[Term]
id: PR:000014527
name: amiloride-sensitive sodium channel subunit alpha
def: "An epithelial sodium channel protein that is a translation product of the human SCNN1A gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "ENaCA" EXACT []
synonym: "SCNEA" EXACT []
synonym: "SCNN1" RELATED Gene-based []
synonym: "SCNN1A" EXACT PRO-short-label [PRO:DNx]
synonym: "alpha-ENaC" EXACT []
synonym: "alpha-NaCH" EXACT []
synonym: "epithelial Na(+) channel subunit alpha" EXACT []
synonym: "nonvoltage-gated sodium channel 1 subunit alpha" EXACT []
xref: IUPHARobj:738
is_a: PR:000044663 ! epithelial sodium channel protein

[Term]
id: PR:P37088
name: amiloride-sensitive sodium channel subunit alpha (human)
def: "An amiloride-sensitive sodium channel subunit alpha that is encoded in the genome of human." [PRO:DNx, UniProtKB:P37088]
comment: Category=organism-gene.
synonym: "SCNN1" RELATED Gene-based [UniProtKB:P37088]
synonym: "SCNN1A" RELATED Gene-based [UniProtKB:P37088]
synonym: "hSCNN1A" EXACT PRO-short-label [PRO:DNx]
synonym: "ENaCA (human)" EXACT [UniProtKB:P37088]
synonym: "SCNEA (human)" EXACT [UniProtKB:P37088]
synonym: "alpha-ENaC (human)" EXACT [UniProtKB:P37088]
synonym: "alpha-NaCH (human)" EXACT [UniProtKB:P37088]
synonym: "epithelial Na(+) channel subunit alpha (human)" EXACT [UniProtKB:P37088]
synonym: "nonvoltage-gated sodium channel 1 subunit alpha (human)" EXACT [UniProtKB:P37088]
xref: Reactome:R-HSA-2671922 "PR:P37088 located_in GO:0005886"
xref: DTO:01100303
xref: UniProtKB:P37088
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000014527 ! amiloride-sensitive sodium channel subunit alpha
relationship: has_gene_template HGNC:10599 ! SCNN1A (human)

[Term]
id: PR:P37088-6
name: amiloride-sensitive sodium channel subunit alpha isoform h6 (human)
def: "An amiloride-sensitive sodium channel subunit alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P37088-6." [PRO:DNx, UniProtKB:P37088]
comment: Category=organism-sequence.
synonym: "hSCNN1A/iso:h6" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P37088-6
is_a: PR:P37088 ! amiloride-sensitive sodium channel subunit alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P37088-4
name: amiloride-sensitive sodium channel subunit alpha isoform h4 (human)
def: "An amiloride-sensitive sodium channel subunit alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P37088-4." [PRO:DNx, UniProtKB:P37088]
comment: Category=organism-sequence.
synonym: "hSCNN1A/iso:h4" EXACT PRO-short-label [PRO:DNx]
synonym: "amiloride-sensitive sodium channel subunit alpha isoform Alpha ENAC-19 (human)" EXACT [UniProtKB:P37088]
xref: UniProtKB:P37088-4
is_a: PR:P37088 ! amiloride-sensitive sodium channel subunit alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P37088-5
name: amiloride-sensitive sodium channel subunit alpha isoform h5 (human)
def: "An amiloride-sensitive sodium channel subunit alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P37088-5." [PRO:DNx, UniProtKB:P37088]
comment: Category=organism-sequence.
synonym: "hSCNN1A/iso:h5" EXACT PRO-short-label [PRO:DNx]
synonym: "amiloride-sensitive sodium channel subunit alpha isoform Alpha ENAC+22 (human)" EXACT [UniProtKB:P37088]
xref: UniProtKB:P37088-5
is_a: PR:P37088 ! amiloride-sensitive sodium channel subunit alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P37088-2
name: amiloride-sensitive sodium channel subunit alpha isoform h2 (human)
def: "An amiloride-sensitive sodium channel subunit alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P37088-2." [PRO:DNx, UniProtKB:P37088]
comment: Category=organism-sequence.
synonym: "hSCNN1A/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "amiloride-sensitive sodium channel subunit alpha isoform Alpha ENAC2 (human)" EXACT [UniProtKB:P37088]
xref: UniProtKB:P37088-2
is_a: PR:P37088 ! amiloride-sensitive sodium channel subunit alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P37088-3
name: amiloride-sensitive sodium channel subunit alpha isoform h3 (human)
def: "An amiloride-sensitive sodium channel subunit alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P37088-3." [PRO:DNx, UniProtKB:P37088]
comment: Category=organism-sequence.
synonym: "hSCNN1A/iso:h3" EXACT PRO-short-label [PRO:DNx]
synonym: "amiloride-sensitive sodium channel subunit alpha isoform Alpha ENACx (human)" EXACT [UniProtKB:P37088]
xref: UniProtKB:P37088-3
is_a: PR:P37088 ! amiloride-sensitive sodium channel subunit alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:P37088-1
name: amiloride-sensitive sodium channel subunit alpha isoform h1 (human)
def: "An amiloride-sensitive sodium channel subunit alpha (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P37088-1." [PRO:DNx, UniProtKB:P37088]
comment: Category=organism-sequence.
synonym: "hSCNN1A/iso:h1" EXACT PRO-short-label [PRO:DNx]
synonym: "amiloride-sensitive sodium channel subunit alpha isoform Alpha ENAC1 (human)" EXACT [UniProtKB:P37088]
xref: UniProtKB:P37088-1
is_a: PR:P37088 ! amiloride-sensitive sodium channel subunit alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000049168
name: amiloride-sensitive sodium channel subunit alpha ubiquitinated form (human)
def: "An amiloride-sensitive sodium channel subunit alpha (human) that includes at least one ubiquitinated lysine. UniProtKB:P37088, MOD:01148." [PRO:DNx, Reactome:R-HSA-2684930]
comment: Category=organism-modification.
synonym: "hSCNN1A/UbiqLys+" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P37088, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-2684930 "PR:000049168 located_in GO:0005886"
intersection_of: has_part MOD:01148 ! ubiquitinylated lysine
intersection_of: PR:P37088 ! amiloride-sensitive sodium channel subunit alpha (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens