[Term]
id: PR:000050286
name: proofreading exoribonuclease nsp14 (SARS-CoV-2)
def: "An ORF1ab proteolytic cleavage product (SARS-CoV-2) that is the central portion produced by the enzymatic action of 3CL-PRO proteinase (nsp5) when it cleaves the precursor replicase polyprotein 1ab (SARS-CoV-2) between residues 5925-5926 and 6452-6453. UniProtKB:P0DTD1, 4393-5324." [GenPept:YP_009725309, PRO:DAN, UniProtKB:P0DTD1]
comment: Category=organism-modification. Note: 527 aa protein.
synonym: "PRO_0000449631" EXACT PRO-proteoform-ftid [PRO:DAN]
synonym: "ExoN (SARS-CoV-2)" EXACT [UniProtKB:P0DTD1]
synonym: "nsp14 (SARS-CoV-2)" EXACT [UniProtKB:P0DTD1]
synonym: "ORF1ab/Clv:nsp14 (SARS2)" EXACT PRO-short-label [PRO:DAN]
synonym: "UniProtKB:P0DTD1, 5926-6452" EXACT PRO-proteoform-std [PRO:DAN]
synonym: "3'-to-5' exonuclease (SARS2)" NARROW [GenPept:YP_009725309]
synonym: "guanine-N7 methyltransferase (SARS2)" NARROW [UniProtKB:P0DTD1]
xref: GenPept:YP_009725309
is_a: PR:000050283 ! ORF1ab proteolytic cleavage product (SARS-CoV-2)
relationship: only_in_taxon NCBITaxon:2697049 ! Severe acute respiratory syndrome coronavirus 2