[Term] id: PR:Q64700 name: retinoblastoma-like protein 2 (mouse) def: "A retinoblastoma-like protein 2 that is encoded in the genome of mouse." [OMA:Q64700, PRO:DNx] comment: Category=organism-gene. synonym: "Rbl2" RELATED Gene-based [UniProtKB:Q64700] synonym: "mRBL2" EXACT PRO-short-label [PRO:DNx] synonym: "p130 (mouse)" BROAD [UniProtKB:Q64700] synonym: "pRb2 (mouse)" EXACT [UniProtKB:Q64700] synonym: "RBR-2 (mouse)" EXACT [UniProtKB:Q64700] synonym: "retinoblastoma-related protein 2 (mouse)" EXACT [UniProtKB:Q64700] synonym: "130 kDa retinoblastoma-associated protein (mouse)" EXACT [UniProtKB:Q64700] xref: UniProtKB:Q64700 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000119 ! retinoblastoma-like protein 2 relationship: has_gene_template MGI:105085 ! Rbl2 (mouse) [Term] id: PR:000000562 name: retinoblastoma-like protein 2 isoform 1 phosphorylated 3 def: "A retinoblastoma-like protein 2 isoform 1 that has been phosphorylated on residues at positions equivalent to Ser-639, Ser-952, Ser-966, Ser-971, Ser-972, Ser-973, Thr-974, Ser-981, Ser-982, and Thr-986 of the amino acid sequence represented by UniProtKB:Q08999-1 or a 1:1 ortholog thereof. Example: UniProtKB:Q08999-1, Ser-639/Ser-952/Ser-966/Ser-971/Ser-972/Ser-973/Ser-981/Ser-982, MOD:00046|Thr-974/Thr-986, MOD:00047." [PRO:CNA, PRO:DAN] comment: Category=modification. Note: This is the form observed in quiescent cells. synonym: "RBL2/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000306 ! retinoblastoma-like protein 2 isoform 1 relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000000561 name: retinoblastoma-like protein 2 isoform 1 phosphorylated 2 def: "A retinoblastoma-like protein 2 isoform 1 phosphorylated form that has Cdk-dependent G1 phosphorylation, and additionally phosphorylated on a Ser residue within the region linking the retinoblastoma-associated protein A and B domains, by cyclin Cdk4(6). This phosphorylation leads to ubiquitin-dependent proteolysis." [PMID:12006580, PMID:12435635] comment: Category=modification. synonym: "RBL2/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000459 ! retinoblastoma-like protein 2 isoform 1 phosphorylated form relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000000560 name: retinoblastoma-like protein 2 isoform 1 phosphorylated 1 def: "A retinoblastoma-like protein 2 isoform 1 phosphorylated form in which the phosphorylation occurs during Go/G1-S phase progression. Example: UniProtKB:Q08999-1, Thr-401/Thr-417/Thr-642/Thr-694/Thr-986/Thr-1097, MOD:00047|Ser-413/Ser-639/Ser-662/Ser-672/Ser-688/Ser-948/Ser-952/Ser-962/Ser-966/Ser-973/Ser-982/Ser-1035/Ser-1044/Ser-1068/Ser-1080/Ser-1112, MOD:00046." [PRO:CNA, PRO:DAN] comment: Category=modification. synonym: "RBL2/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000459 ! retinoblastoma-like protein 2 isoform 1 phosphorylated form relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:Q08999-1 name: retinoblastoma-like protein 2 isoform 1 (human) def: "A retinoblastoma-like protein 2 isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hRBL2/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q08999-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000306 ! retinoblastoma-like protein 2 isoform 1 [Term] id: PR:Q08999-2 name: retinoblastoma-like protein 2 isoform h2 (human) def: "A retinoblastoma-like protein 2 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08999-2." [PRO:DNx, UniProtKB:Q08999] comment: Category=organism-sequence. synonym: "hRBL2/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q08999-2 is_a: PR:Q08999 ! retinoblastoma-like protein 2 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q08999 name: retinoblastoma-like protein 2 (human) def: "A retinoblastoma-like protein 2 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q08999] comment: Category=organism-gene. synonym: "RB2" RELATED Gene-based [UniProtKB:Q08999] synonym: "RBL2" RELATED Gene-based [UniProtKB:Q08999] synonym: "hRBL2" EXACT PRO-short-label [PRO:DNx] synonym: "p130 (human)" BROAD [UniProtKB:Q08999] synonym: "pRb2 (human)" EXACT [UniProtKB:Q08999] synonym: "RBR-2 (human)" EXACT [UniProtKB:Q08999] synonym: "retinoblastoma-related protein 2 (human)" EXACT [UniProtKB:Q08999] synonym: "130 kDa retinoblastoma-associated protein (human)" EXACT [UniProtKB:Q08999] xref: Reactome:R-HSA-389102 "PR:Q08999 located_in GO:0005654" xref: UniProtKB:Q08999 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000119 ! retinoblastoma-like protein 2 relationship: has_gene_template HGNC:9894 ! RBL2 (human) [Term] id: PR:000000459 name: retinoblastoma-like protein 2 isoform 1 phosphorylated form def: "A retinoblastoma-like protein 2 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA] comment: Category=modification. synonym: "RBL2/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx] intersection_of: has_part MOD:00696 ! phosphorylated residue intersection_of: PR:000000306 ! retinoblastoma-like protein 2 isoform 1 [Term] id: PR:000000119 name: retinoblastoma-like protein 2 def: "A retinoblastoma-like protein that is a translation product of the human RBL2 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "RB2" RELATED Gene-based [] synonym: "RBL2" EXACT PRO-short-label [PRO:DNx] synonym: "p130" BROAD [PRO:DNx] synonym: "pRb2" EXACT [] synonym: "RBR-2" EXACT [] synonym: "retinoblastoma-related protein 2" EXACT [] synonym: "130 kDa retinoblastoma-associated protein" EXACT [] is_a: PR:000000023 ! retinoblastoma-like protein [Term] id: PR:000049025 name: retinoblastoma-like protein 2 phosphorylated 4 (human) def: "A retinoblastoma-like protein 2 (human) that has been phosphorylated on the residue at the position equivalent to Thr-401, and phosphoserine at positions 672 and 1035 of the amino acid sequence represented by UniProtKB:Q08999. UniProtKB:Q08999, Thr-401, MOD:00047|Ser-672/Ser-1035, MOD:00046." [PRO:DNx, Reactome:R-HSA-1226084] comment: Category=organism-modification. synonym: "hRBL2/Phos:4" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q08999, Thr-401, MOD:00047|Ser-672/Ser-1035, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-1226084 "PR:000049025 located_in GO:0005654" is_a: PR:Q08999 ! retinoblastoma-like protein 2 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O55081 name: retinoblastoma-like protein 2 (rat) def: "A retinoblastoma-like protein 2 that is encoded in the genome of rat." [OMA:O55081, PANTHER:PTHR13742:SF8, PRO:DNx] comment: Category=organism-gene. synonym: "Rbl2" RELATED Gene-based [UniProtKB:O55081] synonym: "rRBL2" EXACT PRO-short-label [PRO:DNx] synonym: "p130 (rat)" BROAD [UniProtKB:O55081] synonym: "pRb2 (rat)" EXACT [UniProtKB:O55081] synonym: "RBR-2 (rat)" EXACT [UniProtKB:O55081] synonym: "PRIC128 (rat)" EXACT [UniProtKB:O55081] synonym: "retinoblastoma-related protein 2 (rat)" EXACT [UniProtKB:O55081] synonym: "130 kDa retinoblastoma-associated protein (rat)" EXACT [UniProtKB:O55081] synonym: "PPAR-alpha-interacting complex protein 128 (rat)" EXACT [UniProtKB:O55081] xref: UniProtKB:O55081 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000000119 ! retinoblastoma-like protein 2 relationship: has_gene_template RGD:3541 ! Rbl2 (rat) [Term] id: PR:000000306 name: retinoblastoma-like protein 2 isoform 1 def: "A retinoblastoma-like protein 2 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q08999-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] comment: Category=sequence. synonym: "RBL2/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000119 ! retinoblastoma-like protein 2 [Term] id: PR:000036474 name: retinoblastoma-like protein 2 isoform 1 phosphorylated 3 (mouse) def: "A retinoblastoma-like protein 2 isoform 1 phosphorylated 3 in mouse." [PMID:10082561, PRO:CNA] comment: Category=organism-modification. synonym: "mRBL2/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000562 ! retinoblastoma-like protein 2 isoform 1 phosphorylated 3 relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:Q64700-1 name: retinoblastoma-like protein 2 isoform 1 (mouse) def: "A retinoblastoma-like protein 2 isoform 1 that is encoded in the genome of mouse." [PRO:CNA] comment: Category=organism-sequence. synonym: "mRBL2/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q64700-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000306 ! retinoblastoma-like protein 2 isoform 1 [Term] id: PR:000036471 name: retinoblastoma-like protein 2 isoform 1 phosphorylated 1 (human) def: "A retinoblastoma-like protein 2 isoform 1 phosphorylated 1 in human. UniProtKB:Q08999-1, Thr-401/Thr-417/Thr-642/Thr-694/Thr-986/Thr-1097, MOD:00047|Ser-413/Ser-639/Ser-662/Ser-672/Ser-688/Ser-948/Ser-952/Ser-962/Ser-966/Ser-973/Ser-982/Ser-1035/Ser-1044/Ser-1068/Ser-1080/Ser-1112, MOD:00046." [PMID:11042701, PMID:11157749, PMID:8710362, PRO:CNA] comment: Category=organism-modification. synonym: "hRBL2/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q08999-1, Thr-401/Thr-417/Thr-642/Thr-694/Thr-986/Thr-1097, MOD:00047|Ser-413/Ser-639/Ser-662/Ser-672/Ser-688/Ser-948/Ser-952/Ser-962/Ser-966/Ser-973/Ser-982/Ser-1035/Ser-1044/Ser-1068/Ser-1080/Ser-1112, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000560 ! retinoblastoma-like protein 2 isoform 1 phosphorylated 1 relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000036472 name: retinoblastoma-like protein 2 isoform 1 phosphorylated 2 (human) def: "A retinoblastoma-like protein 2 isoform 1 phosphorylated 2 in human. UniProtKB:Q08999-1, Ser-672, MOD:00046." [PMID:12006580, PRO:CNA] comment: Category=organism-modification. synonym: "hRBL2/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q08999-1, Ser-672, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000561 ! retinoblastoma-like protein 2 isoform 1 phosphorylated 2 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000036473 name: retinoblastoma-like protein 2 isoform 1 phosphorylated 3 (human) def: "A retinoblastoma-like protein 2 isoform 1 phosphorylated 3 in human. UniProtKB:Q08999-1, Ser-639/Ser-952/Ser-966/Ser-971/Ser-972/Ser-973/Ser-981/Ser-982, MOD:00046|Thr-974/Thr-986, MOD:00047." [PMID:11042701, PMID:11157749, PMID:8710362, PRO:CNA] comment: Category=organism-modification. synonym: "hRBL2/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q08999-1, Ser-639/Ser-952/Ser-966/Ser-971/Ser-972/Ser-973/Ser-981/Ser-982, MOD:00046|Thr-974/Thr-986, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000562 ! retinoblastoma-like protein 2 isoform 1 phosphorylated 3 relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine