[Term]
id: PR:000000019
name: mitogen-activated protein kinase
def: "A protein that is a serine/threonine-specific protein kinase that responds to extracellular stimuli (mitogens) and regulates cellular activities such as gene expression, mitosis, differentiation, and cell survival/apoptosis. The activated form phosphorylates target substrates on Ser or Thr residues followed by a proline. A distinguishing feature is the conserved sequence TxY." [PRO:CNA, Wikipedia:Mitogen-activated_protein_kinase]
comment: Category=family.
synonym: "MAPK" EXACT []
synonym: "kinase-related transforming protein" RELATED []
xref: PIRSF:PIRSF501110
is_a: PR:000000001 ! protein