[Term]
id: PR:000015288
name: smoothened
def: "A frizzled-like G-protein coupled receptor that is a translation product of the human SMO gene or a 1:1 ortholog thereof." [PRO:DAN]
comment: Category=gene.
synonym: "SMO" EXACT PRO-short-label [PRO:DNx]
synonym: "SMOH" RELATED Gene-based []
synonym: "protein Gx" EXACT []
xref: IUPHARobj:239
is_a: PR:000001315 ! frizzled-like G-protein coupled receptor

[Term]
id: PR:000049298
name: smoothened homolog, signal peptide removed phosphorylated 1 (human)
def: "A smoothened homolog (human) that has had the signal peptide removed and has been post-translationally modified to include phosphoserine at positions 588, 590 and 595, and phosphothreonine at position 593 of the amino acid sequence represented by UniProtKB:Q99835. UniProtKB:Q99835, 28-787, Ser-588/Ser-590/Ser-595, MOD:00046|Thr-593, MOD:00047." [PRO:DNx, Reactome:R-HSA-5632525]
comment: Category=organism-modification.
synonym: "hSMO/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000013015, Ser-588/Ser-590/Ser-595, MOD:00046|Thr-593, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q99835, 28-787, Ser-588/Ser-590/Ser-595, MOD:00046|Thr-593, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5632525 "PR:000049298 located_in GO:0060170"
is_a: PR:Q99835 ! smoothened homolog (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000049299
name: smoothened homolog, signal peptide removed phosphorylated 2 (human)
def: "A smoothened homolog (human) that has had the signal peptide removed and has been post-translationally modified to include phosphoserine at positions 588, 590, 595, 611, 615 and 616, and phosphothreonine at position 593 of the amino acid sequence represented by UniProtKB:Q99835. UniProtKB:Q99835, 28-787, Ser-588/Ser-590/Ser-595/Ser-611/Ser-615/Ser-616, MOD:00046|Thr-593, MOD:00047." [PRO:DNx, Reactome:R-HSA-5632528]
comment: Category=organism-modification.
synonym: "hSMO/SigPep-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000013015, Ser-588/Ser-590/Ser-595/Ser-611/Ser-615/Ser-616, MOD:00046|Thr-593, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q99835, 28-787, Ser-588/Ser-590/Ser-595/Ser-611/Ser-615/Ser-616, MOD:00046|Thr-593, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-5632528 "PR:000049299 located_in GO:0060170"
is_a: PR:Q99835 ! smoothened homolog (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:Q99835
name: smoothened homolog (human)
def: "A smoothened that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q99835]
comment: Category=organism-gene.
synonym: "SMO" RELATED Gene-based [UniProtKB:Q99835]
synonym: "SMOH" RELATED Gene-based [UniProtKB:Q99835]
synonym: "hSMO" EXACT PRO-short-label [PRO:DNx]
synonym: "protein Gx (human)" EXACT [UniProtKB:Q99835]
xref: DTO:02100769
xref: UniProtKB:Q99835
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000015288 ! smoothened
relationship: has_gene_template HGNC:11119 ! SMO (human)

[Term]
id: PR:000049297
name: smoothened homolog, signal peptide removed form (human)
def: "A smoothened homolog (human) that has had the signal peptide removed. UniProtKB:Q99835, 28-787." [PRO:DNx, Reactome:R-HSA-445121, Reactome:R-HSA-5610419, Reactome:R-HSA-5610422, Reactome:R-HSA-5624094]
comment: Category=organism-modification.
synonym: "hSMO/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000013015" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q99835, 28-787" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-445121 "PR:000049297 located_in GO:0005886"
xref: Reactome:R-HSA-5610419 "PR:000049297 located_in GO:0097542"
xref: Reactome:R-HSA-5610422 "PR:000049297 located_in GO:0030666"
xref: Reactome:R-HSA-5624094 "PR:000049297 located_in GO:0060170"
intersection_of: PR:Q99835 ! smoothened homolog (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens