[Term] id: PR:P29990 name: genome polyprotein (Dengue virus 2 Thailand/16681/84) def: "A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 Thailand/16681/84." [PRO:ES] comment: Category=organism-gene. synonym: "polyprot (DEN26)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P29990 intersection_of: only_in_taxon NCBITaxon:31634 ! Dengue virus 2 Thailand/16681/84 intersection_of: PR:000036816 ! dengue virus genome polyprotein [Term] id: PR:P17763 name: genome polyprotein (Dengue virus 1 Nauru/West Pac/1974) def: "A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 1 Nauru/West Pac/1974." [PRO:ES] comment: Category=organism-gene. synonym: "polyprot" RELATED Gene-based [UniProtKB:P17763] synonym: "polyprot (DEN1W)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P17763 intersection_of: only_in_taxon NCBITaxon:11059 ! Dengue virus 1 Nauru/West Pac/1974 intersection_of: PR:000036816 ! dengue virus genome polyprotein relationship: has_gene_template NCBIGene:5075725 ! polyprot (Dengue virus 1 Nauru/West Pac/1974) [Term] id: PR:000044757 name: M protein (Dengue virus 2 Thailand/16681/84) def: "An M protein in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 206-280." [PRO:DNx] comment: Category=organism-modification. synonym: "M (DEN26)" EXACT PRO-short-label [PRO:DAN] synonym: "PRO_0000037927" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P29990, 206-280" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:31634 ! Dengue virus 2 Thailand/16681/84 intersection_of: PR:000036821 ! M protein [Term] id: PR:000036841 name: NS4AB def: "A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS4A-NS4B-NS5 by the two-component proteinase NS2B-NS3 at the NS4B-NS5 sites consisting of NS4A, 2K, and NS4B." [PMID:1531368, PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "NS4A-NS4B" EXACT [] synonym: "DenV-NS4AB" EXACT PRO-short-label [PRO:DAN] synonym: "NS4A-2K-NS4B" EXACT [] intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: has_part PR:000036830 ! NS4A intersection_of: has_part PR:000036831 ! 2K intersection_of: has_part PR:000036833 ! NS4B intersection_of: lacks_part PR:000036835 ! NS5 intersection_of: derives_from PR:000036840 ! NS4A-NS4B-NS5 [Term] id: PR:000036840 name: NS4A-NS4B-NS5 def: "A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS345 by the two-component proteinase NS2B-NS3 at the NS3-NS4A site consisting of NS4A, 2K, NS4B, and NS5." [PMID:1531368, PRO:ES] comment: Category=modification. Requested by=IDODEN. The polyprotein NS4A-NS4B-NS5 was cleaved at the NS4A/NS4B junction in the absence of other dengue virus functions. synonym: "DenV-NS4AB5" EXACT PRO-short-label [PRO:DAN] intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: lacks_part PR:000036828 ! NS3 intersection_of: has_part PR:000036830 ! NS4A intersection_of: has_part PR:000036831 ! 2K intersection_of: has_part PR:000036833 ! NS4B intersection_of: has_part PR:000036835 ! NS5 intersection_of: derives_from PR:000036839 ! NS345 [Term] id: PR:000036843 name: NS4B-NS5 def: "A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS4A-NS4B-NS5 at the NS4A-NS4B site consisting of NS4B and NS5, which is believed to be mediated by a host cell signal peptidase." [PMID:1531368, PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "NS4B5" EXACT [] synonym: "DenV-NS4B5" EXACT PRO-short-label [PRO:DAN] intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: lacks_part PR:000036830 ! NS4A intersection_of: lacks_part PR:000036831 ! 2K intersection_of: has_part PR:000036833 ! NS4B intersection_of: has_part PR:000036835 ! NS5 intersection_of: derives_from PR:000036840 ! NS4A-NS4B-NS5 [Term] id: PR:000036842 name: 2KNS4B def: "A dengue virus genome polyprotein proteolytic cleavage product that assists in the processing of NS4AB consisting of 2K and NS4B." [PMID:21810535, PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "DenV-2KNS4B" EXACT PRO-short-label [PRO:DAN] intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: lacks_part PR:000036830 ! NS4A intersection_of: has_part PR:000036831 ! 2K intersection_of: has_part PR:000036833 ! NS4B intersection_of: derives_from PR:000036841 ! NS4AB [Term] id: PR:Q5UCB8 name: genome polyprotein (Dengue virus 4 Singapore/8976/1995) def: "A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 4 Singapore/8976/1995." [PRO:ES] comment: Category=organism-gene. synonym: "polyprot (DEN4S)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q5UCB8 intersection_of: only_in_taxon NCBITaxon:408687 ! Dengue virus 4 Singapore/8976/1995 intersection_of: PR:000036816 ! dengue virus genome polyprotein [Term] id: PR:P27909 name: genome polyprotein (Dengue virus 1 Brazil/97-11/1997) def: "A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 1 Brazil/97-11/1997." [PRO:ES] comment: Category=organism-gene. synonym: "polyprot (DEN1B)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P27909 intersection_of: only_in_taxon NCBITaxon:408685 ! Dengue virus 1 Brazil/97-11/1997 intersection_of: PR:000036816 ! dengue virus genome polyprotein [Term] id: PR:Q9WDA6 name: genome polyprotein (Dengue virus 2 Peru/IQT2913/1996) def: "A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 Peru/IQT2913/1996." [PRO:ES] comment: Category=organism-gene. synonym: "polyprot (DEN2Q)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q9WDA6 intersection_of: only_in_taxon NCBITaxon:408694 ! Dengue virus 2 Peru/IQT2913/1996 intersection_of: PR:000036816 ! dengue virus genome polyprotein [Term] id: PR:Q99D35 name: genome polyprotein (Dengue virus 3 China/80-2/1980) def: "A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 3 China/80-2/1980." [PRO:ES] comment: Category=organism-gene. synonym: "polyprot (DEN3C)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q99D35 intersection_of: only_in_taxon NCBITaxon:408690 ! Dengue virus 3 China/80-2/1980 intersection_of: PR:000036816 ! dengue virus genome polyprotein [Term] id: PR:P29991 name: genome polyprotein (Dengue virus 2 16681-PDK53) def: "A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 16681-PDK53." [PRO:ES] comment: Category=organism-gene. synonym: "polyprot (DEN27)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P29991 intersection_of: only_in_taxon NCBITaxon:31635 ! Dengue virus 2 16681-PDK53 intersection_of: PR:000036816 ! dengue virus genome polyprotein [Term] id: PR:Q6YMS3 name: genome polyprotein (Dengue virus 3 Martinique/1243/1999) def: "A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 3 Martinique/1243/1999." [PRO:ES] comment: Category=organism-gene. synonym: "pol" RELATED Gene-based [UniProtKB:Q6YMS3] synonym: "polyprot (DEN3M)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q6YMS3 intersection_of: only_in_taxon NCBITaxon:408691 ! Dengue virus 3 Martinique/1243/1999 intersection_of: PR:000036816 ! dengue virus genome polyprotein [Term] id: PR:000036828 name: NS3 def: "A dengue virus genome polyprotein proteolytic cleavage product that is a non-structural, multifunctional protein encoded by the dengue virus RNA genome with a serine protease domain." [PMID:10744671, PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "NS3pro" EXACT [] synonym: "DenV-NS3" EXACT PRO-short-label [PRO:DAN] synonym: "serine protease NS3" EXACT [] synonym: "Non-structural protein 3" EXACT [] synonym: "Flavivirin protease NS3 catalytic subunit" EXACT [] intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: lacks_part PR:000036830 ! NS4A intersection_of: lacks_part PR:000036831 ! 2K intersection_of: lacks_part PR:000036833 ! NS4B intersection_of: lacks_part PR:000036835 ! NS5 intersection_of: derives_from PR:000036839 ! NS345 [Term] id: PR:000036827 name: NS2B def: "A dengue virus genome polyprotein proteolytic cleavage product that is a non-structural protein encoded by the dengue virus RNA genome containing a conserved hydrophilic domain necessary for protease activity in cleavage of the dengue virus genome polyprotein, N-glycosylated form." [PMID:10744671, PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "DenV-NS2B" EXACT PRO-short-label [PRO:DAN] synonym: "Non-structural protein 2B" EXACT [] synonym: "Serine protease subunit NS2B" EXACT [] synonym: "Flavivirin protease NS2B regulatory subunit" EXACT [] intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: lacks_part PR:000036824 ! NS1 intersection_of: lacks_part PR:000036825 ! NS2A intersection_of: lacks_part PR:000036826 ! NS2A-alpha intersection_of: lacks_part PR:000036828 ! NS3 intersection_of: lacks_part PR:000036830 ! NS4A intersection_of: lacks_part PR:000036831 ! 2K intersection_of: lacks_part PR:000036833 ! NS4B intersection_of: lacks_part PR:000036835 ! NS5 intersection_of: derives_from PR:000036838 ! NS12345 [Term] id: PR:000036826 name: NS2A-alpha def: "A dengue virus genome polyprotein proteolytic cleavage product that consists of 188 amino acids at the N-terminal end of NS2A." [PMID:23408612, PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "DenV-NS2Aalpha" EXACT PRO-short-label [PRO:DAN] synonym: "Non-structural protein 2A-alpha" EXACT [] intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: lacks_part PR:000036824 ! NS1 intersection_of: lacks_part PR:000036825 ! NS2A intersection_of: lacks_part PR:000036827 ! NS2B intersection_of: lacks_part PR:000036828 ! NS3 intersection_of: lacks_part PR:000036830 ! NS4A intersection_of: lacks_part PR:000036831 ! 2K intersection_of: lacks_part PR:000036833 ! NS4B intersection_of: lacks_part PR:000036835 ! NS5 intersection_of: derives_from PR:000036838 ! NS12345 [Term] id: PR:000036825 name: NS2A def: "A dengue virus genome polyprotein proteolytic cleavage product that is a non-structural protein encoded by the dengue virus RNA genome and a component of the viral replication complex." [PMID:23408612, PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "DenV-NS2A" EXACT PRO-short-label [PRO:DAN] synonym: "Non-structural protein 2A" EXACT [] intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: lacks_part PR:000036824 ! NS1 intersection_of: derives_from PR:000036998 ! NS1-NS2A [Term] id: PR:000036824 name: NS1 def: "A dengue virus genome polyprotein proteolytic cleavage product that is the N-terminal most non-structural protein within the dengue virus genome polyprotein. Example: UniProtKB:P29990, 776-1127, Asn-905/Asn-982, MOD:00160." [PRO:ES] comment: Category=modification. Requested by=IDODEN. NS1 is a secreted glycoprotein that is absent from viral particles but accumulates in the supernatant and on the plasma membrane of cells during infection. Because it derives from a glycosylated precursor it includes two N-glycosylated residues at Asn-130 and Asn-207. [PMID:18052531, PRO:ES]. synonym: "DenV-NS1" EXACT PRO-short-label [PRO:DAN] synonym: "non-structural protein 1" EXACT [] intersection_of: has_part MOD:00160 ! N4-glycosyl-L-asparagine intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: lacks_part PR:000036825 ! NS2A intersection_of: derives_from PR:000036998 ! NS1-NS2A [Term] id: PR:000036822 name: E protein def: "A dengue virus genome polyprotein proteolytic cleavage product that is a structural protein containing two alpha-helices (EH1 and EH2) at the C-terminus and two transmembrane domains (ET1 and ET2) of the dengue virus RNA genome. It contains two N-linked glycosylation sites, at Asn-67 and Asn-153. Example: UniProtKB:P29990, 281-775, Asn-347/Asn-433, MOD:00160." [PMID:17459925, PMID:23300717, PRO:DAN, PRO:ES] comment: Category=modification. Requested by=IDODEN. The E protein is responsible for eliciting the majority of the protective dengue virus antibody response. It covers the virion surface arranged in anti-parallel dimers containing three structural and antigenic domains [PMID:22709350, PRO:ES]. synonym: "DenV-E" EXACT PRO-short-label [PRO:DAN] synonym: "Envelope protein E" EXACT [] intersection_of: has_part MOD:00160 ! N4-glycosyl-L-asparagine intersection_of: derives_from PR:000036817 ! dengue virus genome polyprotein, N-glycosylated form intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: lacks_part PR:000036836 ! C-prM intersection_of: lacks_part PR:000036838 ! NS12345 [Term] id: PR:000036821 name: M protein def: "A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from its precursor prM and localizes to the endoplasmic reticulum and forms oligomers." [PMID:22569259, PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "DenV-M" EXACT PRO-short-label [PRO:DAN] synonym: "M peptide" EXACT [] synonym: "membrane protein" EXACT [] synonym: "small envelope protein M" EXACT [] synonym: "membrane-associated virion protein" EXACT [] intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: lacks_part PR:000036820 ! pr protein intersection_of: derives_from PR:000036837 ! prM [Term] id: PR:000036820 name: pr protein def: "A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from its precursor form prM protein on the surface of immature dengue virus by host protease during virion maturation." [PMID:23559476, PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "DenV-pr" EXACT PRO-short-label [PRO:DAN] synonym: "peptide pr" EXACT [] synonym: "non-M fragment" EXACT [] intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: lacks_part PR:000036821 ! M protein intersection_of: derives_from PR:000036837 ! prM [Term] id: PR:Q2YHF2 name: genome polyprotein (Dengue virus 4 Thailand/0476/1997) def: "A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 4 Thailand/0476/1997." [PRO:ES] comment: Category=organism-gene. synonym: "polyprot (DEN4H)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q2YHF2 intersection_of: only_in_taxon NCBITaxon:408689 ! Dengue virus 4 Thailand/0476/1997 intersection_of: PR:000036816 ! dengue virus genome polyprotein [Term] id: PR:000044768 name: NS5 (Dengue virus 2 Thailand/NGS-C/1944) def: "An NS5 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2492-3391." [PRO:DNx] comment: Category=organism-modification. synonym: "NS5 (DEN2N)" EXACT PRO-short-label [PRO:DAN] synonym: "PRO_0000037968" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P14340, 2492-3391" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:11065 ! Dengue virus 2 Thailand/NGS-C/1944 intersection_of: PR:000036835 ! NS5 [Term] id: PR:000036816 name: dengue virus genome polyprotein def: "A protein that is a translation product of the dengue virus serotype 2 genomic RNA or a 1:1 ortholog thereof." [PRO:ES] comment: Category=gene. Requested by=IDODEN. The dengue virus contains a 10.7 kb single-stranded RNA genome of positive strand polarity with a type I cap at the 5' terminus. The RNA genome is translated into a large glycosylated polyprotein precursor with proteins that are arranged in the order NH2-C-prM-E-NS1-NS2A-NS2B-NS3-NS4A-NS4B-NS5-COOH. Proteolytic processing in the region of the structural proteins is mediated by a host cell signal peptidase that is located within the endoplasmic reticulum. [PMID:12297031, PRO:ES] synonym: "DenV-polyprot" EXACT PRO-short-label [PRO:DAN] is_a: PR:000000001 ! protein [Term] id: PR:000036817 name: dengue virus genome polyprotein, N-glycosylated form def: "A dengue virus genome polyprotein that has been post-translationally modified to include N-glycosylated residues at Asn-183, Asn-347, Asn-433, Asn-905, and Asn-982. Example: UniProtKB:P29990, 1-3391, Asn-183/Asn-347/Asn-433/Asn-905/Asn-982, MOD:00160." [PRO:DAN, PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "DenV-polyprot/NGlycoAsn+" EXACT PRO-short-label [PRO:DAN] intersection_of: has_part MOD:00160 ! N4-glycosyl-L-asparagine intersection_of: PR:000036816 ! dengue virus genome polyprotein [Term] id: PR:000044769 name: prM (Dengue virus 2 Thailand/16681/84) def: "A prM in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 115-280, Asn-183, MOD:00160." [PRO:DNx] comment: Category=organism-modification. synonym: "prM (DEN26)" EXACT PRO-short-label [PRO:DAN] synonym: "PRO_0000264673, Asn-183, MOD:00160" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P29990, 115-280, Asn-183, MOD:00160" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:31634 ! Dengue virus 2 Thailand/16681/84 intersection_of: PR:000036837 ! prM relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine [Term] id: PR:000044758 name: NS1 (Dengue virus 2 Thailand/NGS-C/1944) def: "An NS1 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 776-1127, Asn-905/Asn-982, MOD:00160." [PRO:DNx] comment: Category=organism-modification. synonym: "NS1 (DEN2N)" EXACT PRO-short-label [PRO:DAN] synonym: "PRO_0000037962, Asn-905/Asn-982, MOD:00160" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P14340, 776-1127, Asn-905/Asn-982, MOD:00160" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:11065 ! Dengue virus 2 Thailand/NGS-C/1944 intersection_of: PR:000036824 ! NS1 relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine [Term] id: PR:Q5UB51 name: genome polyprotein (Dengue virus 3 Singapore/8120/1995) def: "A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 3 Singapore/8120/1995." [PRO:ES] comment: Category=organism-gene. synonym: "polyprot (DEN3I)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q5UB51 intersection_of: only_in_taxon NCBITaxon:408693 ! Dengue virus 3 Singapore/8120/1995 intersection_of: PR:000036816 ! dengue virus genome polyprotein [Term] id: PR:P33478 name: genome polyprotein (Dengue virus 1 Singapore/S275/1990) def: "A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 1 Singapore/S275/1990." [PRO:ES] comment: Category=organism-gene. synonym: "polyprot (DEN1S)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P33478 intersection_of: only_in_taxon NCBITaxon:33741 ! Dengue virus 1 Singapore/S275/1990 intersection_of: PR:000036816 ! dengue virus genome polyprotein [Term] id: PR:000044759 name: NS2A (Dengue virus 2 Thailand/NGS-C/1944) def: "An NS2A in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1128-1345." [PRO:DNx] comment: Category=organism-modification. synonym: "NS2A (DEN2N)" EXACT PRO-short-label [PRO:DAN] synonym: "PRO_0000037963" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P14340, 1128-1345" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:11065 ! Dengue virus 2 Thailand/NGS-C/1944 intersection_of: PR:000036825 ! NS2A [Term] id: PR:000044761 name: NS2B (Dengue virus 2 Thailand/NGS-C/1944) def: "An NS2B in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1346-1475." [PRO:DNx] comment: Category=organism-modification. synonym: "NS2B (DEN2N)" EXACT PRO-short-label [PRO:DAN] synonym: "PRO_0000037964" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P14340, 1346-1475" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:11065 ! Dengue virus 2 Thailand/NGS-C/1944 intersection_of: PR:000036827 ! NS2B [Term] id: PR:000044760 name: NS2A (Dengue virus 2 Thailand/16681/84) def: "An NS2A in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 1128-1345." [PRO:DNx] comment: Category=organism-modification. synonym: "NS2A (DEN26)" EXACT PRO-short-label [PRO:DAN] synonym: "PRO_0000037930" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P29990, 1128-1345" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:31634 ! Dengue virus 2 Thailand/16681/84 intersection_of: PR:000036825 ! NS2A [Term] id: PR:000044763 name: NS4A (Dengue virus 2 Thailand/NGS-C/1944) def: "An NS4A in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2094-2220." [PRO:DNx] comment: Category=organism-modification. synonym: "NS4A (DEN2N)" EXACT PRO-short-label [PRO:DAN] synonym: "PRO_0000037966" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P14340, 2094-2220" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:11065 ! Dengue virus 2 Thailand/NGS-C/1944 intersection_of: PR:000036830 ! NS4A [Term] id: PR:000044762 name: NS3 (Dengue virus 2 Thailand/NGS-C/1944) def: "An NS3 in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 1476-2093." [PRO:DNx] comment: Category=organism-modification. synonym: "NS3 (DEN2N)" EXACT PRO-short-label [PRO:DAN] synonym: "PRO_0000037965" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P14340, 1476-2093" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:11065 ! Dengue virus 2 Thailand/NGS-C/1944 intersection_of: PR:000036828 ! NS3 [Term] id: PR:000044765 name: 2K (Dengue virus 2 Thailand/NGS-C/1944) def: "A 2K in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2221-2243." [PRO:DNx] comment: Category=organism-modification. synonym: "2K (DEN2N)" EXACT PRO-short-label [PRO:DAN] synonym: "PRO_0000261391" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P14340, 2221-2243" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:11065 ! Dengue virus 2 Thailand/NGS-C/1944 intersection_of: PR:000036831 ! 2K [Term] id: PR:000037000 name: NS1, with complex sugar attached def: "An NS1 that has had the glycan attached to the Asn-130 site modified to a complex sugar." [PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "DenV-NS1/sugar(+)" EXACT PRO-short-label [PRO:DAN] is_a: PR:000036824 ! NS1 [Term] id: PR:000044767 name: NS4B (Dengue virus 2 Thailand/16681/84) def: "An NS4B in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 2244-2491." [PRO:DNx] comment: Category=organism-modification. synonym: "NS4B (DEN26)" EXACT PRO-short-label [PRO:DAN] synonym: "PRO_0000037934" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P29990, 2244-2491" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:31634 ! Dengue virus 2 Thailand/16681/84 intersection_of: PR:000036833 ! NS4B [Term] id: PR:000044766 name: NS4B (Dengue virus 2 Thailand/NGS-C/1944) def: "An NS4B in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 2244-2491." [PRO:DNx] comment: Category=organism-modification. synonym: "NS4B (DEN2N)" EXACT PRO-short-label [PRO:DAN] synonym: "PRO_0000037967" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P14340, 2244-2491" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:11065 ! Dengue virus 2 Thailand/NGS-C/1944 intersection_of: PR:000036833 ! NS4B [Term] id: PR:000037001 name: NS1, without complex sugar attached def: "An NS1 that has not had the glycan attached to the Asn-130 site modified to a complex sugar." [PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "DenV-NS1/sugar(-)" EXACT PRO-short-label [PRO:DAN] is_a: PR:000036824 ! NS1 [Term] id: PR:P14340 name: genome polyprotein (Dengue virus 2 Thailand/NGS-C/1944) def: "A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 Thailand/NGS-C/1944." [PRO:ES] comment: Category=organism-gene. synonym: "polyprot (DEN2N)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P14340 intersection_of: only_in_taxon NCBITaxon:11065 ! Dengue virus 2 Thailand/NGS-C/1944 intersection_of: PR:000036816 ! dengue virus genome polyprotein [Term] id: PR:000036998 name: NS1-NS2A def: "A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS12345 consisting of NS1 and NS2A. It includes two N-glycosylated residues at Asn-130 and Asn-207. Example: UniProtKB:P29990, 776-1345, Asn-905/Asn-982, MOD:00160." [PMID:15592895, PRO:DAN, PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "DenV-NS12A" EXACT PRO-short-label [PRO:DAN] intersection_of: has_part MOD:00160 ! N4-glycosyl-L-asparagine intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: has_part PR:000036824 ! NS1 intersection_of: has_part PR:000036825 ! NS2A intersection_of: lacks_part PR:000036827 ! NS2B intersection_of: lacks_part PR:000036828 ! NS3 intersection_of: lacks_part PR:000036830 ! NS4A intersection_of: lacks_part PR:000036831 ! 2K intersection_of: lacks_part PR:000036833 ! NS4B intersection_of: lacks_part PR:000036835 ! NS5 intersection_of: derives_from PR:000036838 ! NS12345 [Term] id: PR:000036818 name: dengue virus genome polyprotein proteolytic cleavage product def: "A dengue virus genome polyprotein, N-glycosylated form that has been processed by proteolytic cleavage." [PRO:DAN, PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "DenV-polyprot/ClvPrd" EXACT PRO-short-label [PRO:DAN] intersection_of: output_of GO:0016485 ! protein processing intersection_of: PR:000036817 ! dengue virus genome polyprotein, N-glycosylated form [Term] id: PR:000036819 name: capsid protein C def: "A dengue virus genome polyprotein proteolytic cleavage product that is a structural protein processed at the N-terminal end of the dengue virus RNA genome." [PRO:ES] comment: Category=modification. Requested by=IDODEN. Capsid protein C is a highly basic alpha-helical protein of about 100 amino acid residues that forms an emphipathic homodimer to encapsidate the viral genome and to interact with viral membranes [PMID:23673222, PRO:ES]. synonym: "anchC" EXACT [] synonym: "DenV-C" EXACT PRO-short-label [PRO:DAN] synonym: "anchored C" EXACT [] synonym: "core protein" EXACT [] intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: lacks_part PR:000036820 ! pr protein intersection_of: lacks_part PR:000036821 ! M protein intersection_of: derives_from PR:000036836 ! C-prM [Term] id: PR:000036838 name: NS12345 def: "A dengue virus genome polyprotein proteolytic cleavage product that is derived from dengue virus genome polyprotein, N-glycosylated form and that contains the entire non-structural region of the dengue virus genome polyprotein only and is responsible for directing viral genomic RNA replication, including synthesizing negative- and positive-strand RNAs and forming the viral RNA cap structure. It consists of NS1, NS2A, NS3, NS4A, 2K, NS4B, and NS5." [PMID:1433530, PMID:22022449, PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "DenV-NS12345" EXACT PRO-short-label [PRO:DAN] synonym: "Nonstructural proteins" EXACT [] synonym: "Non-structural proteins" EXACT [] synonym: "NS1-NS2A-NS2B-NS3-NS4A-NS4B-NS5" EXACT [] intersection_of: derives_from PR:000036817 ! dengue virus genome polyprotein, N-glycosylated form intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: lacks_part PR:000036822 ! E protein intersection_of: has_part PR:000036824 ! NS1 intersection_of: has_part PR:000036825 ! NS2A intersection_of: has_part PR:000036827 ! NS2B intersection_of: has_part PR:000036828 ! NS3 intersection_of: has_part PR:000036830 ! NS4A intersection_of: has_part PR:000036831 ! 2K intersection_of: has_part PR:000036833 ! NS4B intersection_of: has_part PR:000036835 ! NS5 intersection_of: lacks_part PR:000036836 ! C-prM [Term] id: PR:000036839 name: NS345 def: "A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS12345 by the two-component proteinase NS2B-NS3 at the NS2B-NS3 site consisting of NS3, NS4A, NS4B, and NS5." [PMID:1433530, PRO:ES] comment: Category=modification. Requested by=IDODEN. Cleavage at the NS2A-NS2B site was also mediated by the NS2B-NS3 protease, while the NS1-NS2A site was mediated by host cell-derived protease. synonym: "DenV-NS345" EXACT PRO-short-label [PRO:DAN] synonym: "NS3-NS4A-NS4B-NS5" EXACT [] intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: lacks_part PR:000036824 ! NS1 intersection_of: lacks_part PR:000036825 ! NS2A intersection_of: lacks_part PR:000036826 ! NS2A-alpha intersection_of: lacks_part PR:000036827 ! NS2B intersection_of: has_part PR:000036828 ! NS3 intersection_of: has_part PR:000036830 ! NS4A intersection_of: has_part PR:000036831 ! 2K intersection_of: has_part PR:000036833 ! NS4B intersection_of: has_part PR:000036835 ! NS5 intersection_of: derives_from PR:000036838 ! NS12345 [Term] id: PR:Q2YHF0 name: genome polyprotein (Dengue virus 4 Thailand/0348/1991) def: "A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 4 Thailand/0348/1991." [PRO:ES] comment: Category=organism-gene. synonym: "polyprot (DEN4T)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q2YHF0 intersection_of: only_in_taxon NCBITaxon:408688 ! Dengue virus 4 Thailand/0348/1991 intersection_of: PR:000036816 ! dengue virus genome polyprotein [Term] id: PR:000036834 name: precursor of NS5 def: "A dengue virus genome polyprotein proteolytic cleavage product that is a precursor of NS5." [PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "DenV-preNS5" EXACT PRO-short-label [PRO:DAN] is_a: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product union_of: PR:000036840 ! NS4A-NS4B-NS5 union_of: PR:000036843 ! NS4B-NS5 [Term] id: PR:000036835 name: NS5 def: "A dengue virus genome polyprotein proteolytic cleavage product that is a large non-structural protein encoded by the dengue virus RNA genome containing a methyltransferase (MTase) domain and an RNA dependent RNA polymerase (POL) domain that possesses a capping enzyme." [PMID:22022449, PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "DenV-NS5" EXACT PRO-short-label [PRO:DAN] synonym: "RdRp NS5" EXACT [] synonym: "Non-structural protein 5" EXACT [] synonym: "RNA directed RNA polymerase NS5" EXACT [] intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: lacks_part PR:000036830 ! NS4A intersection_of: lacks_part PR:000036831 ! 2K intersection_of: lacks_part PR:000036833 ! NS4B intersection_of: derives_from PR:000036834 ! precursor of NS5 [Term] id: PR:000036836 name: C-prM def: "A dengue virus genome polyprotein proteolytic cleavage product that is derived from dengue virus genome polyprotein, glycosylated form and that consists only of the C (capsid) protein and the prM (pre-membrane) structural proteins of the dengue virus genome polyprotein. It has a single N-linked glycosylation site at position Asn-69. Example: UniProtKB:P29990, 1-280, Asn-183, MOD:00160." [PMID:14963133, PRO:DAN, PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "CprM" EXACT [] synonym: "DenV-CprM" EXACT PRO-short-label [PRO:DAN] intersection_of: has_part MOD:00160 ! N4-glycosyl-L-asparagine intersection_of: derives_from PR:000036817 ! dengue virus genome polyprotein, N-glycosylated form intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: has_part PR:000036819 ! capsid protein C intersection_of: has_part PR:000036837 ! prM intersection_of: lacks_part PR:000036838 ! NS12345 [Term] id: PR:000036837 name: prM def: "A dengue virus genome polyprotein proteolytic cleavage product that is a product of the cleavage of C-prM by host signalase. It has a single N-linked glycosylation site at position Asn-69. Example: UniProtKB:P29990, 115-280, Asn-183, MOD:00160." [PMID:14963133, PRO:DAN, PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "preM" EXACT [] synonym: "DenV-prM" EXACT PRO-short-label [PRO:DAN] intersection_of: has_part MOD:00160 ! N4-glycosyl-L-asparagine intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: lacks_part PR:000036819 ! capsid protein C intersection_of: has_part PR:000036820 ! pr protein intersection_of: has_part PR:000036821 ! M protein intersection_of: derives_from PR:000036836 ! C-prM [Term] id: PR:000036830 name: NS4A def: "A dengue virus genome polyprotein proteolytic cleavage product that is a highly hydrophobic non-structural protein encoded by the dengue virus RNA genome that associates with membranes via 4 internal hydrophobic regions which are all able to mediate membrane targeting of a cytosolic reporter protein." [PMID:17276984, PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "DenV-NS4A" EXACT PRO-short-label [PRO:DAN] synonym: "Non-structural protein 4A" EXACT [] intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: lacks_part PR:000036831 ! 2K intersection_of: lacks_part PR:000036833 ! NS4B intersection_of: derives_from PR:000036841 ! NS4AB [Term] id: PR:000036831 name: 2K def: "A dengue virus genome polyprotein proteolytic cleavage product that is the C-terminal region of NS4A serving as a signal sequence for the translocation of the adjacent NS4B into the endoplasmic reticulum (ER) lumen." [PMID:17276984, PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "DenV-2K" EXACT PRO-short-label [PRO:DAN] synonym: "Peptide 2K" EXACT [] synonym: "2K fragment" EXACT [] intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: lacks_part PR:000036833 ! NS4B intersection_of: derives_from PR:000036842 ! 2KNS4B [Term] id: PR:000036832 name: precursor of NS4B def: "A dengue virus genome polyprotein proteolytic cleavage product that is a precursor of NS4B." [PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "DenV-preNS4B" EXACT PRO-short-label [PRO:DAN] is_a: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product union_of: PR:000036841 ! NS4AB union_of: PR:000036843 ! NS4B-NS5 [Term] id: PR:000036833 name: NS4B def: "A dengue virus genome polyprotein proteolytic cleavage product that is a highly hydrophobic transmembrane non-structural protein encoded by the dengue virus RNA genome which is, in part, responsible for the membrane arrangements leading to the formation of the viral replication complex." [PMID:22772157, PRO:ES] comment: Category=modification. Requested by=IDODEN. synonym: "DenV-NS4B" EXACT PRO-short-label [PRO:DAN] synonym: "Non-structural protein 4B" EXACT [] intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: lacks_part PR:000036830 ! NS4A intersection_of: lacks_part PR:000036831 ! 2K intersection_of: derives_from PR:000036832 ! precursor of NS4B intersection_of: lacks_part PR:000036835 ! NS5 [Term] id: PR:Q58HT7 name: genome polyprotein (Dengue virus 4 Philippines/H241/1956) def: "A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 4 Philippines/H241/1956." [PRO:ES] comment: Category=organism-gene. synonym: "polyprot (DEN4P)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q58HT7 intersection_of: only_in_taxon NCBITaxon:408686 ! Dengue virus 4 Philippines/H241/1956 intersection_of: PR:000036816 ! dengue virus genome polyprotein [Term] id: PR:P07564 name: genome polyprotein (Dengue virus 2 Jamaica/1409/1983) def: "A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 Jamaica/1409/1983." [PRO:ES] comment: Category=organism-gene. synonym: "polyprot (DEN2J)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P07564 intersection_of: only_in_taxon NCBITaxon:11064 ! Dengue virus 2 Jamaica/1409/1983 intersection_of: PR:000036816 ! dengue virus genome polyprotein [Term] id: PR:P14337 name: genome polyprotein (Dengue virus 2 Thailand/0168/1979) def: "A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 Thailand/0168/1979." [PRO:ES] comment: Category=organism-gene. synonym: "polyprot (DEN28)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P14337 intersection_of: only_in_taxon NCBITaxon:413041 ! Dengue virus 2 Thailand/0168/1979 intersection_of: PR:000036816 ! dengue virus genome polyprotein [Term] id: PR:000044764 name: NS4A (Dengue virus 2 Thailand/16681/84) def: "An NS4A in Dengue virus 2 Thailand/16681/84. UniProtKB:P29990, 2094-2220." [PRO:DNx] comment: Category=organism-modification. synonym: "NS4A (DEN26)" EXACT PRO-short-label [PRO:DAN] synonym: "PRO_0000037933" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P29990, 2094-2220" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:31634 ! Dengue virus 2 Thailand/16681/84 intersection_of: PR:000036830 ! NS4A [Term] id: PR:000036873 name: NS2B-NS3 polyprotein precursor def: "A dengue virus genome polyprotein proteolytic cleavage product that is cleaved from NS12345 by the two-component protease NS2B-NS3 at the NS2A-NS2B and NS3-NS4 sites and consists of NS2B and NS3." [PMID:10744671, PRO:ES] comment: Category=modification. Requested by=IDODEN. Analysis of polyprotein processing in vivo established that the NS3 protease, as a heterodimeric complex with the viral activator protein NS2B, catalyzes the cis cleavage of NS2A-NS2B and NS2B-NS3, as well as the trans cleavage of NS3-NS4A and NS4B-NS5 sites in the polyprotein. [PMID:10744671, PRO:ES] synonym: "DenV-NS2B3" EXACT PRO-short-label [PRO:DAN] intersection_of: PR:000036818 ! dengue virus genome polyprotein proteolytic cleavage product intersection_of: lacks_part PR:000036824 ! NS1 intersection_of: lacks_part PR:000036825 ! NS2A intersection_of: lacks_part PR:000036826 ! NS2A-alpha intersection_of: has_part PR:000036827 ! NS2B intersection_of: has_part PR:000036828 ! NS3 intersection_of: lacks_part PR:000036830 ! NS4A intersection_of: lacks_part PR:000036831 ! 2K intersection_of: lacks_part PR:000036833 ! NS4B intersection_of: lacks_part PR:000036835 ! NS5 intersection_of: derives_from PR:000036838 ! NS12345 [Term] id: PR:P09866 name: genome polyprotein (Dengue virus 4 Dominica/814669/1981) def: "A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 4 Dominica/814669/1981." [PRO:ES] comment: Category=organism-gene. synonym: "polyprot" RELATED Gene-based [UniProtKB:P09866] synonym: "polyprot (DEN4D)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P09866 intersection_of: only_in_taxon NCBITaxon:408871 ! Dengue virus 4 Dominica/814669/1981 intersection_of: PR:000036816 ! dengue virus genome polyprotein relationship: has_gene_template NCBIGene:5075729 ! polyprot (Dengue virus 4 Dominica/814669/1981) [Term] id: PR:P27915 name: genome polyprotein (Dengue virus 3 Philippines/H87/1956) def: "A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 3 Philippines/H87/1956." [PRO:ES] comment: Category=organism-gene. synonym: "polyprot (DEN3P)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P27915 intersection_of: only_in_taxon NCBITaxon:408870 ! Dengue virus 3 Philippines/H87/1956 intersection_of: PR:000036816 ! dengue virus genome polyprotein [Term] id: PR:P12823 name: genome polyprotein (Dengue virus 2 Puerto Rico/PR159-S1/1969) def: "A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 2 Puerto Rico/PR159-S1/1969." [PRO:ES] comment: Category=organism-gene. synonym: "polyprot (DEN2P)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P12823 intersection_of: only_in_taxon NCBITaxon:11066 ! Dengue virus 2 Puerto Rico/PR159-S1/1969 intersection_of: PR:000036816 ! dengue virus genome polyprotein [Term] id: PR:Q6YMS4 name: genome polyprotein (Dengue virus 3 Sri Lanka/1266/2000) def: "A dengue virus genome polyprotein that is encoded in the genome of Dengue virus 3 Sri Lanka/1266/2000." [PRO:ES] comment: Category=organism-gene. synonym: "pol" RELATED Gene-based [UniProtKB:Q6YMS4] synonym: "polyprot (DEN3S)" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q6YMS4 intersection_of: only_in_taxon NCBITaxon:408692 ! Dengue virus 3 Sri Lanka/1266/2000 intersection_of: PR:000036816 ! dengue virus genome polyprotein relationship: has_gene_template NCBIGene:5075727 ! polyprot (Dengue virus 3 Sri Lanka/1266/2000) [Term] id: PR:000044770 name: prM (Dengue virus 2 Thailand/NGS-C/1944) def: "A prM in Dengue virus 2 Thailand/NGS-C/1944. UniProtKB:P14340, 115-280, Asn-183, MOD:00160." [PRO:DNx] comment: Category=organism-modification. synonym: "prM (DEN2N)" EXACT PRO-short-label [PRO:DAN] synonym: "PRO_0000261389, Asn-183, MOD:00160" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P14340, 115-280, Asn-183, MOD:00160" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:11065 ! Dengue virus 2 Thailand/NGS-C/1944 intersection_of: PR:000036837 ! prM relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine