[Term] id: PR:000000563 name: Rho-associated protein kinase 1 isoform 1 cleaved 1 def: "A Rho-associated protein kinase 1 isoform 1 that has been processed by caspase-3 downstream the sequence motif DETD, removing the inhibitory C-terminus." [PMID:11283607, PMID:16983089] comment: Category=modification. Note: This form has been found significantly elevated in mouse myopathy model and human heart failure patients. synonym: "ROCK1/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx] synonym: "constitutively active ROCK-1" EXACT [] is_a: PR:000000307 ! Rho-associated protein kinase 1 isoform 1 relationship: output_of GO:0016485 ! protein processing [Term] id: PR:000018280 name: Rho-associated protein kinase 1, initiator methionine removed form def: "A Rho-associated protein kinase 1 that has had the initiator methionine removed." [PRO:DNx] comment: Category=modification. synonym: "ROCK1/InitMet-" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000000120 ! Rho-associated protein kinase 1 intersection_of: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:000026340 name: Rho-associated protein kinase 1 isoform 1 cleaved 1 (human) def: "A Rho-associated protein kinase 1 isoform 1 cleaved 1 in human. UniProtKB:Q13464-1, 1-1113." [PRO:DNx, UniProtKB:Q13464] comment: Category=organism-modification. synonym: "hROCK1/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q13464-1, 1-1113" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-212523 "PR:000026340 located_in GO:0005829" intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000563 ! Rho-associated protein kinase 1 isoform 1 cleaved 1 [Term] id: PR:000002529 name: Rho-associated protein kinase 1 isoform 1 unmodified form def: "A Rho-associated protein kinase 1 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx] comment: Category=modification. synonym: "ROCK1/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000000307 ! Rho-associated protein kinase 1 isoform 1 intersection_of: has_part PR:000021935 ! immature protein part intersection_of: lacks_part PR:000025513 ! modified amino-acid residue disjoint_from: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000025435 name: Rho-associated protein kinase 1 proteolytic cleavage product def: "A Rho-associated protein kinase 1 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "ROCK1/ClvPrd" EXACT PRO-short-label [PRO:DNx] intersection_of: output_of GO:0016485 ! protein processing intersection_of: PR:000000120 ! Rho-associated protein kinase 1 [Term] id: PR:000000120 name: Rho-associated protein kinase 1 def: "A Rho-associated protein kinase that is a translation product of the human ROCK1 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "ROCK1" EXACT PRO-short-label [PRO:DNx] synonym: "ROCK-I" EXACT [] synonym: "p160ROCK" EXACT [] synonym: "p160 ROCK-1" EXACT [] synonym: "renal carcinoma antigen NY-REN-35" EXACT [] synonym: "Rho-associated, coiled-coil-containing protein kinase I" EXACT [] synonym: "rho-associated, coiled-coil-containing protein kinase 1" EXACT [] xref: IUPHARobj:1503 is_a: PR:000000024 ! Rho-associated protein kinase [Term] id: PR:000026574 name: Rho-associated protein kinase 1 isoform 1, initiator methionine removed form def: "A Rho-associated protein kinase 1 isoform 1 that has had the initiator methionine removed." [PRO:DNx] comment: Category=modification. synonym: "ROCK1/iso:1/InitMet-" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000000307 ! Rho-associated protein kinase 1 isoform 1 intersection_of: lacks_part PR:000021937 ! initiator methionine [Term] id: PR:Q13464 name: Rho-associated protein kinase 1 (human) def: "A Rho-associated protein kinase 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13464] comment: Category=organism-gene. synonym: "ROCK1" RELATED Gene-based [UniProtKB:Q13464] synonym: "hROCK1" EXACT PRO-short-label [PRO:DNx] synonym: "ROCK-I (human)" EXACT [UniProtKB:Q13464] synonym: "p160ROCK (human)" EXACT [UniProtKB:Q13464] synonym: "p160 ROCK-1 (human)" EXACT [UniProtKB:Q13464] synonym: "renal carcinoma antigen NY-REN-35 (human)" EXACT [UniProtKB:Q13464] synonym: "Rho-associated, coiled-coil-containing protein kinase 1 (human)" EXACT [UniProtKB:Q13464] synonym: "Rho-associated, coiled-coil-containing protein kinase I (human)" EXACT [UniProtKB:Q13464] xref: DTO:03100456 xref: UniProtKB:Q13464 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000120 ! Rho-associated protein kinase 1 relationship: has_gene_template HGNC:10251 ! ROCK1 (human) [Term] id: PR:P70335-1 name: Rho-associated protein kinase 1 isoform 1 (mouse) def: "A Rho-associated protein kinase 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA] comment: Category=organism-sequence. synonym: "mROCK1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P70335-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000307 ! Rho-associated protein kinase 1 isoform 1 [Term] id: PR:P70335-2 name: Rho-associated protein kinase 1 isoform m2 (mouse) def: "A Rho-associated protein kinase 1 (mouse) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P70335-2." [PRO:DNx, UniProtKB:P70335] comment: Category=organism-sequence. synonym: "mROCK1/iso:m2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P70335-2 is_a: PR:P70335 ! Rho-associated protein kinase 1 (mouse) relationship: only_in_taxon NCBITaxon:10090 ! Mus musculus [Term] id: PR:000044586 name: Rho-associated protein kinase 1 isoform 1 unmodified form (human) def: "A Rho-associated protein kinase 1 isoform 1 unmodified form in human." [PRO:DNx] comment: Category=organism-modification. synonym: "hROCK1/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000002529 ! Rho-associated protein kinase 1 isoform 1 unmodified form [Term] id: PR:000000307 name: Rho-associated protein kinase 1 isoform 1 def: "A Rho-associated protein kinase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13464-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] comment: Category=sequence. Note: In resting cells, the C-terminal Rho-binding and PH domain mask the protein kinase catalytic domain, activation occurs through a conformational change. synonym: "ROCK1/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "ROCK1 sequence 1" EXACT [] is_a: PR:000000120 ! Rho-associated protein kinase 1 [Term] id: PR:P70335 name: Rho-associated protein kinase 1 (mouse) def: "A Rho-associated protein kinase 1 that is encoded in the genome of mouse." [OMA:P70335, PRO:DNx] comment: Category=organism-gene. synonym: "Rock1" RELATED Gene-based [UniProtKB:P70335] synonym: "mROCK1" EXACT PRO-short-label [PRO:DNx] synonym: "ROCK-I (mouse)" EXACT [UniProtKB:P70335] synonym: "p160ROCK (mouse)" EXACT [UniProtKB:P70335] synonym: "p160 ROCK-1 (mouse)" EXACT [UniProtKB:P70335] synonym: "Rho-associated, coiled-coil-containing protein kinase 1 (mouse)" EXACT [UniProtKB:P70335] synonym: "Rho-associated, coiled-coil-containing protein kinase I (mouse)" EXACT [UniProtKB:P70335] xref: UniProtKB:P70335 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000120 ! Rho-associated protein kinase 1 relationship: has_gene_template MGI:107927 ! Rock1 (mouse) [Term] id: PR:Q63644 name: Rho-associated protein kinase 1 (rat) def: "A Rho-associated protein kinase 1 that is encoded in the genome of rat." [OMA:Q63644, PANTHER:PTHR22988:SF3, PRO:DNx] comment: Category=organism-gene. synonym: "Rock1" RELATED Gene-based [UniProtKB:Q63644] synonym: "rROCK1" EXACT PRO-short-label [PRO:DNx] synonym: "Ac2-154" RELATED Gene-based [UniProtKB:Q63644] synonym: "ROCK-I (rat)" EXACT [UniProtKB:Q63644] synonym: "p160ROCK (rat)" EXACT [UniProtKB:Q63644] synonym: "p160 ROCK-1 (rat)" EXACT [UniProtKB:Q63644] synonym: "p150 RhoA-binding kinase ROK beta (rat)" EXACT [UniProtKB:Q63644] synonym: "liver regeneration-related protein LRRG199 (rat)" EXACT [UniProtKB:Q63644] synonym: "Rho-associated, coiled-coil-containing protein kinase 1 (rat)" EXACT [UniProtKB:Q63644] synonym: "Rho-associated, coiled-coil-containing protein kinase I (rat)" EXACT [UniProtKB:Q63644] xref: UniProtKB:Q63644 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000000120 ! Rho-associated protein kinase 1 relationship: has_gene_template RGD:620424 ! Rock1 (rat) [Term] id: PR:Q63644-2 name: Rho-associated protein kinase 1 isoform r2 (rat) def: "A Rho-associated protein kinase 1 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q63644-2." [PRO:DNx, UniProtKB:Q63644] comment: Category=organism-sequence. synonym: "rROCK1/iso:r2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q63644-2 is_a: PR:Q63644 ! Rho-associated protein kinase 1 (rat) relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus [Term] id: PR:000036476 name: Rho-associated protein kinase 1 isoform 1 cleaved 1 (mouse) def: "A Rho-associated protein kinase 1 isoform 1 cleaved 1 in mouse. UniProtKB:P70335-1, 1-1113." [PMID:11283607, PMID:16983089, PRO:CNA] comment: Category=organism-modification. synonym: "mROCK1/iso:1/Clv:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P70335-1, 1-1113" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000563 ! Rho-associated protein kinase 1 isoform 1 cleaved 1 [Term] id: PR:Q13464-1 name: Rho-associated protein kinase 1 isoform 1 (human) def: "A Rho-associated protein kinase 1 isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hROCK1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q13464-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000307 ! Rho-associated protein kinase 1 isoform 1 [Term] id: PR:Q63644-1 name: Rho-associated protein kinase 1 isoform r1 (rat) def: "A Rho-associated protein kinase 1 (rat) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q63644-1." [PRO:DNx, UniProtKB:Q63644] comment: Category=organism-sequence. synonym: "rROCK1/iso:r1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q63644-1 is_a: PR:Q63644 ! Rho-associated protein kinase 1 (rat) relationship: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus