intersection_of: output_of GO:0016485 ! protein processing intersection_of: PR:000013261 ! vitamin K-dependent protein C [Term] id: PR:P31394 name: vitamin K-dependent protein C (rat) def: "A vitamin K-dependent protein C that is encoded in the genome of rat." [OMA:P31394, PANTHER:PTHR24278:SF62, PRO:DNx] comment: Category=organism-gene. synonym: "Proc" RELATED Gene-based [UniProtKB:P31394] synonym: "rPROC" EXACT PRO-short-label [PRO:DNx] synonym: "autoprothrombin IIA (rat)" EXACT [UniProtKB:P31394] synonym: "anticoagulant protein C (rat)" EXACT [UniProtKB:P31394] synonym: "blood coagulation factor XIV (rat)" EXACT [UniProtKB:P31394] xref: UniProtKB:P31394 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000013261 ! vitamin K-dependent protein C relationship: has_gene_template RGD:3411 ! Proc (rat) [Term] id: PR:P04070 name: vitamin K-dependent protein C (human) def: "A vitamin K-dependent protein C that is encoded in the genome of human." [PRO:DNx, UniProtKB:P04070] comment: Category=organism-gene. synonym: "PROC" RELATED Gene-based [UniProtKB:P04070] synonym: "hPROC" EXACT PRO-short-label [PRO:DNx] synonym: "autoprothrombin IIA (human)" EXACT [UniProtKB:P04070] synonym: "anticoagulant protein C (human)" EXACT [UniProtKB:P04070] synonym: "blood coagulation factor XIV (human)" EXACT [UniProtKB:P04070] xref: UniProtKB:P04070 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000013261 ! vitamin K-dependent protein C relationship: has_gene_template HGNC:9451 ! PROC (human) [Term] id: PR:000021104 name: vitamin K-dependent protein C, signal peptide removed form def: "A vitamin K-dependent protein C that has had the signal peptide removed." [PRO:DNx] comment: Category=modification. synonym: "PROC/SigPep-" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000013261 ! vitamin K-dependent protein C intersection_of: lacks_part SO:0000418 ! signal_peptide [Term] id: PR:000013261 name: vitamin K-dependent protein C def: "A protein that is a translation product of the human PROC gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "PROC" EXACT PRO-short-label [PRO:DNx] synonym: "autoprothrombin IIA" EXACT [] synonym: "anticoagulant protein C" EXACT [] synonym: "blood coagulation factor XIV" EXACT [] xref: IUPHARobj:2396 is_a: PR:000000001 ! protein [Term] id: PR:000026178 name: pro-protein C light chain (human) def: "A pro-protein C light chain in human. UniProtKB:P04070, 19-197, Glu-48/Glu-49/Glu-56/Glu-58/Glu-61/Glu-62/Glu-67/Glu-68/Glu-71, MOD:00041|Asp-113, MOD:00036." [PMID:2991887, PRO:CNx, PRO:DAN] comment: Category=organism-modification. synonym: "hPROC/Clv:proL" EXACT PRO-short-label [PRO:DAN] synonym: "UniProtKB:P04070, 19-197, Glu-48/Glu-49/Glu-56/Glu-58/Glu-61/Glu-62/Glu-67/Glu-68/Glu-71, MOD:00041|Asp-113, MOD:00036" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000026177 ! pro-protein C light chain relationship: has_part MOD:00036 ! (2S,3R)-3-hydroxyaspartic acid relationship: has_part MOD:00041 ! L-gamma-carboxyglutamic acid [Term] id: PR:P33587-1 name: vitamin K-dependent protein C isoform 1 (mouse) def: "A vitamin K-dependent protein C isoform 1 that is encoded in the genome of mouse." [PRO:CNx] comment: Category=organism-sequence. synonym: "mPROC/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P33587-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000026175 ! vitamin K-dependent protein C isoform 1 [Term] id: PR:000035921 name: vitamin K-dependent protein C heavy chain (human) def: "A vitamin K-dependent protein C heavy chain in human. UniProtKB:P04070, 200-461." [PMID:2405901, PMID:6589623, Reactome:R-HSA-141042, Reactome:R-HSA-159780, Reactome:R-HSA-159827] comment: Category=organism-modification. synonym: "hPROC/Clv:H" EXACT PRO-short-label [PRO:DAN] synonym: "PRO_0000028110" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P04070, 200-461" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-141042 "PR:000035921 located_in GO:0005576" xref: Reactome:R-HSA-159780 "PR:000035921 located_in GO:0005788" xref: Reactome:R-HSA-159827 "PR:000035921 located_in GO:0005796" intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000035920 ! vitamin K-dependent protein C heavy chain [Term] id: PR:000035920 name: vitamin K-dependent protein C heavy chain def: "A vitamin K-dependent protein C proteolytic cleavage product that is the C-terminal region encompassing the activation peptide and the Trypsin (Pfam:PF00089) domain. Example: UniProtKB:P04070, 200-461." [PMID:2405901, PMID:6589623, Reactome:R-HSA-141042, Reactome:R-HSA-159780, Reactome:R-HSA-159827] comment: Category=modification. synonym: "PROC/Clv:H" EXACT PRO-short-label [PRO:DAN] is_a: PR:000021105 ! vitamin K-dependent protein C proteolytic cleavage product [Term] id: PR:000026175 name: vitamin K-dependent protein C isoform 1 def: "A vitamin K-dependent protein C that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04070-1 or a 1:1 ortholog thereof." [PRO:CNx] comment: Category=sequence. synonym: "PROC/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000013261 ! vitamin K-dependent protein C [Term] id: PR:000035918 name: vitamin K-dependent protein C activation peptide def: "A vitamin K-dependent protein C proteolytic cleavage product that corresponds to the dodecapeptide from the amino end of the heavy chain. Example: UniProtKB:P04070, 200-211." [PMID:2405901, PMID:468991, PMID:6589623, Reactome:R-HSA-141051] comment: Category=modification. synonym: "PROC/Clv:act_pep" EXACT PRO-short-label [PRO:DAN] is_a: PR:000021105 ! vitamin K-dependent protein C proteolytic cleavage product relationship: output_of GO:0016485 ! protein processing relationship: derives_from PR:000035920 ! vitamin K-dependent protein C heavy chain [Term] id: PR:000026177 name: pro-protein C light chain def: "A vitamin K-dependent protein C, signal peptide removed form that contains the N-terminal propeptide and the most N-terminal active polypeptide, and that is post-translationally modified to include multiple gamma-carboxyglutamic acid residues and one beta-hydroxyaspartic acid residue. Example: UniProtKB:P04070-1, 19-197, Glu-48/Glu-49/Glu-56/Glu-58/Glu-61/Glu-62/Glu-67/Glu-68/Glu-71, MOD:00041|Asp-113, MOD:00036." [PMID:2991887, PRO:CNx, PRO:DAN] comment: Category=modification. synonym: "PROC/Clv:proL" EXACT PRO-short-label [PRO:DAN] is_a: PR:000021104 ! vitamin K-dependent protein C, signal peptide removed form relationship: output_of GO:0016485 ! protein processing relationship: has_part MOD:00036 ! (2S,3R)-3-hydroxyaspartic acid relationship: has_part MOD:00041 ! L-gamma-carboxyglutamic acid [Term] id: PR:P04070-1 name: vitamin K-dependent protein C isoform 1 (human) def: "A vitamin K-dependent protein C isoform 1 that is encoded in the genome of human." [PRO:CNx] comment: Category=organism-sequence. synonym: "hPROC/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P04070-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000026175 ! vitamin K-dependent protein C isoform 1 [Term] id: PR:P33587 name: vitamin K-dependent protein C (mouse) def: "A vitamin K-dependent protein C that is encoded in the genome of mouse." [OMA:P33587, PRO:DNx] comment: Category=organism-gene. synonym: "Proc" RELATED Gene-based [UniProtKB:P33587] synonym: "mPROC" EXACT PRO-short-label [PRO:DNx] synonym: "autoprothrombin IIA (mouse)" EXACT [UniProtKB:P33587] synonym: "anticoagulant protein C (mouse)" EXACT [UniProtKB:P33587] synonym: "blood coagulation factor XIV (mouse)" EXACT [UniProtKB:P33587] xref: UniProtKB:P33587 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000013261 ! vitamin K-dependent protein C relationship: has_gene_template MGI:97771 ! Proc (mouse) [Term] id: PR:P04070-2 name: vitamin K-dependent protein C isoform h2 (human) def: "A vitamin K-dependent protein C (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P04070-2." [PRO:DNx, UniProtKB:P04070] comment: Category=organism-sequence. synonym: "hPROC/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P04070-2 is_a: PR:P04070 ! vitamin K-dependent protein C (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens