[Term]
id: PR:000016879
name: TYRO protein tyrosine kinase-binding protein
def: "A protein that is a translation product of the human TYROBP gene or a 1:1 ortholog thereof." [PRO:DNx]
comment: Category=gene.
synonym: "DAP12" RELATED Gene-based []
synonym: "KARAP" RELATED Gene-based []
synonym: "TYROBP" EXACT PRO-short-label [PRO:DNx]
synonym: "KAR-associated protein" EXACT []
synonym: "DNAX-activation protein 12" EXACT []
synonym: "killer-activating receptor-associated protein" EXACT []
is_a: PR:000000001 ! protein

[Term]
id: PR:O43914-2
name: TYRO protein tyrosine kinase-binding protein isoform h2 (human)
def: "A TYRO protein tyrosine kinase-binding protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43914-2." [PRO:DNx, UniProtKB:O43914]
comment: Category=organism-sequence.
synonym: "hTYROBP/iso:h2" EXACT PRO-short-label [PRO:DNx]
synonym: "TYRO protein tyrosine kinase-binding protein isoform KARAP-b (human)" EXACT [UniProtKB:O43914]
xref: UniProtKB:O43914-2
is_a: PR:O43914 ! TYRO protein tyrosine kinase-binding protein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O43914-3
name: TYRO protein tyrosine kinase-binding protein isoform h3 (human)
def: "A TYRO protein tyrosine kinase-binding protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43914-3." [PRO:DNx, UniProtKB:O43914]
comment: Category=organism-sequence.
synonym: "hTYROBP/iso:h3" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O43914-3
is_a: PR:O43914 ! TYRO protein tyrosine kinase-binding protein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O43914-1
name: TYRO protein tyrosine kinase-binding protein isoform h1 (human)
def: "A TYRO protein tyrosine kinase-binding protein (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O43914-1." [PRO:DNx, UniProtKB:O43914]
comment: Category=organism-sequence.
synonym: "hTYROBP/iso:h1" EXACT PRO-short-label [PRO:DNx]
synonym: "TYRO protein tyrosine kinase-binding protein isoform KARAP-a (human)" EXACT [UniProtKB:O43914]
xref: UniProtKB:O43914-1
is_a: PR:O43914 ! TYRO protein tyrosine kinase-binding protein (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O43914
name: TYRO protein tyrosine kinase-binding protein (human)
def: "A TYRO protein tyrosine kinase-binding protein that is encoded in the genome of human." [PRO:DNx, UniProtKB:O43914]
comment: Category=organism-gene.
synonym: "DAP12" RELATED Gene-based [UniProtKB:O43914]
synonym: "KARAP" RELATED Gene-based [UniProtKB:O43914]
synonym: "TYROBP" RELATED Gene-based [UniProtKB:O43914]
synonym: "hTYROBP" EXACT PRO-short-label [PRO:DNx]
synonym: "KAR-associated protein (human)" EXACT [UniProtKB:O43914]
synonym: "DNAX-activation protein 12 (human)" EXACT [UniProtKB:O43914]
synonym: "killer-activating receptor-associated protein (human)" EXACT [UniProtKB:O43914]
xref: UniProtKB:O43914
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000016879 ! TYRO protein tyrosine kinase-binding protein
relationship: has_gene_template HGNC:12449 ! TYROBP (human)

[Term]
id: PR:000049575
name: TYRO protein tyrosine kinase-binding protein, signal peptide removed phosphorylated 1 (human)
def: "A TYRO protein tyrosine kinase-binding protein (human) that has had the signal peptide removed and has been post-translationally modified to include phosphotyrosine at positions 91 and 102 of the amino acid sequence represented by UniProtKB:O43914. UniProtKB:O43914, 22-113, Tyr-91/Tyr-102, MOD:00048." [PRO:DNx, Reactome:R-HSA-210010]
comment: Category=organism-modification.
synonym: "hTYROBP/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000022603, Tyr-91/Tyr-102, MOD:00048" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:O43914, 22-113, Tyr-91/Tyr-102, MOD:00048" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-210010 "PR:000049575 located_in GO:0005886"
is_a: PR:O43914 ! TYRO protein tyrosine kinase-binding protein (human)
relationship: has_part MOD:00048 ! O4'-phospho-L-tyrosine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part SO:0000418 ! signal_peptide

[Term]
id: PR:000049574
name: TYRO protein tyrosine kinase-binding protein, signal peptide removed form (human)
def: "A TYRO protein tyrosine kinase-binding protein (human) that has had the signal peptide removed. UniProtKB:O43914, 22-113." [PRO:DNx, Reactome:R-HSA-198087]
comment: Category=organism-modification.
synonym: "PRO_0000022603" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hTYROBP/SigPep-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O43914, 22-113" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-198087 "PR:000049574 located_in GO:0005886"
xref: Reactome:R-HSA-6804800 "PR:000049574 located_in GO:0030667"
intersection_of: PR:O43914 ! TYRO protein tyrosine kinase-binding protein (human)
intersection_of: lacks_part SO:0000418 ! signal_peptide
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens