[Term] id: PR:000042226 name: Rap guanine nucleotide exchange factor 4 isoform 2 def: "A Rap guanine nucleotide exchange factor 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WZA2-2 or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=sequence. synonym: "RAPGEF4/iso:2" EXACT PRO-short-label [PRO:DNx] is_a: PR:000013729 ! Rap guanine nucleotide exchange factor 4 [Term] id: PR:000042225 name: Rap guanine nucleotide exchange factor 4 isoform 1 def: "A Rap guanine nucleotide exchange factor 4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WZA2-1 or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=sequence. synonym: "RAPGEF4/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000013729 ! Rap guanine nucleotide exchange factor 4 [Term] id: PR:000013729 name: Rap guanine nucleotide exchange factor 4 def: "A protein that is a translation product of the human RAPGEF4 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "CGEF2" RELATED Gene-based [] synonym: "EPAC2" RELATED Gene-based [] synonym: "EPAC 2" EXACT [] synonym: "RAPGEF4" EXACT PRO-short-label [PRO:DNx] synonym: "cAMP-GEFII" EXACT [] synonym: "exchange factor directly activated by cAMP 2" EXACT [] synonym: "exchange protein directly activated by cAMP 2" EXACT [] synonym: "cAMP-regulated guanine nucleotide exchange factor II" EXACT [] synonym: "cAMP-dependent Rap1 guanine-nucleotide exchange factor" EXACT [] xref: IUPHARobj:1293 is_a: PR:000000001 ! protein [Term] id: PR:Q9EQZ6-1 name: Rap guanine nucleotide exchange factor 4 isoform 1 (mouse) def: "A Rap guanine nucleotide exchange factor 4 isoform 1 that is encoded in the genome of mouse." [PRO:DNx] comment: Category=organism-sequence. synonym: "mRAPGEF4/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9EQZ6-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000042225 ! Rap guanine nucleotide exchange factor 4 isoform 1 [Term] id: PR:Q9EQZ6-2 name: Rap guanine nucleotide exchange factor 4 isoform 2 (mouse) def: "A Rap guanine nucleotide exchange factor 4 isoform 2 that is encoded in the genome of mouse." [PRO:DNx] comment: Category=organism-sequence. synonym: "mRAPGEF4/iso:2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9EQZ6-2 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000042226 ! Rap guanine nucleotide exchange factor 4 isoform 2 [Term] id: PR:Q9EQZ6-3 name: Rap guanine nucleotide exchange factor 4 isoform m3 (mouse) def: "A Rap guanine nucleotide exchange factor 4 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9EQZ6-3." [PRO:DNx, UniProtKB:Q9EQZ6] comment: Category=organism-sequence. synonym: "mRAPGEF4/iso:m3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9EQZ6-3 is_a: PR:Q9EQZ6 ! Rap guanine nucleotide exchange factor 4 (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:Q8WZA2-5 name: Rap guanine nucleotide exchange factor 4 isoform h5 (human) def: "A Rap guanine nucleotide exchange factor 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WZA2-5." [PRO:DNx, UniProtKB:Q8WZA2] comment: Category=organism-sequence. synonym: "hRAPGEF4/iso:h5" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q8WZA2-5 is_a: PR:Q8WZA2 ! Rap guanine nucleotide exchange factor 4 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q8WZA2-4 name: Rap guanine nucleotide exchange factor 4 isoform h4 (human) def: "A Rap guanine nucleotide exchange factor 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WZA2-4." [PRO:DNx, UniProtKB:Q8WZA2] comment: Category=organism-sequence. synonym: "hRAPGEF4/iso:h4" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q8WZA2-4 is_a: PR:Q8WZA2 ! Rap guanine nucleotide exchange factor 4 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q8WZA2 name: Rap guanine nucleotide exchange factor 4 (human) def: "A Rap guanine nucleotide exchange factor 4 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q8WZA2] comment: Category=organism-gene. synonym: "CGEF2" RELATED Gene-based [UniProtKB:Q8WZA2] synonym: "EPAC2" RELATED Gene-based [UniProtKB:Q8WZA2] synonym: "RAPGEF4" RELATED Gene-based [UniProtKB:Q8WZA2] synonym: "hRAPGEF4" EXACT PRO-short-label [PRO:DNx] synonym: "EPAC 2 (human)" EXACT [UniProtKB:Q8WZA2] synonym: "cAMP-GEFII (human)" EXACT [UniProtKB:Q8WZA2] synonym: "exchange factor directly activated by cAMP 2 (human)" EXACT [UniProtKB:Q8WZA2] synonym: "exchange protein directly activated by cAMP 2 (human)" EXACT [UniProtKB:Q8WZA2] synonym: "cAMP-regulated guanine nucleotide exchange factor II (human)" EXACT [UniProtKB:Q8WZA2] xref: Reactome:R-HSA-3008666 "PR:Q8WZA2 located_in GO:0005886" xref: UniProtKB:Q8WZA2 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000013729 ! Rap guanine nucleotide exchange factor 4 relationship: has_gene_template HGNC:16626 ! RAPGEF4 (human) [Term] id: PR:Q8WZA2-3 name: Rap guanine nucleotide exchange factor 4 isoform h3 (human) def: "A Rap guanine nucleotide exchange factor 4 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q8WZA2-3." [PRO:DNx, UniProtKB:Q8WZA2] comment: Category=organism-sequence. synonym: "hRAPGEF4/iso:h3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q8WZA2-3 is_a: PR:Q8WZA2 ! Rap guanine nucleotide exchange factor 4 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q8WZA2-2 name: Rap guanine nucleotide exchange factor 4 isoform 2 (human) def: "A Rap guanine nucleotide exchange factor 4 isoform 2 that is encoded in the genome of human." [PRO:DNx] comment: Category=organism-sequence. synonym: "hRAPGEF4/iso:2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q8WZA2-2 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000042226 ! Rap guanine nucleotide exchange factor 4 isoform 2 [Term] id: PR:Q8WZA2-1 name: Rap guanine nucleotide exchange factor 4 isoform 1 (human) def: "A Rap guanine nucleotide exchange factor 4 isoform 1 that is encoded in the genome of human." [PRO:DNx] comment: Category=organism-sequence. synonym: "hRAPGEF4/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q8WZA2-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000042225 ! Rap guanine nucleotide exchange factor 4 isoform 1 [Term] id: PR:Q9EQZ6 name: Rap guanine nucleotide exchange factor 4 (mouse) def: "A Rap guanine nucleotide exchange factor 4 that is encoded in the genome of mouse." [OMA:Q9EQZ6, PRO:DNx] comment: Category=organism-gene. synonym: "Cgef2" RELATED Gene-based [UniProtKB:Q9EQZ6] synonym: "Epac2" RELATED Gene-based [UniProtKB:Q9EQZ6] synonym: "Rapgef4" RELATED Gene-based [UniProtKB:Q9EQZ6] synonym: "mRAPGEF4" EXACT PRO-short-label [PRO:DNx] synonym: "EPAC 2 (mouse)" EXACT [UniProtKB:Q9EQZ6] synonym: "cAMP-GEFII (mouse)" EXACT [UniProtKB:Q9EQZ6] synonym: "exchange factor directly activated by cAMP 2 (mouse)" EXACT [UniProtKB:Q9EQZ6] synonym: "exchange protein directly activated by cAMP 2 (mouse)" EXACT [UniProtKB:Q9EQZ6] synonym: "cAMP-regulated guanine nucleotide exchange factor II (mouse)" EXACT [UniProtKB:Q9EQZ6] synonym: "cAMP-dependent Rap1 guanine-nucleotide exchange factor (mouse)" EXACT [UniProtKB:Q9EQZ6] xref: UniProtKB:Q9EQZ6 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000013729 ! Rap guanine nucleotide exchange factor 4 relationship: has_gene_template MGI:1917723 ! Rapgef4 (mouse)