[Term] id: PR:Q14191 name: bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (human) def: "A bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN that is encoded in the genome of human." [PRO:DNx, UniProtKB:Q14191] comment: Category=organism-gene. synonym: "WRN" RELATED Gene-based [UniProtKB:Q14191] synonym: "hWRN" EXACT PRO-short-label [PRO:DNx] synonym: "RECQ3" RELATED Gene-based [UniProtKB:Q14191] synonym: "RECQL2" RELATED Gene-based [UniProtKB:Q14191] synonym: "RecQ protein-like 2 (human)" EXACT [UniProtKB:Q14191] synonym: "Werner syndrome protein (human)" EXACT [UniProtKB:Q14191] synonym: "DNA helicase, RecQ-like type 3 (human)" EXACT [UniProtKB:Q14191] xref: Reactome:R-HSA-67387 "PR:Q14191 located_in GO:0005654" xref: UniProtKB:Q14191 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000017455 ! bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN relationship: has_gene_template HGNC:12791 ! WRN (human) [Term] id: PR:000049701 name: bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN sumoylated 1 (human) def: "A bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (human) that has been post-translationally modified to include sumoylated lysine at positions 356, 496 and 898 of the amino acid sequence represented by UniProtKB:Q14191. UniProtKB:Q14191, Lys-356/Lys-496/Lys-898, MOD:01149." [PRO:DNx, Reactome:R-HSA-4568904] comment: Category=organism-modification. synonym: "hWRN/Sumo:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q14191, Lys-356/Lys-496/Lys-898, MOD:01149" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-4568904 "PR:000049701 located_in GO:0005654" is_a: PR:Q14191 ! bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (human) relationship: has_part MOD:01149 ! sumoylated lysine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000017455 name: bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN def: "A protein that is a translation product of the human WRN gene or a 1:1 ortholog thereof." [PRO:DNx] comment: Category=gene. synonym: "WRN" EXACT PRO-short-label [PRO:DNx] synonym: "RECQ3" RELATED Gene-based [] synonym: "RecQ3" EXACT [] synonym: "RECQL2" RELATED Gene-based [] synonym: "exonuclease WRN" EXACT [] synonym: "RecQ protein-like 2" EXACT [] synonym: "DNA helicase, RecQ-like type 3" EXACT [] synonym: "Werner syndrome ATP-dependent helicase" EXACT [] is_a: PR:000000001 ! protein