[Term] id: PR:Q96EB6 name: NAD-dependent protein deacetylase sirtuin-1 (human) def: "An NAD-dependent protein deacetylase sirtuin-1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q96EB6] comment: Category=organism-gene. synonym: "SIRT1" RELATED Gene-based [UniProtKB:Q96EB6] synonym: "hSIR2" EXACT [UniProtKB:Q96EB6] synonym: "SIR2L1" RELATED Gene-based [UniProtKB:Q96EB6] synonym: "hSIRT1" EXACT PRO-short-label [PRO:DNx] synonym: "SIR2-like protein 1 (human)" EXACT [UniProtKB:Q96EB6] synonym: "regulatory protein SIR2 homolog 1 (human)" EXACT [UniProtKB:Q96EB6] synonym: "NAD-dependent protein deacylase sirtuin-1 (human)" EXACT [UniProtKB:Q96EB6] xref: UniProtKB:Q96EB6 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000014888 ! NAD-dependent protein deacetylase sirtuin-1 relationship: has_gene_template HGNC:14929 ! SIRT1 (human) [Term] id: PR:Q96EB6-2 name: NAD-dependent protein deacetylase sirtuin-1 isoform h2 (human) def: "An NAD-dependent protein deacetylase sirtuin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96EB6-2." [PRO:DNx, UniProtKB:Q96EB6] comment: Category=organism-sequence. synonym: "hSIRT1/iso:h2" EXACT PRO-short-label [PRO:DNx] synonym: "NAD-dependent protein deacetylase sirtuin-1 isoform delta-exon8 (human)" EXACT [UniProtKB:Q96EB6] xref: UniProtKB:Q96EB6-2 is_a: PR:Q96EB6 ! NAD-dependent protein deacetylase sirtuin-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049252 name: NAD-dependent protein deacetylase sirtuin-1, initiator methionine removed form (human) def: "An NAD-dependent protein deacetylase sirtuin-1 (human) that has had the initiator methionine removed. UniProtKB:Q96EB6, 2-747." [PRO:DNx, Reactome:R-HSA-427531] comment: Category=organism-modification. synonym: "PRO_0000110256" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hSIRT1/InitMet-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q96EB6, 2-747" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-427531 "PR:000049252 located_in GO:0005654" intersection_of: lacks_part PR:000021937 ! initiator methionine intersection_of: PR:Q96EB6 ! NAD-dependent protein deacetylase sirtuin-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000014888 name: NAD-dependent protein deacetylase sirtuin-1 def: "A protein that is a translation product of the human SIRT1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "sir2" EXACT [] synonym: "SIR2a" EXACT [] synonym: "SIRT1" EXACT PRO-short-label [PRO:DNx] synonym: "SIR2L1" RELATED Gene-based [] synonym: "SIR2alpha" EXACT [] synonym: "SIR2-like protein 1" EXACT [] synonym: "regulatory protein SIR2 homolog 1" EXACT [] synonym: "NAD-dependent deacetylase sirtuin-1" EXACT [] synonym: "NAD-dependent protein deacylase sirtuin-1" EXACT [] xref: IUPHARobj:2707 is_a: PR:000000001 ! protein [Term] id: PR:Q96EB6-1 name: NAD-dependent protein deacetylase sirtuin-1 isoform h1 (human) def: "An NAD-dependent protein deacetylase sirtuin-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q96EB6-1." [PRO:DNx, UniProtKB:Q96EB6] comment: Category=organism-sequence. synonym: "hSIRT1/iso:h1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q96EB6-1 is_a: PR:Q96EB6 ! NAD-dependent protein deacetylase sirtuin-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens