[Term]
id: PR:000044893
name: histone H2A type 1-G/I/K/L/M, initiator methionine removed acetylated 2 (human)
def: "A histone H2A type 1-G/I/K/L/M (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-10 of the amino acid sequence represented by UniProtKB:P0C0S8. UniProtKB:P0C0S8, 2-130, Lys-10, MOD:00064." [HIstome_var_Hs:Histone_H2A_type_1, PMID:12937907, PMID:18552846, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1:H2AK9ac" BROAD [HIstome_ptm_Hs:H2AK9ac]
synonym: "PRO_0000055235, Lys-10, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hHIST1H2A[G/I/K/L/M]/InitMet-/Ac:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P0C0S8, 2-130, Lys-10, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P0C0S8 ! histone H2A type 1-G/I/K/L/M (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044892
name: histone H2A type 1-G/I/K/L/M, initiator methionine removed biotinylated 2 (human)
def: "A histone H2A type 1-G/I/K/L/M (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-14 of the amino acid sequence represented by UniProtKB:P0C0S8. UniProtKB:P0C0S8, 2-130, Lys-14, MOD:00126." [HIstome_var_Hs:Histone_H2A_type_1, PMID:16772434, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1:H2AK13bio" BROAD [HIstome_ptm_Hs:H2AK13bio]
synonym: "PRO_0000055235, Lys-14, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hHIST1H2A[G/I/K/L/M]/InitMet-/Btn:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P0C0S8, 2-130, Lys-14, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P0C0S8 ! histone H2A type 1-G/I/K/L/M (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044891
name: histone H2A type 1-G/I/K/L/M, initiator methionine removed phosphorylated 1 (human)
def: "A histone H2A type 1-G/I/K/L/M (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Ser-2 of the amino acid sequence represented by UniProtKB:P0C0S8. UniProtKB:P0C0S8, 2-130, Ser-2, MOD:00046." [HIstome_var_Hs:Histone_H2A_type_1, PMID:15010469, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1:H2AS1ph" BROAD [HIstome_ptm_Hs:H2AS1ph]
synonym: "PRO_0000055235, Ser-2, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hHIST1H2A[G/I/K/L/M]/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P0C0S8, 2-130, Ser-2, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P0C0S8 ! histone H2A type 1-G/I/K/L/M (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044890
name: histone H2A type 1-G/I/K/L/M, initiator methionine removed ubiquitinated 1 (human)
def: "A histone H2A type 1-G/I/K/L/M (human) that has had the initiator methionine removed and that has been ubiquitinated on the lysine at the position equivalent to Lys-120 of the amino acid sequence represented by UniProtKB:P0C0S8. UniProtKB:P0C0S8, 2-130, Lys-120, MOD:01148." [HIstome_var_Hs:Histone_H2A_type_1, PMID:15386022, PMID:18400894, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1:H2AK119ub" BROAD [HIstome_ptm_Hs:H2AK119ub]
synonym: "PRO_0000055235, Lys-120, MOD:01148" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hHIST1H2A[G/I/K/L/M]/InitMet-/Ubiq:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P0C0S8, 2-130, Lys-120, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-6782508 "PR:000044890 located_in GO:0005654"
is_a: PR:P0C0S8 ! histone H2A type 1-G/I/K/L/M (human)
relationship: has_part MOD:01148 ! ubiquitinylated lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044897
name: histone H2A type 1-G/I/K/L/M, initiator methionine removed biotinylated 5 (human)
def: "A histone H2A type 1-G/I/K/L/M (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-128 of the amino acid sequence represented by UniProtKB:P0C0S8. UniProtKB:P0C0S8, 2-130, Lys-128, MOD:00126." [HIstome_var_Hs:Histone_H2A_type_1, PMID:16109483, PMID:16772434, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1:H2AK127bio" BROAD [HIstome_ptm_Hs:H2AK127bio]
synonym: "PRO_0000055235, Lys-128, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hHIST1H2A[G/I/K/L/M]/InitMet-/Btn:5" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P0C0S8, 2-130, Lys-128, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P0C0S8 ! histone H2A type 1-G/I/K/L/M (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044895
name: histone H2A type 1-G/I/K/L/M, initiator methionine removed dimethylated 1 (human)
def: "A histone H2A type 1-G/I/K/L/M (human) that has had the initiator methionine removed and that has been dimethylated at the position equivalent to Arg-4 of the amino acid sequence represented by UniProtKB:P0C0S8. UniProtKB:P0C0S8, 2-130, Arg-4, MOD:00783." [HIstome_var_Hs:Histone_H2A_type_1, PMID:18079182, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1:H2AR3me2" BROAD [HIstome_ptm_Hs:H2AR3me2]
synonym: "PRO_0000055235, Arg-4, MOD:00783" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hHIST1H2A[G/I/K/L/M]/InitMet-/Me2:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P0C0S8, 2-130, Arg-4, MOD:00783" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P0C0S8 ! histone H2A type 1-G/I/K/L/M (human)
relationship: has_part MOD:00783 ! dimethylated L-arginine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044886
name: histone H2A type 1-G/I/K/L/M, initiator methionine removed biotinylated 1 (human)
def: "A histone H2A type 1-G/I/K/L/M (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-130 of the amino acid sequence represented by UniProtKB:P0C0S8. UniProtKB:P0C0S8, 2-130, Lys-130, MOD:00126." [HIstome_var_Hs:Histone_H2A_type_1, PMID:16109483, PMID:16772434, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1:H2AK129bio" BROAD [HIstome_ptm_Hs:H2AK129bio]
synonym: "PRO_0000055235, Lys-130, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hHIST1H2A[G/I/K/L/M]/InitMet-/Btn:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P0C0S8, 2-130, Lys-130, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P0C0S8 ! histone H2A type 1-G/I/K/L/M (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044887
name: histone H2A type 1-G/I/K/L/M, initiator methionine removed citrullinated 1 (human)
def: "A histone H2A type 1-G/I/K/L/M (human) that has had the initiator methionine removed and that has been citrullinated at the position equivalent to Arg-4 of the amino acid sequence represented by UniProtKB:P0C0S8. UniProtKB:P0C0S8, 2-130, Arg-4, MOD:00219." [HIstome_var_Hs:Histone_H2A_type_1, PMID:15823041, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1:H2AR3ci" BROAD [HIstome_ptm_Hs:H2AR3ci]
synonym: "PRO_0000055235, Arg-4, MOD:00219" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hHIST1H2A[G/I/K/L/M]/InitMet-/Cit:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P0C0S8, 2-130, Arg-4, MOD:00219" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P0C0S8 ! histone H2A type 1-G/I/K/L/M (human)
relationship: has_part MOD:00219 ! L-citrulline
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044888
name: histone H2A type 1-G/I/K/L/M, initiator methionine removed ADP-ribosylated 1 (human)
def: "A histone H2A type 1-G/I/K/L/M (human) that has had the initiator methionine removed and that has been ADP-ribosylated at the position equivalent to Lys-14 of the amino acid sequence represented by UniProtKB:P0C0S8. UniProtKB:P0C0S8, 2-130, Lys-14, MOD:01399." [HIstome_var_Hs:Histone_H2A_type_1, PMID:20525793, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1:H2AK13ar" BROAD [HIstome_ptm_Hs:H2AK13ar]
synonym: "PRO_0000055235, Lys-14, MOD:01399" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hHIST1H2A[G/I/K/L/M]/InitMet-/ADPrib:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P0C0S8, 2-130, Lys-14, MOD:01399" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P0C0S8 ! histone H2A type 1-G/I/K/L/M (human)
relationship: has_part MOD:01399 ! N6-(ADP-ribosyl)-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000035694
name: histone H2A type 1-G/I/K/L/M unphosphorylated form (human)
def: "A histone H2A type 1-G/I/K/L/M (human) that lacks phosphorylated residues." [PRO:DAN, PRO:KER]
comment: Category=organism-modification.
synonym: "hHIST1H2A[G/I/K/L/M]/UnMod" EXACT PRO-short-label [PRO:DNx]
intersection_of: lacks_part MOD:00696 ! phosphorylated residue
intersection_of: PR:P0C0S8 ! histone H2A type 1-G/I/K/L/M (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000044894
name: histone H2A type 1-G/I/K/L/M, initiator methionine removed biotinylated 3 (human)
def: "A histone H2A type 1-G/I/K/L/M (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-10 of the amino acid sequence represented by UniProtKB:P0C0S8. UniProtKB:P0C0S8, 2-130, Lys-10, MOD:00126." [HIstome_var_Hs:Histone_H2A_type_1, PMID:16772434, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1:H2AK9bio" BROAD [HIstome_ptm_Hs:H2AK9bio]
synonym: "PRO_0000055235, Lys-10, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hHIST1H2A[G/I/K/L/M]/InitMet-/Btn:3" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P0C0S8, 2-130, Lys-10, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P0C0S8 ! histone H2A type 1-G/I/K/L/M (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000044898
name: histone H2A type 1-G/I/K/L/M, initiator methionine removed phosphorylated 2 (human)
def: "A histone H2A type 1-G/I/K/L/M (human) that has had the initiator methionine removed and that has been phosphorylated on the residue at the position equivalent to Thr-121 of the amino acid sequence represented by UniProtKB:P0C0S8. UniProtKB:P0C0S8, 2-130, Thr-121, MOD:00047." [HIstome_var_Hs:Histone_H2A_type_1, PMID:11756469, PMID:14667408, PMID:19965387, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification. Kinase=("BUB1"; PR:O43683). [PRO:KER, PMID:19965387]
synonym: "H2A_type_1:H2AT120ph" BROAD [HIstome_ptm_Hs:H2AT120ph]
synonym: "PRO_0000055235, Thr-121, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hHIST1H2A[G/I/K/L/M]/InitMet-/Phos:2" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P0C0S8, 2-130, Thr-121, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P0C0S8 ! histone H2A type 1-G/I/K/L/M (human)
relationship: has_part MOD:00047 ! O-phospho-L-threonine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:P0C0S8
name: histone H2A type 1-G/I/K/L/M (human)
def: "A histone H2A type 1-G/I/K/L/M that is encoded in the genome of human." [PRO:DAN]
comment: Category=organism-gene. Note: The HIST1H2AG, HIST1H2AI, HIST1H2AK, HIST1H2AL, and HIST1H2AM genes encode identical proteins.
synonym: "H2AFC" RELATED Gene-based [UniProtKB:P0C0S8]
synonym: "H2AFD" RELATED Gene-based [UniProtKB:P0C0S8]
synonym: "H2AFI" RELATED Gene-based [UniProtKB:P0C0S8]
synonym: "H2AFN" RELATED Gene-based [UniProtKB:P0C0S8]
synonym: "H2AFP" RELATED Gene-based [UniProtKB:P0C0S8]
synonym: "H2AC11" RELATED Gene-based [UniProtKB:P0C0S8]
synonym: "H2AC13" RELATED Gene-based [UniProtKB:P0C0S8]
synonym: "H2AC15" RELATED Gene-based [UniProtKB:P0C0S8]
synonym: "H2AC16" RELATED Gene-based [UniProtKB:P0C0S8]
synonym: "H2AC17" RELATED Gene-based [UniProtKB:P0C0S8]
synonym: "HIST1H2AG" RELATED Gene-based [UniProtKB:P0C0S8]
synonym: "HIST1H2AI" RELATED Gene-based [UniProtKB:P0C0S8]
synonym: "HIST1H2AK" RELATED Gene-based [UniProtKB:P0C0S8]
synonym: "HIST1H2AL" RELATED Gene-based [UniProtKB:P0C0S8]
synonym: "HIST1H2AM" RELATED Gene-based [UniProtKB:P0C0S8]
synonym: "H2A.1 (human)" EXACT [UniProtKB:P0C0S8]
synonym: "hHIST1H2A[G/I/K/L/M]" EXACT PRO-short-label [PRO:DNx]
synonym: "histone H2A/ptl (human)" EXACT [UniProtKB:P0C0S8]
xref: UniProtKB:P0C0S8
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000029528 ! histone H2A type 1-G/I/K/L/M
relationship: has_gene_template HGNC:4725 ! HIST1H2AI (human)
relationship: has_gene_template HGNC:4726 ! HIST1H2AK (human)
relationship: has_gene_template HGNC:4730 ! HIST1H2AL (human)
relationship: has_gene_template HGNC:4735 ! HIST1H2AM (human)
relationship: has_gene_template HGNC:4737 ! HIST1H2AG (human)

[Term]
id: PR:000044889
name: histone H2A type 1-G/I/K/L/M, initiator methionine removed acetylated 1 (human)
def: "A histone H2A type 1-G/I/K/L/M (human) that has had the initiator methionine removed and that has been acetylated at the position equivalent to Lys-6 of the amino acid sequence represented by UniProtKB:P0C0S8. UniProtKB:P0C0S8, 2-130, Lys-6, MOD:00064." [HIstome_var_Hs:Histone_H2A_type_1, PMID:17709392, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1:H2AK5ac" BROAD [HIstome_ptm_Hs:H2AK5ac]
synonym: "PRO_0000055235, Lys-6, MOD:00064" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hHIST1H2A[G/I/K/L/M]/InitMet-/Ac:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P0C0S8, 2-130, Lys-6, MOD:00064" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-4568595 "PR:000044889 located_in GO:0005654"
is_a: PR:P0C0S8 ! histone H2A type 1-G/I/K/L/M (human)
relationship: has_part MOD:00064 ! N6-acetyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000029528
name: histone H2A type 1-G/I/K/L/M
def: "A histone H2A that is a translation product of the human HIST1H2AG, HIST1H2AI, HIST1H2AK, HIST1H2AL, or HIST1H2AM genes, 1:1 orthologs thereof, or a semi-ortholog thereof." [PRO:DAN]
comment: Category=gene. Note: The human HIST1H2AG, HIST1H2AI, HIST1H2AK, HIST1H2AL, and HIST1H2AM genes encode identical proteins.
synonym: "H2A.1" BROAD [PRO:DNx]
synonym: "H2AFC" NARROW Gene-based [PRO:DAN]
synonym: "H2AFD" NARROW Gene-based [PRO:DAN]
synonym: "H2AFI" NARROW Gene-based [PRO:DAN]
synonym: "H2AFN" NARROW Gene-based [PRO:DAN]
synonym: "H2AFP" NARROW Gene-based [PRO:DAN]
synonym: "H2AC11" NARROW Gene-based [PRO:DAN]
synonym: "H2AC13" NARROW Gene-based [PRO:DAN]
synonym: "H2AC15" NARROW Gene-based [PRO:DAN]
synonym: "H2AC16" NARROW Gene-based [PRO:DAN]
synonym: "H2AC17" NARROW Gene-based [PRO:DAN]
synonym: "HIST1H2AG" NARROW Gene-based [PRO:DAN]
synonym: "HIST1H2AI" NARROW Gene-based [PRO:DAN]
synonym: "HIST1H2AK" NARROW Gene-based [PRO:DAN]
synonym: "HIST1H2AL" NARROW Gene-based [PRO:DAN]
synonym: "HIST1H2AM" NARROW Gene-based [PRO:DAN]
synonym: "histone H2A/p" NARROW [PRO:DAN]
synonym: "histone H2A type 1" BROAD [PRO:DNx]
synonym: "HIST1H2A[G/I/K/L/M]" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000027547 ! histone H2A

[Term]
id: PR:000044896
name: histone H2A type 1-G/I/K/L/M, initiator methionine removed biotinylated 4 (human)
def: "A histone H2A type 1-G/I/K/L/M (human) that has had the initiator methionine removed and that has been biotinylated at the position equivalent to Lys-126 of the amino acid sequence represented by UniProtKB:P0C0S8. UniProtKB:P0C0S8, 2-130, Lys-126, MOD:00126." [HIstome_var_Hs:Histone_H2A_type_1, PMID:16109483, PMID:16772434, PRO:DAN, PRO:JPB, PRO:JR]
comment: Category=organism-modification.
synonym: "H2A_type_1:H2AK125bio" BROAD [HIstome_ptm_Hs:H2AK125bio]
synonym: "PRO_0000055235, Lys-126, MOD:00126" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hHIST1H2A[G/I/K/L/M]/InitMet-/Btn:4" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P0C0S8, 2-130, Lys-126, MOD:00126" EXACT PRO-proteoform-std [PRO:DNx]
is_a: PR:P0C0S8 ! histone H2A type 1-G/I/K/L/M (human)
relationship: has_part MOD:00126 ! N6-biotinyl-L-lysine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine