[Term] id: PR:000049204 name: alpha-1-antitrypsin, signal peptide removed form (human) def: "An alpha-1-antitrypsin (human) that has had the signal peptide removed. UniProtKB:P01009, 25-418." [PRO:DNx, Reactome:R-HSA-141755, Reactome:R-HSA-141757] comment: Category=organism-modification. synonym: "PRO_0000032377" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hSERPINA1/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P01009, 25-418" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-141755 "PR:000049204 located_in GO:0031093" xref: Reactome:R-HSA-141757 "PR:000049204 located_in GO:0005576" xref: Reactome:R-HSA-6804783 "PR:000049204 located_in GO:1904813" xref: Reactome:R-HSA-8956709 "PR:000049204 located_in GO:0005788" intersection_of: PR:P01009 ! alpha-1-antitrypsin (human) intersection_of: lacks_part SO:0000418 ! signal_peptide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000014678 name: alpha-1-antitrypsin def: "A serpin that is a translation product of the human SERPINA1 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "PI" RELATED Gene-based [] synonym: "AAT" RELATED Gene-based [] synonym: "PRO0684" RELATED Gene-based [] synonym: "PRO2209" RELATED Gene-based [] synonym: "SERPINA1" EXACT PRO-short-label [PRO:DNx] synonym: "serpin A1" EXACT [] synonym: "alpha-1-antiproteinase" BROAD [PRO:DNx] synonym: "alpha-1 protease inhibitor" EXACT [] is_a: PR:000025875 ! serpin [Term] id: PR:P01009 name: alpha-1-antitrypsin (human) def: "An alpha-1-antitrypsin that is encoded in the genome of human." [PRO:CNA, UniProtKB:P01009] comment: Category=organism-gene. synonym: "PI" RELATED Gene-based [UniProtKB:P01009] synonym: "AAT" RELATED Gene-based [UniProtKB:P01009] synonym: "PRO0684" RELATED Gene-based [UniProtKB:P01009] synonym: "PRO2209" RELATED Gene-based [UniProtKB:P01009] synonym: "SERPINA1" RELATED Gene-based [UniProtKB:P01009] synonym: "hSERPINA1" EXACT PRO-short-label [PRO:DNx] synonym: "serpin A1 (human)" EXACT [UniProtKB:P01009] synonym: "alpha-1-antiproteinase (human)" EXACT [UniProtKB:P01009] synonym: "alpha-1 protease inhibitor (human)" EXACT [UniProtKB:P01009] xref: UniProtKB:P01009 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000014678 ! alpha-1-antitrypsin relationship: has_gene_template HGNC:8941 ! SERPINA1 (human) [Term] id: PR:P01009-2 name: alpha-1-antitrypsin isoform h2 (human) def: "An alpha-1-antitrypsin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01009-2." [PRO:DNx, UniProtKB:P01009] comment: Category=organism-sequence. synonym: "hSERPINA1/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P01009-2 is_a: PR:P01009 ! alpha-1-antitrypsin (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P01009-3 name: alpha-1-antitrypsin isoform h3 (human) def: "An alpha-1-antitrypsin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01009-3." [PRO:DNx, UniProtKB:P01009] comment: Category=organism-sequence. synonym: "hSERPINA1/iso:h3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P01009-3 is_a: PR:P01009 ! alpha-1-antitrypsin (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P01009-1 name: alpha-1-antitrypsin isoform h1 (human) def: "An alpha-1-antitrypsin (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01009-1." [PRO:DNx, UniProtKB:P01009] comment: Category=organism-sequence. synonym: "hSERPINA1/iso:h1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P01009-1 is_a: PR:P01009 ! alpha-1-antitrypsin (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens