[Term]
id: PR:P79732
name: ribonucleoside-diphosphate reductase large subunit (zebrafish)
def: "A ribonucleoside-diphosphate reductase large subunit that is encoded in the genome of zebrafish." [PRO:DAN]
comment: Category=organism-gene.
synonym: "rrm1" RELATED Gene-based [UniProtKB:P79732]
synonym: "z-RRM1" EXACT PRO-short-label [PRO:DNx]
synonym: "ribonucleotide reductase large subunit (zebrafish)" EXACT [UniProtKB:P79732]
synonym: "ribonucleotide reductase protein R1 class I (zebrafish)" EXACT [UniProtKB:P79732]
synonym: "ribonucleoside-diphosphate reductase subunit M1 (zebrafish)" EXACT [UniProtKB:P79732]
xref: UniProtKB:P79732
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000014305 ! ribonucleoside-diphosphate reductase large subunit
relationship: has_gene_template ZFIN:ZDB-GENE-990415-247 ! rrm1 (zebrafish)

[Term]
id: PR:P23921
name: ribonucleoside-diphosphate reductase large subunit (human)
def: "A ribonucleoside-diphosphate reductase large subunit that is encoded in the genome of human." [PRO:DNx, UniProtKB:P23921]
comment: Category=organism-gene.
synonym: "RR1" RELATED Gene-based [UniProtKB:P23921]
synonym: "RRM1" RELATED Gene-based [UniProtKB:P23921]
synonym: "hRRM1" EXACT PRO-short-label [PRO:DNx]
synonym: "ribonucleotide reductase large subunit (human)" EXACT [UniProtKB:P23921]
synonym: "ribonucleoside-diphosphate reductase subunit M1 (human)" EXACT [UniProtKB:P23921]
xref: Reactome:R-HSA-73638 "PR:P23921 located_in GO:0005829"
xref: UniProtKB:P23921
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000014305 ! ribonucleoside-diphosphate reductase large subunit
relationship: has_gene_template HGNC:10451 ! RRM1 (human)

[Term]
id: PR:Q54Q71
name: ribonucleoside-diphosphate reductase large subunit (Dictyostelium discoideum)
def: "A ribonucleoside-diphosphate reductase large subunit that is encoded in the genome of Dictyostelium discoideum." [OMA:Q54Q71, PRO:DNx]
comment: Category=organism-gene.
synonym: "rnrA" RELATED Gene-based [UniProtKB:Q54Q71]
synonym: "Dicty-RRM1" EXACT PRO-short-label [PRO:DNx]
synonym: "DDB_G0284071" RELATED Gene-based [UniProtKB:Q54Q71]
synonym: "ribonucleotide reductase large subunit (Dictyostelium discoideum)" EXACT [UniProtKB:Q54Q71]
xref: UniProtKB:Q54Q71
intersection_of: only_in_taxon NCBITaxon:44689 ! Dictyostelium discoideum
intersection_of: PR:000014305 ! ribonucleoside-diphosphate reductase large subunit
relationship: has_gene_template dictyBase:DDB_G0284071 ! rnrA (Dictyostelium discoideum)

[Term]
id: PR:Q03604
name: ribonucleoside-diphosphate reductase large subunit (worm)
def: "A ribonucleoside-diphosphate reductase large subunit that is encoded in the genome of worm." [OMA:Q03604, PRO:DNx]
comment: Category=organism-gene.
synonym: "rnr-1" RELATED Gene-based [UniProtKB:Q03604]
synonym: "T23G5.1" RELATED Gene-based [UniProtKB:Q03604]
synonym: "RRM1 (worm)" EXACT PRO-short-label [PRO:DNx]
synonym: "ribonucleotide reductase large subunit (worm)" EXACT [UniProtKB:Q03604]
xref: UniProtKB:Q03604
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000014305 ! ribonucleoside-diphosphate reductase large subunit
relationship: has_gene_template WormBase:WBGene00004391 ! rnr-1 (worm)

[Term]
id: PR:P9WH75
name: ribonucleoside-diphosphate reductase subunit alpha (Mycobacterium tuberculosis H37Rv)
def: "A ribonucleoside-diphosphate reductase large subunit that is encoded in the genome of Mycobacterium tuberculosis H37Rv." [OMA:P9WH75, PRO:DNx]
comment: Category=organism-gene. Requested by=PubChem.
synonym: "nrdE" RELATED Gene-based [UniProtKB:P9WH75]
synonym: "Rv3051c" RELATED Gene-based [UniProtKB:P9WH75]
synonym: "MTV012.66c" RELATED Gene-based [UniProtKB:P9WH75]
synonym: "RRM1 (MYCTU)" EXACT PRO-short-label [PRO:DNx]
synonym: "ribonucleotide reductase R1 subunit (Mycobacterium tuberculosis H37Rv)" EXACT [UniProtKB:P9WH75]
xref: UniProtKB:P9WH75
intersection_of: only_in_taxon NCBITaxon:83332 ! Mycobacterium tuberculosis H37Rv
intersection_of: PR:000014305 ! ribonucleoside-diphosphate reductase large subunit
relationship: has_gene_template NCBIGene:888869 ! nrdE (Mycobacterium tuberculosis H37Rv)

[Term]
id: PR:000036298
name: ribonucleoside-diphosphate reductase large chain (Schizosaccharomyces pombe)
def: "A ribonucleoside-diphosphate reductase large subunit that is encoded in the genome of Schizosaccharomyces pombe." [PRO:DAN]
comment: Category=organism-gene. Requested by=PomBase.
synonym: "Spom-cdc22" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe
intersection_of: PR:000014305 ! ribonucleoside-diphosphate reductase large subunit
relationship: has_gene_template PomBase:SPAC1F7.05 ! cdc22 (Schizosaccharomyces pombe)

[Term]
id: PR:P07742
name: ribonucleoside-diphosphate reductase large subunit (mouse)
def: "A ribonucleoside-diphosphate reductase large subunit that is encoded in the genome of mouse." [OMA:P07742, PRO:DNx]
comment: Category=organism-gene.
synonym: "Rrm1" RELATED Gene-based [UniProtKB:P07742]
synonym: "mRRM1" EXACT PRO-short-label [PRO:DNx]
synonym: "ribonucleotide reductase large subunit (mouse)" EXACT [UniProtKB:P07742]
synonym: "ribonucleoside-diphosphate reductase subunit M1 (mouse)" EXACT [UniProtKB:P07742]
xref: UniProtKB:P07742
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000014305 ! ribonucleoside-diphosphate reductase large subunit
relationship: has_gene_template MGI:98180 ! Rrm1 (mouse)

[Term]
id: PR:Q9SJ20
name: ribonucleoside-diphosphate reductase large subunit (Arabidopsis thaliana)
def: "A ribonucleoside-diphosphate reductase large subunit that is encoded in the genome of Arabidopsis thaliana." [OMA:Q9SJ20, PRO:DNx]
comment: Category=organism-gene.
synonym: "DPD2" RELATED Gene-based [UniProtKB:Q9SJ20]
synonym: "RNR1" RELATED Gene-based [UniProtKB:Q9SJ20]
synonym: "AtRNR1" EXACT [UniProtKB:Q9SJ20]
synonym: "At-RRM1" EXACT PRO-short-label [PRO:DNx]
synonym: "F7D8.11" RELATED Gene-based [UniProtKB:Q9SJ20]
synonym: "At2g21790" RELATED Gene-based [UniProtKB:Q9SJ20]
synonym: "protein DEFECTIVE IN POLLEN DNA DEGRADATION 2 (Arabidopsis thaliana)" EXACT [UniProtKB:Q9SJ20]
synonym: "ribonucleoside-diphosphate reductase R1 subunit (Arabidopsis thaliana)" EXACT [UniProtKB:Q9SJ20]
xref: UniProtKB:Q9SJ20
intersection_of: only_in_taxon NCBITaxon:3702 ! Arabidopsis thaliana
intersection_of: PR:000014305 ! ribonucleoside-diphosphate reductase large subunit
relationship: has_gene_template Araport:AT2G21790 ! RNR1 (Arabidopsis thaliana)

[Term]
id: PR:P07742-1
name: ribonucleoside-diphosphate reductase large subunit isoform 1 (mouse)
def: "A ribonucleoside-diphosphate reductase large subunit isoform 1 that is encoded in the genome of mouse." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "mRRM1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P07742-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000039107 ! ribonucleoside-diphosphate reductase large subunit isoform 1

[Term]
id: PR:000039107
name: ribonucleoside-diphosphate reductase large subunit isoform 1
def: "A ribonucleoside-diphosphate reductase large subunit that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P23921-1 or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=sequence.
synonym: "RRM1/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000014305 ! ribonucleoside-diphosphate reductase large subunit

[Term]
id: PR:P36602
name: ribonucleoside-diphosphate reductase large chain (Schizosaccharomyces pombe 972h-)
def: "A ribonucleoside-diphosphate reductase large subunit that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:P36602, PMID:14648198, PRO:CNA]
comment: Category=organism-gene.
synonym: "cdc22" RELATED Gene-based [UniProtKB:P36602]
synonym: "SPAC1F7.05" RELATED Gene-based [UniProtKB:P36602]
synonym: "Spom972h-cdc22" EXACT PRO-short-label [PRO:DNx]
synonym: "ribonucleotide reductase (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:P36602]
xref: UniProtKB:P36602
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000014305 ! ribonucleoside-diphosphate reductase large subunit
relationship: has_gene_template PomBase:SPAC1F7.05 ! cdc22 (Schizosaccharomyces pombe)

[Term]
id: PR:P23921-1
name: ribonucleoside-diphosphate reductase large subunit isoform 1 (human)
def: "A ribonucleoside-diphosphate reductase large subunit isoform 1 that is encoded in the genome of human." [PRO:DNx]
comment: Category=organism-sequence.
synonym: "hRRM1/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P23921-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000039107 ! ribonucleoside-diphosphate reductase large subunit isoform 1

[Term]
id: PR:P48591
name: ribonucleoside-diphosphate reductase large subunit (fruit fly)
def: "A ribonucleoside-diphosphate reductase large subunit that is encoded in the genome of fruit fly." [OMA:P48591, PRO:DNx]
comment: Category=organism-gene.
synonym: "RnrL" RELATED Gene-based [UniProtKB:P48591]
synonym: "CG5371" RELATED Gene-based [UniProtKB:P48591]
synonym: "fly-RRM1" EXACT PRO-short-label [PRO:DNx]
synonym: "ribonucleotide reductase large subunit (fruit fly)" EXACT [UniProtKB:P48591]
synonym: "ribonucleoside-diphosphate reductase subunit M1 (fruit fly)" EXACT [UniProtKB:P48591]
xref: UniProtKB:P48591
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000014305 ! ribonucleoside-diphosphate reductase large subunit
relationship: has_gene_template FlyBase:FBgn0011703 ! RnrL (fruit fly)

[Term]
id: PR:000014305
name: ribonucleoside-diphosphate reductase large subunit
def: "A protein that is a translation product of the human RRM1 gene or a 1:1 ortholog thereof." [PRO:DAN]
comment: Category=gene. Note: The fission yeast ortholog is called cdc22. [PRO:CNA, PMID:14648198]
synonym: "RR1" RELATED Gene-based []
synonym: "RRM1" EXACT PRO-short-label [PRO:DNx]
synonym: "ribonucleotide reductase large subunit" EXACT []
synonym: "ribonucleoside-diphosphate reductase subunit M1" EXACT []
xref: IUPHARobj:2630
is_a: PR:000000001 ! protein