[Term] id: PR:P97471 name: mothers against decapentaplegic homolog 4 (mouse) def: "A smad4 that is encoded in the genome of mouse." [OMA:P97471, PRO:DNx] comment: Category=organism-gene. synonym: "Dpc4" RELATED Gene-based [UniProtKB:P97471] synonym: "Madh4" RELATED Gene-based [UniProtKB:P97471] synonym: "Smad4" RELATED Gene-based [UniProtKB:P97471] synonym: "mSMAD4" EXACT PRO-short-label [PRO:DNx] synonym: "SMAD 4 (mouse)" EXACT [UniProtKB:P97471] synonym: "MAD homolog 4 (mouse)" EXACT [UniProtKB:P97471] synonym: "SMAD family member 4 (mouse)" EXACT [UniProtKB:P97471] synonym: "mothers against DPP homolog 4 (mouse)" EXACT [UniProtKB:P97471] synonym: "deletion target in pancreatic carcinoma 4 homolog (mouse)" EXACT [UniProtKB:P97471] xref: UniProtKB:P97471 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000128 ! smad4 relationship: has_gene_template MGI:894293 ! Smad4 (mouse) [Term] id: PR:000000579 name: smad4 isoform 1 phosphorylated 1 def: "A smad4 isoform 1 phosphorylated form in which the phosphorylation occurs within the PxTP motif located in the MH1-MH2 domain linker region. Example: UniProtKB:Q13485-1, Thr-277, MOD:00047." [PMID:12801888] comment: Category=modification. synonym: "SMAD4/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000476 ! smad4 isoform 1 phosphorylated form relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000045915 name: mothers against decapentaplegic homolog 4 phosphorylated 1 (human) def: "A mothers against decapentaplegic homolog 4 (human) that has been phosphorylated at Thr-77. UniProtKB:Q13485, Thr-77, MOD:00047." [PMID:20974850, iPTMnet:Q13485] comment: Category=organism-modification. Evidence=(ECO:0000006, based on PMID:20974850). Status=unreviewed. synonym: "hSMAD4/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q13485, Thr-77, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] is_a: PR:Q13485 ! mothers against decapentaplegic homolog 4 (human) relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:O70437 name: mothers against decapentaplegic homolog 4 (rat) def: "A smad4 that is encoded in the genome of rat." [OMA:O70437, PANTHER:PTHR13703:SF13, PRO:DNx] comment: Category=organism-gene. synonym: "Madh4" RELATED Gene-based [UniProtKB:O70437] synonym: "Smad4" RELATED Gene-based [UniProtKB:O70437] synonym: "rSMAD4" EXACT PRO-short-label [PRO:DNx] synonym: "SMAD 4 (rat)" EXACT [UniProtKB:O70437] synonym: "MAD homolog 4 (rat)" EXACT [UniProtKB:O70437] synonym: "SMAD family member 4 (rat)" EXACT [UniProtKB:O70437] synonym: "mothers against DPP homolog 4 (rat)" EXACT [UniProtKB:O70437] xref: UniProtKB:O70437 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000000128 ! smad4 relationship: has_gene_template RGD:3033 ! Smad4 (rat) [Term] id: PR:000000128 name: smad4 def: "A smad protein that is a translation product of the human SMAD4 gene or a 1:1 ortholog thereof. It lacks the C-terminal SSxS motif, necessary for receptor mediated phosphorylation, that is present in the receptor-regulated smads." [PMID:10708949, PRO:CNA] comment: Category=gene. synonym: "DPC4" RELATED Gene-based [] synonym: "MADH4" RELATED Gene-based [] synonym: "SMAD4" EXACT PRO-short-label [PRO:DNx] synonym: "SMAD 4" EXACT [] synonym: "MAD homolog 4" EXACT [] synonym: "SMAD family member 4" EXACT [] synonym: "mothers against DPP homolog 4" EXACT [] synonym: "deletion target in pancreatic carcinoma 4" EXACT [] synonym: "deletion target in pancreatic carcinoma 4 homolog" EXACT [] xref: PIRSF:PIRSF500408 is_a: PR:000000027 ! smad protein [Term] id: PR:000000370 name: smad4 sequence variant G386D (human) def: "A mothers against decapentaplegic homolog 4 (human) that has an Asp residue at the position equivalent to Gly-386 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Gly-386, CHEBI:29958." [PMID:15031030, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hSMAD4/var:G386D" EXACT PRO-short-label [PRO:DNx] synonym: "smad4 sequence variant 4 (human)" EXACT [PRO:DNx] synonym: "UniProtKB:Q13485, Gly-386, CHEBI:29958" EXACT PRO-proteoform-std [PRO:DAN] xref: UniProtKB_VAR:VAR_019573 is_a: PR:Q13485 ! mothers against decapentaplegic homolog 4 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000371 name: smad4 sequence variant D493H (human) def: "A mothers against decapentaplegic homolog 4 (human) that has a His residue at the position equivalent to Asp-493 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Asp-493, CHEBI:29979." [PMID:8553070, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hSMAD4/var:D493H" EXACT PRO-short-label [PRO:DNx] synonym: "smad4 sequence variant 5 (human)" EXACT [PRO:DNx] synonym: "UniProtKB:Q13485, Asp-493, CHEBI:29979" EXACT PRO-proteoform-std [PRO:DAN] xref: UniProtKB_VAR:VAR_011380 is_a: PR:Q13485 ! mothers against decapentaplegic homolog 4 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q13485-1 name: mothers against decapentaplegic homolog 4 isoform 1 (human) def: "A smad4 isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hSMAD4/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q13485-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000366 ! smad4 isoform 1 [Term] id: PR:000049288 name: mothers against decapentaplegic homolog 4 ADP-ribosylated form (human) def: "A mothers against decapentaplegic homolog 4 (human) that includes at least one ADP-ribosylated residue. UniProtKB:Q13485, MOD:00752." [PRO:DNx, Reactome:R-HSA-2187323] comment: Category=organism-modification. synonym: "hSMAD4/ADPribRes+" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q13485, MOD:00752" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-2187323 "PR:000049288 located_in GO:0005654" intersection_of: has_part MOD:00752 ! monoadenosine diphosphoribosyl (ADP-ribosyl) modified residue intersection_of: PR:Q13485 ! mothers against decapentaplegic homolog 4 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000002539 name: smad4 isoform 1 unmodified form def: "A smad4 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx] comment: Category=modification. synonym: "SMAD4/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000000366 ! smad4 isoform 1 intersection_of: has_part PR:000021935 ! immature protein part intersection_of: lacks_part PR:000025513 ! modified amino-acid residue disjoint_from: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000036483 name: mothers against decapentaplegic homolog 4 isoform 1 phosphorylated 1 (human) def: "A smad4 isoform 1 phosphorylated 1 in human. UniProtKB:Q13485-1, Thr-277, MOD:00047." [PMID:12801888, PRO:CNA] comment: Category=organism-modification. synonym: "hSMAD4/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q13485-1, Thr-277, MOD:00047" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000579 ! smad4 isoform 1 phosphorylated 1 relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:Q13485 name: mothers against decapentaplegic homolog 4 (human) def: "A smad4 that is encoded in the genome of human." [PRO:CNA, UniProtKB:Q13485] comment: Category=organism-gene. synonym: "DPC4" RELATED Gene-based [UniProtKB:Q13485] synonym: "MADH4" RELATED Gene-based [UniProtKB:Q13485] synonym: "SMAD4" RELATED Gene-based [UniProtKB:Q13485] synonym: "hSMAD4" EXACT PRO-short-label [PRO:DNx] synonym: "Smad4 (human)" EXACT [UniProtKB:Q13485] synonym: "SMAD 4 (human)" EXACT [UniProtKB:Q13485] synonym: "MAD homolog 4 (human)" EXACT [UniProtKB:Q13485] synonym: "SMAD family member 4 (human)" EXACT [UniProtKB:Q13485] synonym: "mothers against DPP homolog 4 (human)" EXACT [UniProtKB:Q13485] synonym: "deletion target in pancreatic carcinoma 4 (human)" EXACT [UniProtKB:Q13485] xref: Reactome:R-HSA-170862 "PR:Q13485 located_in GO:0005829" xref: Reactome:R-HSA-177103 "PR:Q13485 located_in GO:0005654" xref: UniProtKB:Q13485 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000128 ! smad4 relationship: has_gene_template HGNC:6770 ! SMAD4 (human) [Term] id: PR:P97471-1 name: mothers against decapentaplegic homolog 4 isoform 1 (mouse) def: "A smad4 isoform 1 that is encoded in the genome of mouse." [PRO:CNA] comment: Category=organism-sequence. synonym: "mSMAD4/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P97471-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000366 ! smad4 isoform 1 [Term] id: PR:000025958 name: mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 2 (human) def: "A smad4 isoform 1 monoubiquitinated 2 in human. UniProtKB:Q13485-1, Lys-519, MOD:01148." [PMID:19135894] comment: Category=organism-modification. synonym: "hSMAD4/iso:1/MonoUbiq:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q13485-1, Lys-519, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000025957 ! smad4 isoform 1 monoubiquitinated 2 relationship: has_part MOD:01148 ! ubiquitinylated lysine [Term] id: PR:000025957 name: smad4 isoform 1 monoubiquitinated 2 def: "A smad4 isoform 1 that has been monoubiquitinated on a lysine residue within the MH2 domain by E3 ubiquitin-protein ligase TRIM33. Example: UniProtKB:Q13485-1, Lys-519, MOD:01148." [PMID:18783722] comment: Category=modification. synonym: "SMAD4/iso:1/MonoUbiq:2" EXACT PRO-short-label [PRO:DNx] synonym: "mono-ubiquitinated smad4" RELATED [] is_a: PR:000000366 ! smad4 isoform 1 relationship: has_part MOD:01148 ! ubiquitinylated lysine [Term] id: PR:000025956 name: mothers against decapentaplegic homolog 4 isoform 1 monoubiquitinated 1 (human) def: "A smad4 isoform 1 monoubiquitinated 1 in human. UniProtKB:Q13485-1, Lys-507, MOD:01148." [PMID:18783722] comment: Category=organism-modification. synonym: "hSMAD4/iso:1/MonoUbiq:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q13485-1, Lys-507, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000025955 ! smad4 isoform 1 monoubiquitinated 1 relationship: has_part MOD:01148 ! ubiquitinylated lysine [Term] id: PR:000025955 name: smad4 isoform 1 monoubiquitinated 1 def: "A smad4 isoform 1 that has been monoubiquitinated on a lysine residue within the MH2 domain. Example: UniProtKB:Q13485-1, Lys-507, MOD:01148." [PMID:18783722] comment: Category=modification. synonym: "SMAD4/iso:1/MonoUbiq:1" EXACT PRO-short-label [PRO:DNx] synonym: "mono-ubiquitinated smad4" RELATED [] is_a: PR:000000366 ! smad4 isoform 1 relationship: has_part MOD:01148 ! ubiquitinylated lysine [Term] id: PR:000000367 name: smad4 sequence variant E330G (human) def: "A mothers against decapentaplegic homolog 4 (human) that has a Gly residue at the position equivalent to Glu-330 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Glu-330, CHEBI:29947." [PMID:12417513, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hSMAD4/var:E330G" EXACT PRO-short-label [PRO:DNx] synonym: "smad4 sequence variant 1 (human)" EXACT [PRO:DNx] synonym: "UniProtKB:Q13485, Glu-330, CHEBI:29947" EXACT PRO-proteoform-std [PRO:DAN] xref: UniProtKB_VAR:VAR_022833 is_a: PR:Q13485 ! mothers against decapentaplegic homolog 4 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000366 name: smad4 isoform 1 def: "A smad4 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13485-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] comment: Category=sequence. synonym: "SMAD4/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000128 ! smad4 [Term] id: PR:000000369 name: smad4 sequence variant R361C (human) def: "A mothers against decapentaplegic homolog 4 (human) that has a Cys residue at the position equivalent to Arg-361 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Arg-361, CHEBI:29950." [PMID:9811934, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hSMAD4/var:R361C" EXACT PRO-short-label [PRO:DNx] synonym: "smad4 sequence variant 3 (human)" EXACT [PRO:DNx] synonym: "UniProtKB:Q13485, Arg-361, CHEBI:29950" EXACT PRO-proteoform-std [PRO:DAN] xref: Reactome:R-HSA-3310983 "PR:000000369 located_in GO:0005829" xref: UniProtKB_VAR:VAR_019572 is_a: PR:Q13485 ! mothers against decapentaplegic homolog 4 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000368 name: smad4 sequence variant G352R (human) def: "A mothers against decapentaplegic homolog 4 (human) that has an Arg residue at the position equivalent to Gly-352 of the amino acid sequence represented by UniProtKB:Q13485. UniProtKB:Q13485, Gly-352, CHEBI:29952." [PMID:12417513, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hSMAD4/var:G352R" EXACT PRO-short-label [PRO:DNx] synonym: "smad4 sequence variant 2 (human)" EXACT [PRO:DNx] synonym: "UniProtKB:Q13485, Gly-352, CHEBI:29952" EXACT PRO-proteoform-std [PRO:DAN] xref: UniProtKB_VAR:VAR_019571 is_a: PR:Q13485 ! mothers against decapentaplegic homolog 4 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000476 name: smad4 isoform 1 phosphorylated form def: "A smad4 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA] comment: Category=modification. synonym: "SMAD4/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx] intersection_of: has_part MOD:00696 ! phosphorylated residue intersection_of: PR:000000366 ! smad4 isoform 1