[Term]
id: PR:O62183
name: F23B2.6 (worm)
def: "A THO complex subunit 4 that is encoded in the genome of worm." [OMA:O62183, PRO:DNx]
comment: Category=organism-gene.
synonym: "CELE_F23B2.6" RELATED Gene-based [UniProtKB:O62183]
synonym: "ALYREF (worm)" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O62183
intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans
intersection_of: PR:000016313 ! THO complex subunit 4
relationship: has_gene_template WormBase:WBGene00000121 ! aly-2 (worm)

[Term]
id: PR:O08583
name: THO complex subunit 4 (mouse)
def: "A THO complex subunit 4 that is encoded in the genome of mouse." [OMA:O08583, PRO:DNx]
comment: Category=organism-gene.
synonym: "Aly" RELATED Gene-based [UniProtKB:O08583]
synonym: "Ref1" RELATED Gene-based [UniProtKB:O08583]
synonym: "THOC4" RELATED Gene-based [UniProtKB:O08583]
synonym: "Alyref" RELATED Gene-based [UniProtKB:O08583]
synonym: "Refbp1" RELATED Gene-based [UniProtKB:O08583]
synonym: "mALYREF" EXACT PRO-short-label [PRO:DNx]
synonym: "Tho4 (mouse)" EXACT [UniProtKB:O08583]
synonym: "REF1-I (mouse)" EXACT [UniProtKB:O08583]
synonym: "Aly/REF export factor (mouse)" EXACT [UniProtKB:O08583]
synonym: "Ally of AML-1 and LEF-1 (mouse)" EXACT [UniProtKB:O08583]
synonym: "transcriptional coactivator Aly/REF (mouse)" EXACT [UniProtKB:O08583]
synonym: "RNA and export factor-binding protein 1 (mouse)" EXACT [UniProtKB:O08583]
xref: UniProtKB:O08583
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000016313 ! THO complex subunit 4
relationship: has_gene_template MGI:1341044 ! Alyref (mouse)

[Term]
id: PR:Q86V81
name: THO complex subunit 4 (human)
def: "A THO complex subunit 4 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q86V81]
comment: Category=organism-gene.
synonym: "ALY" RELATED Gene-based [UniProtKB:Q86V81]
synonym: "BEF" RELATED Gene-based [UniProtKB:Q86V81]
synonym: "THOC4" RELATED Gene-based [UniProtKB:Q86V81]
synonym: "ALYREF" RELATED Gene-based [UniProtKB:Q86V81]
synonym: "hALYREF" EXACT PRO-short-label [PRO:DNx]
synonym: "Tho4 (human)" EXACT [UniProtKB:Q86V81]
synonym: "Aly/REF export factor (human)" EXACT [UniProtKB:Q86V81]
synonym: "Ally of AML-1 and LEF-1 (human)" EXACT [UniProtKB:Q86V81]
synonym: "bZIP-enhancing factor BEF (human)" EXACT [UniProtKB:Q86V81]
synonym: "transcriptional coactivator Aly/REF (human)" EXACT [UniProtKB:Q86V81]
xref: UniProtKB:Q86V81
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000016313 ! THO complex subunit 4
relationship: has_gene_template HGNC:19071 ! ALYREF (human)

[Term]
id: PR:Q9V3E7
name: LD24793p (fruit fly)
def: "A THO complex subunit 4 that is encoded in the genome of fruit fly." [OMA:Q9V3E7, PRO:DNx]
comment: Category=organism-gene.
synonym: "Aly" RELATED Gene-based [UniProtKB:Q9V3E7]
synonym: "CG1101" RELATED Gene-based [UniProtKB:Q9V3E7]
synonym: "fly-ALYREF" EXACT PRO-short-label [PRO:DNx]
synonym: "RNA and export factor binding protein 1 (fruit fly)" EXACT [UniProtKB:Q9V3E7]
xref: UniProtKB:Q9V3E7
intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster
intersection_of: PR:000016313 ! THO complex subunit 4
relationship: has_gene_template FlyBase:FBgn0010774 ! Ref1 (fruit fly)

[Term]
id: PR:Q09330
name: mRNA export protein mlo3 (Schizosaccharomyces pombe 972h-)
def: "A THO complex subunit 4 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [OMA:Q09330, PRO:DNx]
comment: Category=organism-gene.
synonym: "mlo3" RELATED Gene-based [UniProtKB:Q09330]
synonym: "SPBC1D7.04" RELATED Gene-based [UniProtKB:Q09330]
synonym: "Spom972h-ALYREF" EXACT PRO-short-label [PRO:DNx]
synonym: "RNA-annealing protein mlo3 (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:Q09330]
xref: UniProtKB:Q09330
intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h-
intersection_of: PR:000016313 ! THO complex subunit 4
relationship: has_gene_template PomBase:SPBC1D7.04 ! mlo3 (Schizosaccharomyces pombe)

[Term]
id: PR:000016313
name: THO complex subunit 4
def: "A protein that is a translation product of the human ALYREF gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "ALY" RELATED Gene-based []
synonym: "BEF" RELATED Gene-based []
synonym: "Ref1" RELATED Gene-based []
synonym: "tho4" EXACT []
synonym: "THOC4" RELATED Gene-based []
synonym: "ALYREF" EXACT PRO-short-label [PRO:DNx]
synonym: "REF1-I" EXACT []
synonym: "Refbp1" RELATED Gene-based []
synonym: "Aly/REF export factor" EXACT []
synonym: "Ally of AML-1 and LEF-1" EXACT []
synonym: "bZIP-enhancing factor BEF" EXACT []
synonym: "transcriptional coactivator Aly/REF" EXACT []
synonym: "RNA and export factor-binding protein 1" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:000046327
name: THO complex subunit 4, initiator methionine removed form (human)
def: "A THO complex subunit 4 (human) that has had the initiator methionine removed. UniProtKB:Q86V81, 2-257." [PRO:DNx, Reactome:R-HSA-156649, Reactome:R-HSA-158482]
comment: Category=organism-modification.
synonym: "PRO_0000081974" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hALYREF/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q86V81, 2-257" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-156649 "PR:000046327 located_in GO:0005654"
xref: Reactome:R-HSA-158482 "PR:000046327 located_in GO:0005829"
xref: TDR:4300
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:Q86V81 ! THO complex subunit 4 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O08583-2
name: THO complex subunit 4 isoform m2 (mouse)
def: "A THO complex subunit 4 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O08583-2." [PRO:DNx, UniProtKB:O08583]
comment: Category=organism-sequence.
synonym: "mALYREF/iso:m2" EXACT PRO-short-label [PRO:DNx]
synonym: "THO complex subunit 4 isoform Refbp1-II (mouse)" EXACT [UniProtKB:O08583]
xref: UniProtKB:O08583-2
is_a: PR:O08583 ! THO complex subunit 4 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:O08583-1
name: THO complex subunit 4 isoform m1 (mouse)
def: "A THO complex subunit 4 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O08583-1." [PRO:DNx, UniProtKB:O08583]
comment: Category=organism-sequence.
synonym: "mALYREF/iso:m1" EXACT PRO-short-label [PRO:DNx]
synonym: "THO complex subunit 4 isoform Refbp1-I (mouse)" EXACT [UniProtKB:O08583]
xref: UniProtKB:O08583-1
is_a: PR:O08583 ! THO complex subunit 4 (mouse)
relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus

[Term]
id: PR:000021663
name: THO complex subunit 4, initiator methionine removed form
def: "A THO complex subunit 4 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "THOC4/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000016313 ! THO complex subunit 4
intersection_of: lacks_part PR:000021937 ! initiator methionine