[Term] id: PR:000049527 name: TP53-binding protein 1 phosphorylated 2 (human) def: "A TP53-binding protein 1 (human) that has been post-translationally modified to include phosphoserine at positions 25 and 1778 of the amino acid sequence represented by UniProtKB:Q12888. UniProtKB:Q12888, Ser-25/Ser-1778, MOD:00046." [PRO:DNx, Reactome:R-HSA-5683418] comment: Category=organism-modification. synonym: "hTP53BP1/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q12888, Ser-25/Ser-1778, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-5683418 "PR:000049527 located_in GO:0005654" is_a: PR:Q12888 ! TP53-binding protein 1 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000037503 name: DNA repair protein crb2 phosphorylated 2 (Schizosaccharomyces pombe) def: "A DNA repair protein crb2 (Schizosaccharomyces pombe) that is phosphorylated at two conserved SQ/TQ motifs in the N-terminal region. Example: UniProtKB:P87074, Thr-73, MOD:00047|Ser-80, MOD:00046." [PMID:22792081, PomBase:MAH] comment: Category=organism-modification. Requested by=PomBase. synonym: "Spom-rhp9/Phos:2" EXACT PRO-short-label [PRO:DAN] synonym: "Crb2 phosphorylated" RELATED [] synonym: "UniProtKB:P87074, Thr-73, MOD:00047|Ser-80, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx] synonym: "DNA repair protein rhp9 phosphorylated 2 (Schizosaccharomyces pombe)" RELATED [PomBase:MAH] is_a: PR:000029999 ! DNA repair protein crb2 (Schizosaccharomyces pombe) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: has_part MOD:00696 ! phosphorylated residue relationship: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe [Term] id: PR:000029999 name: DNA repair protein crb2 (Schizosaccharomyces pombe) def: "A TP53-binding protein 1 that is encoded in the genome of Schizosaccharomyces pombe." [PRO:DAN] comment: Category=organism-gene. synonym: "Spom-crb2" EXACT PRO-short-label [PRO:DNx] synonym: "DNA repair protein rhp9 (Schizosaccharomyces pombe)" EXACT [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe intersection_of: PR:000016558 ! TP53-binding protein 1 relationship: has_gene_template PomBase:SPBC342.05 ! crb2 (Schizosaccharomyces pombe) [Term] id: PR:P70399 name: TP53-binding protein 1 (mouse) def: "A TP53-binding protein 1 that is encoded in the genome of mouse." [OMA:P70399, PRO:DNx] comment: Category=organism-gene. synonym: "Tp53bp1" RELATED Gene-based [UniProtKB:P70399] synonym: "Trp53bp1" RELATED Gene-based [UniProtKB:P70399] synonym: "mTP53BP1" EXACT PRO-short-label [PRO:DNx] synonym: "53BP1 (mouse)" EXACT [UniProtKB:P70399] synonym: "p53BP1 (mouse)" EXACT [UniProtKB:P70399] synonym: "p53-binding protein 1 (mouse)" EXACT [UniProtKB:P70399] xref: UniProtKB:P70399 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000016558 ! TP53-binding protein 1 relationship: has_gene_template MGI:1351320 ! Trp53bp1 (mouse) [Term] id: PR:000049528 name: TP53-binding protein 1 sumoylated form (human) def: "A TP53-binding protein 1 (human) that includes at least one sumoylated lysine. UniProtKB:Q12888, MOD:01149." [PRO:DNx, Reactome:R-HSA-2997591] comment: Category=organism-modification. synonym: "hTP53BP1/SumoLys+" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q12888, MOD:01149" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-2997591 "PR:000049528 located_in GO:0005654" intersection_of: has_part MOD:01149 ! sumoylated lysine intersection_of: PR:Q12888 ! TP53-binding protein 1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q12888-1 name: TP53-binding protein 1 isoform h1 (human) def: "A TP53-binding protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12888-1." [PRO:DNx, UniProtKB:Q12888] comment: Category=organism-sequence. synonym: "hTP53BP1/iso:h1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q12888-1 is_a: PR:Q12888 ! TP53-binding protein 1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q12888-2 name: TP53-binding protein 1 isoform h2 (human) def: "A TP53-binding protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12888-2." [PRO:DNx, UniProtKB:Q12888] comment: Category=organism-sequence. synonym: "hTP53BP1/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q12888-2 is_a: PR:Q12888 ! TP53-binding protein 1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q12888-3 name: TP53-binding protein 1 isoform h3 (human) def: "A TP53-binding protein 1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q12888-3." [PRO:DNx, UniProtKB:Q12888] comment: Category=organism-sequence. synonym: "hTP53BP1/iso:h3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q12888-3 is_a: PR:Q12888 ! TP53-binding protein 1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000037316 name: DNA repair protein crb2 phosphorylated 1 (Schizosaccharomyces pombe) def: "A DNA repair protein crb2 (Schizosaccharomyces pombe) that is phosphorylated in two Thr residues in CDK consensus TP motifs, and a Thr in the motif VPETV. Example: UniProtKB:P87074, Thr-187/Thr-215/Thr-235, MOD:00047." [PMID:24074952, PomBase:AL] comment: Category=organism-modification. Kinase=("cdc2"; PR:000036301). Requested by=PomBase. synonym: "Crb2 phosphorylated" RELATED [] synonym: "Spom-TP53BP1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P87074, Thr-187/Thr-215/Thr-235, MOD:00047" NARROW PRO-proteoform-std [PRO:DAN] synonym: "DNA repair protein rhp9 phosphorylated 1 (Schizosaccharomyces pombe)" RELATED [PomBase:AL] is_a: PR:000029999 ! DNA repair protein crb2 (Schizosaccharomyces pombe) relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: has_part MOD:00696 ! phosphorylated residue relationship: only_in_taxon NCBITaxon:4896 ! Schizosaccharomyces pombe [Term] id: PR:P87074 name: DNA repair protein crb2 (Schizosaccharomyces pombe 972h-) def: "A TP53-binding protein 1 that is encoded in the genome of Schizosaccharomyces pombe 972h-." [PRO:DNx] comment: Category=organism-gene. synonym: "crb2" RELATED Gene-based [UniProtKB:P87074] synonym: "rhp9" RELATED Gene-based [UniProtKB:P87074] synonym: "SPBC342.05" RELATED Gene-based [UniProtKB:P87074] synonym: "Spom972h-TP53BP1" EXACT PRO-short-label [PRO:DNx] synonym: "RAD9 protein homolog (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:P87074] synonym: "Cut5-repeat binding protein 2 (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:P87074] synonym: "checkpoint mediator protein crb2 (Schizosaccharomyces pombe 972h-)" EXACT [UniProtKB:P87074] xref: UniProtKB:P87074 intersection_of: only_in_taxon NCBITaxon:284812 ! Schizosaccharomyces pombe 972h- intersection_of: PR:000016558 ! TP53-binding protein 1 relationship: has_gene_template PomBase:SPBC342.05 ! crb2 (Schizosaccharomyces pombe) [Term] id: PR:P70399-1 name: TP53-binding protein 1 isoform m1 (mouse) def: "A TP53-binding protein 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70399-1." [PRO:DNx, UniProtKB:P70399] comment: Category=organism-sequence. synonym: "mTP53BP1/iso:m1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P70399-1 is_a: PR:P70399 ! TP53-binding protein 1 (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:Q12888 name: TP53-binding protein 1 (human) def: "A TP53-binding protein 1 that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q12888] comment: Category=organism-gene. synonym: "TP53BP1" RELATED Gene-based [UniProtKB:Q12888] synonym: "hTP53BP1" EXACT PRO-short-label [PRO:DNx] synonym: "53BP1 (human)" EXACT [UniProtKB:Q12888] synonym: "p53BP1 (human)" EXACT [UniProtKB:Q12888] synonym: "p53-binding protein 1 (human)" EXACT [UniProtKB:Q12888] xref: Reactome:R-HSA-61175 "PR:Q12888 located_in GO:0005654" xref: UniProtKB:Q12888 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000016558 ! TP53-binding protein 1 relationship: has_gene_template HGNC:11999 ! TP53BP1 (human) [Term] id: PR:000016558 name: TP53-binding protein 1 def: "A protein that is a translation product of the human TP53BP1 gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "53BP1" EXACT [] synonym: "p53BP1" EXACT [] synonym: "TP53BP1" EXACT PRO-short-label [PRO:DNx] synonym: "Trp53bp1" RELATED Gene-based [] synonym: "p53-binding protein 1" EXACT [] synonym: "tumor suppressor p53-binding protein 1" EXACT [] is_a: PR:000000001 ! protein [Term] id: PR:Q7JKP6 name: protein hsr-9 (worm) def: "A TP53-binding protein 1 that is encoded in the genome of worm." [PANTHER:PTHR15321:SF0, PRO:DNx] comment: Category=organism-gene. synonym: "hsr-9" RELATED Gene-based [UniProtKB:Q7JKP6] synonym: "T05F1.6" RELATED Gene-based [UniProtKB:Q7JKP6] synonym: "53BP1 (worm)" EXACT [UniProtKB:Q7JKP6] synonym: "TP53BP1 (worm)" EXACT PRO-short-label [PRO:DNx] synonym: "heat shock related protein 9 (worm)" EXACT [UniProtKB:Q7JKP6] synonym: "tumor suppressor p53-binding protein 1 homolog (worm)" EXACT [UniProtKB:Q7JKP6] xref: UniProtKB:Q7JKP6 intersection_of: only_in_taxon NCBITaxon:6239 ! Caenorhabditis elegans intersection_of: PR:000016558 ! TP53-binding protein 1 relationship: has_gene_template WormBase:WBGene00002027 ! hsr-9 (worm) [Term] id: PR:000045893 name: TP53-binding protein 1 phosphorylated 1 (human) def: "A TP53-binding protein 1 (human) that has been phosphorylated on the residue at the position equivalent to Ser-1219 of the amino acid sequence represented by UniProtKB:Q12888-1. Example: UniProtKB:Q12888-1, Ser-1219, MOD:00046." [PMID:18996087, iPTMnet:Q12888] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:18996087). Status=unreviewed. synonym: "hTP53BP1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q12888-1, Ser-1219, MOD:00046" NARROW PRO-proteoform-std [PRO:DNx] is_a: PR:Q12888 ! TP53-binding protein 1 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P70399-6 name: TP53-binding protein 1 isoform m3 (mouse) def: "A TP53-binding protein 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70399-6." [PRO:DNx, UniProtKB:P70399] comment: Category=organism-sequence. synonym: "mTP53BP1/iso:m3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P70399-6 is_a: PR:P70399 ! TP53-binding protein 1 (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:P70399-5 name: TP53-binding protein 1 isoform m2 (mouse) def: "A TP53-binding protein 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70399-5." [PRO:DNx, UniProtKB:P70399] comment: Category=organism-sequence. synonym: "mTP53BP1/iso:m2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P70399-5 is_a: PR:P70399 ! TP53-binding protein 1 (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus