[Term] id: PR:000049129 name: ribosomal protein S6 kinase alpha-3 phosphorylated 1 (human) def: "A ribosomal protein S6 kinase alpha-3 (human) that has been post-translationally modified to include phosphoserine at positions 227, 369, 386, and 737, and phosphothreonine at position 365, and 577 of the amino acid sequence represented by UniProtKB:P51812. UniProtKB:P51812, Ser-227/Ser-369/Ser-386/Ser-737, MOD:00046|Thr-365/Thr-577, MOD:00047." [PRO:DAN, Reactome:R-HSA-444286] comment: Category=organism-modification. Note: The modified sites indicated here (Ser-227/Ser-369/Ser-386/Ser-737/Thr-365/Thr-577) are referred to as Ser-222/Ser-364/Ser-381/Ser-733/Thr-360/Thr-574 in the literature using the rat Rps6ka1 sequence. [PRO:DAN, PMID:9430688] synonym: "hRPS6KA3/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P51812, Ser-227/Ser-369/Ser-386/Ser-737, MOD:00046|Thr-365/Thr-577, MOD:00047" EXACT PRO-proteoform-std [PRO:DAN] xref: Reactome:R-HSA-444286 "PR:000049129 located_in GO:0005654" is_a: PR:P51812 ! ribosomal protein S6 kinase alpha-3 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P51812 name: ribosomal protein S6 kinase alpha-3 (human) def: "A ribosomal protein S6 kinase alpha-3 that is encoded in the genome of human." [PRO:DNx, UniProtKB:P51812] comment: Category=organism-gene. synonym: "RSK2" RELATED Gene-based [UniProtKB:P51812] synonym: "ISPK1" RELATED Gene-based [UniProtKB:P51812] synonym: "RPS6KA3" RELATED Gene-based [UniProtKB:P51812] synonym: "hRPS6KA3" EXACT PRO-short-label [PRO:DNx] synonym: "MAPKAPK1B" RELATED Gene-based [UniProtKB:P51812] synonym: "RSK-2 (human)" EXACT [UniProtKB:P51812] synonym: "ISPK-1 (human)" EXACT [UniProtKB:P51812] synonym: "p90RSK3 (human)" EXACT [UniProtKB:P51812] synonym: "pp90RSK2 (human)" EXACT [UniProtKB:P51812] synonym: "p90-RSK 3 (human)" EXACT [UniProtKB:P51812] synonym: "MAPKAPK-1b (human)" EXACT [UniProtKB:P51812] synonym: "S6K-alpha-3 (human)" EXACT [UniProtKB:P51812] synonym: "MAPKAP kinase 1b (human)" EXACT [UniProtKB:P51812] synonym: "ribosomal S6 kinase 2 (human)" EXACT [UniProtKB:P51812] synonym: "MAPK-activated protein kinase 1b (human)" EXACT [UniProtKB:P51812] synonym: "insulin-stimulated protein kinase 1 (human)" EXACT [UniProtKB:P51812] synonym: "90 kDa ribosomal protein S6 kinase 3 (human)" EXACT [UniProtKB:P51812] synonym: "MAP kinase-activated protein kinase 1b (human)" EXACT [UniProtKB:P51812] xref: Reactome:R-HSA-199869 "PR:P51812 located_in GO:0005654" xref: Reactome:R-HSA-444250 "PR:P51812 located_in GO:0005829" xref: DTO:03100253 xref: UniProtKB:P51812 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000014284 ! ribosomal protein S6 kinase alpha-3 relationship: has_gene_template HGNC:10432 ! RPS6KA3 (human) [Term] id: PR:000014284 name: ribosomal protein S6 kinase alpha-3 def: "A ribosomal protein S6 kinase alpha that is a translation product of the human RPS6KA3 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "RSK2" RELATED Gene-based [] synonym: "ISPK1" RELATED Gene-based [] synonym: "RSK-2" EXACT [] synonym: "ISPK-1" EXACT [] synonym: "RPS6KA3" EXACT PRO-short-label [PRO:DNx] synonym: "p90RSK3" EXACT [] synonym: "pp90RSK2" EXACT [] synonym: "MAPKAPK1B" RELATED Gene-based [] synonym: "p90-RSK 3" EXACT [] synonym: "MAPKAPK-1b" EXACT [] synonym: "Rps6ka-rs1" RELATED Gene-based [] synonym: "S6K-alpha-3" EXACT [] synonym: "MAPKAP kinase 1b" EXACT [] synonym: "ribosomal S6 kinase 2" EXACT [] synonym: "MAPK-activated protein kinase 1b" EXACT [] synonym: "insulin-stimulated protein kinase 1" EXACT [] synonym: "90 kDa ribosomal protein S6 kinase 3" EXACT [] synonym: "MAP kinase-activated protein kinase 1b" EXACT [] xref: IUPHARobj:1528 is_a: PR:000029187 ! ribosomal protein S6 kinase alpha [Term] id: PR:P51812-1 name: ribosomal protein S6 kinase alpha-3 isoform 1 (human) def: "A ribosomal protein S6 kinase alpha-3 isoform 1 that is encoded in the genome of human." [PRO:DNx] comment: Category=organism-sequence. synonym: "hRPS6KA3/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P51812-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000039683 ! ribosomal protein S6 kinase alpha-3 isoform 1 [Term] id: PR:000049130 name: ribosomal protein S6 kinase alpha-3 phosphorylated 2 (human) def: "A ribosomal protein S6 kinase alpha-3 (human) that has been post-translationally modified to include phosphoserine at positions 227, 369, 386 and 715, and phosphothreonine at positions 231 and 365 of the amino acid sequence represented by UniProtKB:P51812. UniProtKB:P51812, Ser-227/Ser-369/Ser-386/Ser-715, MOD:00046|Thr-231/Thr-365, MOD:00047." [PRO:DNx, Reactome:R-HSA-199830] comment: Category=organism-modification. synonym: "hRPS6KA3/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P51812, Ser-227/Ser-369/Ser-386/Ser-715, MOD:00046|Thr-231/Thr-365, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-199830 "PR:000049130 located_in GO:0005654" is_a: PR:P51812 ! ribosomal protein S6 kinase alpha-3 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens