[Term] id: PR:000037467 name: LPS:secreted CD14 complex (mouse) def: "An LPS:secreted CD14 complex whose components are encoded in the genome of mouse." [PMID:10601848, PMID:18606699] comment: Category=organism-complex. Requested by=TLR. Note: PMID:10601848 shows evidence for complex in Figure 1, and indicates in the discussion that it uses the high M(r) form of sCD14. However, the authors show that the specific form of sCD14 found has the same M(r) as the mCD14, which is a hallmark of the shorter form. For this reason we consider the actual form used to be unclear. In PMID:18606699, evidence is indirect from response of endothelial epithelium to LPS with sCD14 depleted mouse plasma compared to normal. synonym: "m-LPS:sCD14" EXACT PRO-short-label [PRO:DAN] synonym: "sCD14/LPS complex (mouse)" EXACT [] is_a: PR:000029989 ! LPS:secreted CD14 complex relationship: has_component CHEBI:16412 ! lipopolysaccharide relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus relationship: has_component PR:000036850 ! CD14 molecule isoform 1 cleaved and soluble form (mouse) [Term] id: PR:000029989 name: LPS:secreted CD14 complex def: "An LPS:CD14 complex that contains a soluble form of CD14 bound to lipopolysaccharides (LPS)." [PRO:DAN] comment: Category=complex. synonym: "LPS:sCD14" EXACT PRO-short-label [PRO:DAN] is_a: PR:000037465 ! LPS:CD14 complex relationship: has_component CHEBI:16412 ! lipopolysaccharide relationship: has_component PR:000036849 ! CD14 molecule isoform 1 cleaved and soluble form [Term] id: PR:000025494 name: LPS:secreted CD14 alpha def: "An LPS:secreted CD14 complex that contains the low M(r) soluble form of CD14 bound to lipopolysaccharides (LPS)." [PMID:16861002, PMID:7681988, PRO:CNA, PRO:DAN] comment: Category=complex. synonym: "LPS:sCD14alpha" EXACT PRO-short-label [PRO:DAN] synonym: "CD14sLPS complex" EXACT [TLR:AMM] synonym: "sCD14/LPS complex" EXACT [] intersection_of: has_component PR:000002147 ! CD14 molecule isoform 1 cleaved 2 soluble form intersection_of: PR:000029989 ! LPS:secreted CD14 complex relationship: has_component CHEBI:16412 ! lipopolysaccharide [Term] id: PR:000037463 name: LPS:secreted CD14 alpha (human) def: "An LPS:secreted CD14 alpha whose components are encoded in the genome of human." [Reactome:R-HSA-166026] comment: Category=organism-complex. synonym: "h-LPS:sCD14alpha" EXACT PRO-short-label [PRO:DAN] synonym: "sCD14/LPS complex (human)" EXACT [] xref: Reactome:R-HSA-166026 "PR:000037463 located_in GO:0005576" is_a: PR:000025494 ! LPS:secreted CD14 alpha relationship: has_component CHEBI:16412 ! lipopolysaccharide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens relationship: has_component PR:000035703 ! CD14 molecule isoform 1 cleaved 2 soluble form (human)