[Term] id: PR:P36897-1 name: TGF-beta receptor type-1 isoform 1 (human) def: "A TGF-beta receptor type-1 isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. Requested by=PubChem. synonym: "hTGFBR1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P36897-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000185 ! TGF-beta receptor type-1 isoform 1 [Term] id: PR:000000195 name: TGF-beta receptor type-1 sequence variant R487E (human) def: "A TGF-beta receptor type-1 (human) that has a Glu residue at the position equivalent to Arg-487 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Arg-487, CHEBI:29972." [PMID:16791849, PMID:16928994, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hTGFBR1/var:R487E" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P36897-1, Arg-487, CHEBI:29972" NARROW PRO-proteoform-std [PRO:DAN] synonym: "TGF-beta receptor type-1 sequence variant 8 (human)" EXACT [PRO:DNx] xref: UniProtKB_VAR:VAR_029484 is_a: PR:P36897 ! TGF-beta receptor type-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P36897 name: TGF-beta receptor type-1 (human) def: "A TGF-beta receptor type-1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P36897] comment: Category=organism-gene. synonym: "ALK5" RELATED Gene-based [UniProtKB:P36897] synonym: "SKR4" RELATED Gene-based [UniProtKB:P36897] synonym: "TGFBR1" RELATED Gene-based [UniProtKB:P36897] synonym: "hTGFBR1" EXACT PRO-short-label [PRO:DNx] synonym: "ALK-5 (human)" EXACT [UniProtKB:P36897] synonym: "TGFR-1 (human)" EXACT [UniProtKB:P36897] synonym: "TbetaR-I (human)" EXACT [UniProtKB:P36897] synonym: "TGF-beta receptor type I (human)" EXACT [UniProtKB:P36897] synonym: "TGF-beta type I receptor (human)" EXACT [UniProtKB:P36897] synonym: "activin receptor-like kinase 5 (human)" EXACT [UniProtKB:P36897] synonym: "serine/threonine-protein kinase receptor R4 (human)" EXACT [UniProtKB:P36897] synonym: "transforming growth factor-beta receptor type I (human)" EXACT [UniProtKB:P36897] synonym: "activin A receptor type II-like protein kinase of 53kD (human)" EXACT [UniProtKB:P36897] xref: DTO:03100523 xref: UniProtKB:P36897 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000047 ! TGF-beta receptor type-1 relationship: has_gene_template HGNC:11772 ! TGFBR1 (human) [Term] id: PR:000025959 name: TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 (human) def: "A TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 in human. Phosphorylation occurs by the action of active TGF-beta receptor type-2 within the GS-motifs. UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047." [PMID:7774578, PMID:8947046] comment: Category=organism-modification. Kinase=("TGFBR2"; PR:000025962; Ser-165/Thr-185/Thr-186/Ser-187/Ser-189/Ser-191). synonym: "hTGFBR1/iso:1/SigPep-/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000024423, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P36897-1, 34-503, Ser-165/Ser-187/Ser-189/Ser-191, MOD:00046|Thr-185/Thr-186, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-170849 "PR:000025959 located_in GO:0005886" intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000523 ! TGF-beta receptor type-1 isoform 1, signal peptide removed phosphorylated 1 relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000049433 name: TGF-beta receptor type-1, signal peptide removed ubiquitinated form (human) def: "A TGF-beta receptor type-1 (human) that has had the signal peptide removed and that includes at least one ubiquitinated lysine. UniProtKB:P36897, 34-503, MOD:01148." [PRO:DNx, Reactome:R-HSA-8869461] comment: Category=organism-modification. synonym: "hTGFBR1/SigPep-/UbiqLys+" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000024423, MOD:01148" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P36897, 34-503, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-8869461 "PR:000049433 located_in GO:0005886" intersection_of: has_part MOD:01148 ! ubiquitinylated lysine intersection_of: PR:P36897 ! TGF-beta receptor type-1 (human) intersection_of: lacks_part SO:0000418 ! signal_peptide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P36897-3 name: TGF-beta receptor type-1 isoform h3 (human) def: "A TGF-beta receptor type-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36897-3." [PRO:DNx, UniProtKB:P36897] comment: Category=organism-sequence. synonym: "hTGFBR1/iso:h3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P36897-3 is_a: PR:P36897 ! TGF-beta receptor type-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000189 name: TGF-beta receptor type-1 sequence variant K232E (human) def: "A TGF-beta receptor type-1 (human) that has a Glu residue at the position equivalent to Lys-232 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Lys-232, CHEBI:29972." [PMID:16928994, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hTGFBR1/var:K232E" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P36897-1, Lys-232, CHEBI:29972" NARROW PRO-proteoform-std [PRO:DAN] synonym: "TGF-beta receptor type-1 sequence variant 2 (human)" EXACT [PRO:DNx] xref: UniProtKB_VAR:VAR_029481 is_a: PR:P36897 ! TGF-beta receptor type-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000188 name: TGF-beta receptor type-1 sequence variant 11 (human) def: "A TGF-beta receptor type-1 (human) that has a three-residue deletion at the position equivalent to region 24-26 of the amino acid sequence represented by UniProtKB:P36897-1. UniProtKB:P36897, 1-23, 27-503." [PRO:CNA, PRO:DAN] comment: Category=organism-sequence. Note: This deletion is within the signal peptide. synonym: "hTGFBR1/var:11" EXACT PRO-short-label [PRO:DNx] synonym: "TGFBR1*6A (human)" RELATED [] synonym: "UniProtKB:P36897, 1-23, 27-503" EXACT PRO-proteoform-std [PRO:DAN] synonym: "UniProtKB:P36897-1, 1-23, 27-503" NARROW PRO-proteoform-std [PRO:DAN] is_a: PR:P36897 ! TGF-beta receptor type-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000036432 name: TGF-beta receptor type-1 isoform 1, signal peptide removed form (human) def: "A TGF-beta receptor type-1 isoform 1, signal peptide removed form in human. UniProtKB:P36897-1, 25-503." [PMID:8242743, PRO:CNA] comment: Category=organism-modification. synonym: "hTGFBR1/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P36897-1, 25-503" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000522 ! TGF-beta receptor type-1 isoform 1, signal peptide removed form [Term] id: PR:000000047 name: TGF-beta receptor type-1 def: "A TGF-beta superfamily receptor type-1 that is a translation product of the human TGFBR1 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "ALK5" RELATED Gene-based [] synonym: "ESK2" EXACT [] synonym: "SKR4" RELATED Gene-based [] synonym: "ALK-5" EXACT [] synonym: "TGFBR1" EXACT PRO-short-label [PRO:DNx] synonym: "TGFR-1" BROAD [] synonym: "TbetaR-I" BROAD [] synonym: "TGF-beta receptor type I" BROAD [] synonym: "TGF-beta type I receptor" BROAD [] synonym: "activin receptor-like kinase 5" EXACT [] synonym: "serine/threonine-protein kinase receptor R4" EXACT [] synonym: "transforming growth factor-beta receptor type I" BROAD [] xref: IUPHARobj:1788 is_a: PR:000000006 ! TGF-beta superfamily receptor type-1 [Term] id: PR:000049432 name: TGF-beta receptor type-1, signal peptide removed form (human) def: "A TGF-beta receptor type-1 (human) that has had the signal peptide removed. UniProtKB:P36897, 34-503." [PRO:DNx, Reactome:R-HSA-170839] comment: Category=organism-modification. synonym: "PRO_0000024423" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hTGFBR1/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P36897, 34-503" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-170839 "PR:000049432 located_in GO:0005886" intersection_of: PR:P36897 ! TGF-beta receptor type-1 (human) intersection_of: lacks_part SO:0000418 ! signal_peptide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000187 name: TGF-beta receptor type-1 sequence variant 10 (human) def: "A TGF-beta receptor type-1 (human) that has an insertion of an Ala residue at the position equivalent to Ala-26 of the amino acid sequence represented by UniProtKB:P36897." [PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "TGFBR1*10A" RELATED [] synonym: "hTGFBR1/var:10" EXACT PRO-short-label [PRO:DNx] is_a: PR:P36897 ! TGF-beta receptor type-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P36897-2 name: TGF-beta receptor type-1 isoform h2 (human) def: "A TGF-beta receptor type-1 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P36897-2." [PRO:DNx, UniProtKB:P36897] comment: Category=organism-sequence. synonym: "hTGFBR1/iso:h2" EXACT PRO-short-label [PRO:DNx] synonym: "TGF-beta receptor type-1 isoform B (human)" EXACT [UniProtKB:P36897] xref: UniProtKB:P36897-2 is_a: PR:P36897 ! TGF-beta receptor type-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000196 name: TGF-beta receptor type-1 sequence variant R487W (human) def: "A TGF-beta receptor type-1 (human) that has a Trp residue at the position equivalent to Arg-487 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Arg-487, CHEBI:29954." [PMID:16928994, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hTGFBR1/var:R487W" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P36897-1, Arg-487, CHEBI:29954" NARROW PRO-proteoform-std [PRO:DAN] synonym: "TGF-beta receptor type-1 sequence variant 9 (human)" EXACT [PRO:DNx] xref: UniProtKB_VAR:VAR_029485 is_a: PR:P36897 ! TGF-beta receptor type-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000194 name: TGF-beta receptor type-1 sequence variant R487P (human) def: "A TGF-beta receptor type-1 (human) that has a Pro residue at the position equivalent to Arg-487 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Arg-487, CHEBI:50342." [PMID:15731757, PMID:16928994, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hTGFBR1/var:R487P" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P36897-1, Arg-487, CHEBI:50342" NARROW PRO-proteoform-std [PRO:DAN] synonym: "TGF-beta receptor type-1 sequence variant 7 (human)" EXACT [PRO:DNx] xref: UniProtKB_VAR:VAR_022347 is_a: PR:P36897 ! TGF-beta receptor type-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000191 name: TGF-beta receptor type-1 sequence variant N267H (human) def: "A TGF-beta receptor type-1 (human) that has a His residue at the position equivalent to Asn-267 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Asn-267, CHEBI:29979." [PMID:16791849, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hTGFBR1/var:N267H" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P36897-1, Asn-267, CHEBI:29979" NARROW PRO-proteoform-std [PRO:DAN] synonym: "TGF-beta receptor type-1 sequence variant 4 (human)" EXACT [PRO:DNx] xref: UniProtKB_VAR:VAR_029483 is_a: PR:P36897 ! TGF-beta receptor type-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000192 name: TGF-beta receptor type-1 sequence variant M318R (human) def: "A TGF-beta receptor type-1 (human) that has an Arg residue at the position equivalent to Met-318 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Met-318, CHEBI:29952." [PMID:15731757, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hTGFBR1/var:M318R" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P36897-1, Met-318, CHEBI:29952" NARROW PRO-proteoform-std [PRO:DAN] synonym: "TGF-beta receptor type-1 sequence variant 5 (human)" EXACT [PRO:DNx] xref: UniProtKB_VAR:VAR_022345 is_a: PR:P36897 ! TGF-beta receptor type-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000193 name: TGF-beta receptor type-1 sequence variant D400G (human) def: "A TGF-beta receptor type-1 (human) that has a Gly residue at the position equivalent to Asp-400 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Asp-400, CHEBI:29947." [PMID:15731757, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hTGFBR1/var:D400G" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P36897-1, Asp-400, CHEBI:29947" NARROW PRO-proteoform-std [PRO:DAN] synonym: "TGF-beta receptor type-1 sequence variant 6 (human)" EXACT [PRO:DNx] xref: UniProtKB_VAR:VAR_022346 is_a: PR:P36897 ! TGF-beta receptor type-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000190 name: TGF-beta receptor type-1 sequence variant S241L (human) def: "A TGF-beta receptor type-1 (human) that has a Leu residue at the position equivalent to Ser-241 of the amino acid sequence represented by UniProtKB:P36897-1. Example: UniProtKB:P36897-1, Ser-241, CHEBI:30006." [PMID:16596670, PMID:16791849, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hTGFBR1/var:S241L" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P36897-1, Ser-241, CHEBI:30006" NARROW PRO-proteoform-std [PRO:DAN] synonym: "TGF-beta receptor type-1 sequence variant 3 (human)" EXACT [PRO:DNx] xref: UniProtKB_VAR:VAR_029482 is_a: PR:P36897 ! TGF-beta receptor type-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000186 name: TGF-beta receptor type-1 sequence variant T200I (human) def: "A TGF-beta receptor type-1 (human) that has an Ile residue at the position equivalent to Thr-200 of the amino acid sequence represented by UniProtKB:P36897. UniProtKB:P36897, Thr-200, CHEBI:30009." [PMID:15731757, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hTGFBR1/var:T200I" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P36897, Thr-200, CHEBI:30009" EXACT PRO-proteoform-std [PRO:DAN] synonym: "UniProtKB:P36897-1, Thr-200, CHEBI:30009" NARROW PRO-proteoform-std [PRO:DAN] synonym: "TGF-beta receptor type-1 sequence variant 1 (human)" EXACT [PRO:DNx] xref: UniProtKB_VAR:VAR_022344 is_a: PR:P36897 ! TGF-beta receptor type-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens