[Term] id: PR:000049430 name: transforming growth factor beta-1, signal peptide removed form (human) def: "A transforming growth factor beta-1 (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390." [PRO:DNx, Reactome:R-HSA-114705] comment: Category=organism-modification. synonym: "hTGFB1/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P01137, 30-390" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-114705 "PR:000049430 located_in GO:0005796" intersection_of: PR:P01137 ! transforming growth factor beta-1 (human) intersection_of: lacks_part SO:0000418 ! signal_peptide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P01137-1 name: transforming growth factor beta-1 isoform 1 (human) def: "A TGF-beta 1 isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. synonym: "hTGFB1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P01137-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000397 ! TGF-beta 1 isoform 1 [Term] id: PR:P04202 name: transforming growth factor beta-1 proprotein (mouse) def: "A TGF-beta 1 that is encoded in the genome of mouse." [OMA:P04202, PRO:DNx] comment: Category=organism-gene. synonym: "Tgfb1" RELATED Gene-based [UniProtKB:P04202] synonym: "mTGFB1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P04202 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000182 ! TGF-beta 1 relationship: has_gene_template MGI:98725 ! Tgfb1 (mouse) [Term] id: PR:000000398 name: TGF-beta 1 sequence variant L10P (human) def: "A transforming growth factor beta-1 (human) that has a Pro residue at the position equivalent to Leu-10 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Leu-10, CHEBI:50342." [PMID:12202987, PMID:3861940, PMID:9783545, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hTGFB1/var:L10P" EXACT PRO-short-label [PRO:DNx] synonym: "TGF-beta 1 sequence variant 1 (human)" EXACT [PRO:DNx] synonym: "UniProtKB:P01137, Leu-10, CHEBI:50342" EXACT PRO-proteoform-std [PRO:DAN] xref: UniProtKB_VAR:VAR_016171 is_a: PR:P01137 ! transforming growth factor beta-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000399 name: TGF-beta 1 sequence variant T81H (human) def: "A transforming growth factor beta-1 (human) that has a His residue at the position equivalent to Tyr-81 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Tyr-81, CHEBI:29979." [PMID:11062463, PMID:12493741, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hTGFB1/var:T81H" EXACT PRO-short-label [PRO:DNx] synonym: "TGF-beta 1 sequence variant 2 (human)" EXACT [PRO:DNx] synonym: "UniProtKB:P01137, Tyr-81, CHEBI:29979" EXACT PRO-proteoform-std [PRO:DAN] xref: UniProtKB_VAR:VAR_017607 is_a: PR:P01137 ! transforming growth factor beta-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000025930 name: TGF-beta 1 isoform 1 mature form (green monkey) def: "A TGF-beta 1 isoform 1 mature form in green monkey. UniProtKB:P09533-1, 279-390." [PMID:3185545] comment: Category=organism-modification. synonym: "PRO_0000033761" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "GrMonkey-TGFB1/iso:1/mature" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P09533-1, 279-390" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9534 ! Chlorocebus aethiops intersection_of: PR:000000616 ! TGF-beta 1 isoform 1 mature form [Term] id: PR:000026335 name: TGF-beta 1 isoform 1 inactive form (human) def: "A TGF-beta 1 isoform 1 inactive form in human, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PRO:DAN] comment: Category=organism-modification. synonym: "hTGFB1/iso:1/inactive" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000033762, PRO_0000033763, Asn-82, MOD:00160" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000618 ! TGF-beta 1 isoform 1 inactive form relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine [Term] id: PR:000025928 name: TGF-beta 1 isoform 1 mature form (mouse) def: "A TGF-beta 1 isoform 1 mature form in mouse. UniProtKB:P04202-1, 279-390." [PMID:2209468] comment: Category=organism-modification. synonym: "PRO_0000033767" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "mTGFB1/iso:1/mature" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P04202-1, 279-390" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000616 ! TGF-beta 1 isoform 1 mature form [Term] id: PR:000025929 name: TGF-beta 1 isoform 1 mature form (rat) def: "A TGF-beta 1 isoform 1 mature form in rat. UniProtKB:P17246-1, 279-390." [PMID:11453552] comment: Category=organism-modification. synonym: "PRO_0000033771" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "rTGFB1/iso:1/mature" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P17246-1, 279-390" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000000616 ! TGF-beta 1 isoform 1 mature form [Term] id: PR:000025927 name: TGF-beta 1 isoform 1 mature form (human) def: "A TGF-beta 1 isoform 1 mature form in human. UniProtKB:P01137-1, 279-390." [PMID:3162913] comment: Category=organism-modification. synonym: "PRO_0000033763" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "hTGFB1/iso:1/mature" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P01137-1, 279-390" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-170838 "PR:000025927 located_in GO:0005576" xref: Reactome:R-HSA-177108 "PR:000025927 located_in GO:0005796" xref: Reactome:R-HSA-5146781 "PR:000025927 located_in GO:0005886" intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000616 ! TGF-beta 1 isoform 1 mature form [Term] id: PR:000000397 name: TGF-beta 1 isoform 1 def: "A TGF-beta 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P01137-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] comment: Category=sequence. synonym: "TGFB1/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000182 ! TGF-beta 1 [Term] id: PR:P09533-1 name: transforming growth factor beta-1 isoform 1 (green monkey) def: "A TGF-beta 1 isoform 1 that is encoded in the genome of green monkey." [PRO:DAN] comment: Category=organism-sequence. synonym: "GrMonkey-TGFB1/iso:1" EXACT PRO-short-label [PRO:DAN] xref: UniProtKB:P09533-1 intersection_of: only_in_taxon NCBITaxon:9534 ! Chlorocebus aethiops intersection_of: PR:000000397 ! TGF-beta 1 isoform 1 [Term] id: PR:000018291 name: TGF-beta 1, signal peptide removed form def: "A TGF-beta 1 that has had the signal peptide removed." [PRO:DNx] comment: Category=modification. synonym: "TGFB1/SigPep-" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000000182 ! TGF-beta 1 intersection_of: lacks_part SO:0000418 ! signal_peptide [Term] id: PR:000018292 name: TGF-beta 1 proteolytic cleavage product def: "A TGF-beta 1 that has been processed by proteolytic cleavage." [PRO:DNx] comment: Category=modification. synonym: "TGFB1/ClvPrd" EXACT PRO-short-label [PRO:DNx] intersection_of: output_of GO:0016485 ! protein processing intersection_of: PR:000000182 ! TGF-beta 1 [Term] id: PR:000000182 name: TGF-beta 1 def: "A TGF-beta that is a translation product of the human TGFB1 gene or a 1:1 ortholog thereof." [PRO:CNA] comment: Category=gene. synonym: "TGFB" RELATED Gene-based [] synonym: "TGFB1" EXACT PRO-short-label [PRO:DNx] synonym: "TGF-beta-1" EXACT [] is_a: PR:000000046 ! TGF-beta [Term] id: PR:000000620 name: TGF-beta 1 sequence variant T81H cleaved 2 (human) def: "A TGF-beta 1 sequence variant T81H, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979." [PMID:12493741, PRO:CNA, PRO:DAN] comment: Category=organism-modification. synonym: "hTGFB1/var:T81H/Clv:2" EXACT PRO-short-label [PRO:DAN] synonym: "UniProtKB:P01137, 30-278, Tyr-81, CHEBI:29979" EXACT PRO-proteoform-std [PRO:DAN] synonym: "TGF-beta 1 sequence variant 2 cleaved 2 (human)" EXACT [PRO:DAN] is_a: PR:000021903 ! TGF-beta 1 sequence variant T81H, signal peptide removed form (human) relationship: output_of GO:0016485 ! protein processing relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000621 name: TGF-beta 1 sequence variant R218C cleaved 1 (human) def: "A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950." [PMID:11278244, PRO:CNA, PRO:DAN] comment: Category=organism-modification. synonym: "hTGFB1/var:R218C/Clv:1" EXACT PRO-short-label [PRO:DAN] synonym: "TGF-beta 1 sequence variant 3 cleaved 1 (human)" EXACT [PRO:DAN] synonym: "UniProtKB:P01137, 279-390, Arg-218, CHEBI:29950" EXACT PRO-proteoform-std [PRO:DAN] is_a: PR:000021904 ! TGF-beta 1 sequence variant R218C, signal peptide removed form (human) relationship: output_of GO:0016485 ! protein processing relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000622 name: TGF-beta 1 sequence variant R218C cleaved 2 (human) def: "A TGF-beta 1 sequence variant R218C, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide (PR:000000621). UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950." [PMID:10973241, PMID:11062463, PMID:11278244, PMID:12493741, PMID:12843182, PRO:CNA, PRO:DAN] comment: Category=organism-modification. synonym: "hTGFB1/var:R218C/Clv:2" EXACT PRO-short-label [PRO:DAN] synonym: "UniProtKB:P01137, 30-278, Arg-218, CHEBI:29950" EXACT PRO-proteoform-std [PRO:DAN] synonym: "TGF-beta 1 sequence variant 3 cleaved 2 (human)" EXACT [PRO:DAN] is_a: PR:000021904 ! TGF-beta 1 sequence variant R218C, signal peptide removed form (human) relationship: output_of GO:0016485 ! protein processing relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000623 name: TGF-beta 1 sequence variant H222D cleaved 1 (human) def: "A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, His-222, CHEBI:29958." [PRO:CNA, PRO:DAN] comment: Category=organism-modification. synonym: "hTGFB1/var:H222D/Clv:1" EXACT PRO-short-label [PRO:DAN] synonym: "TGF-beta 1 sequence variant 5 cleaved 1 (human)" EXACT [PRO:DAN] synonym: "UniProtKB:P01137, 279-390, His-222, CHEBI:29958" EXACT PRO-proteoform-std [PRO:DAN] is_a: PR:000021905 ! TGF-beta 1 sequence variant H222D, signal peptide removed form (human) relationship: output_of GO:0016485 ! protein processing relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000624 name: TGF-beta 1 sequence variant H222D cleaved 2 (human) def: "A TGF-beta 1 sequence variant H222D, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, His-222, CHEBI:29958." [PMID:11278244, PRO:CNA, PRO:DAN] comment: Category=organism-modification. synonym: "hTGFB1/var:H222D/Clv:2" EXACT PRO-short-label [PRO:DAN] synonym: "UniProtKB:P01137, 30-278, His-222, CHEBI:29958" EXACT PRO-proteoform-std [PRO:DAN] synonym: "TGF-beta 1 sequence variant 5 cleaved 2 (human)" EXACT [PRO:DAN] is_a: PR:000021905 ! TGF-beta 1 sequence variant H222D, signal peptide removed form (human) relationship: output_of GO:0016485 ! protein processing relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000625 name: TGF-beta 1 sequence variant C225R cleaved 1 (human) def: "A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952." [PRO:CNA, PRO:DAN] comment: Category=organism-modification. synonym: "hTGFB1/var:C225R/Clv:1" EXACT PRO-short-label [PRO:DAN] synonym: "TGF-beta 1 sequence variant 6 cleaved 1 (human)" EXACT [PRO:DAN] synonym: "UniProtKB:P01137, 279-390, Cys-225, CHEBI:29952" EXACT PRO-proteoform-std [PRO:DAN] is_a: PR:000021906 ! TGF-beta 1 sequence variant C225R, signal peptide removed form (human) relationship: output_of GO:0016485 ! protein processing relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000626 name: TGF-beta 1 sequence variant C225R cleaved 2 (human) def: "A TGF-beta 1 sequence variant C225R, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952." [PMID:11278244, PRO:CNA, PRO:DAN] comment: Category=organism-modification. synonym: "hTGFB1/var:C225R/Clv:2" EXACT PRO-short-label [PRO:DAN] synonym: "UniProtKB:P01137, 30-278, Cys-225, CHEBI:29952" EXACT PRO-proteoform-std [PRO:DAN] synonym: "TGF-beta 1 sequence variant 6 cleaved 2 (human)" EXACT [PRO:DAN] is_a: PR:000021906 ! TGF-beta 1 sequence variant C225R, signal peptide removed form (human) relationship: output_of GO:0016485 ! protein processing relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000627 name: TGF-beta 1 sequence variant R218H cleaved 1 (human) def: "A TGF-beta 1 sequence variant R218H, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979." [PMID:11278244, PRO:CNA, PRO:DAN] comment: Category=organism-modification. synonym: "hTGFB1/var:R218H/Clv:1" EXACT PRO-short-label [PRO:DAN] synonym: "TGF-beta 1 sequence variant 4 cleaved 1 (human)" EXACT [PRO:DAN] synonym: "UniProtKB:P01137, 279-390, Arg-218, CHEBI:29979" EXACT PRO-proteoform-std [PRO:DAN] is_a: PR:000021907 ! TGF-beta 1 sequence variant R218H, signal peptide removed form (human) relationship: output_of GO:0016485 ! protein processing relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000628 name: TGF-beta 1 sequence variant R218H cleaved 2 (human) def: "A TGF-beta 1 sequence variant R218H, signal peptide removed form (human) that has been processed by subsequent removal of the C-terminal mature peptide. This chain is referred as to the latency associated peptide (LAP). This form has decreased affinity for the mature peptide. UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979." [PMID:11278244, PRO:CNA, PRO:DAN] comment: Category=organism-modification. synonym: "hTGFB1/var:R218H/Clv:2" EXACT PRO-short-label [PRO:DAN] synonym: "UniProtKB:P01137, 30-278, Arg-218, CHEBI:29979" EXACT PRO-proteoform-std [PRO:DAN] synonym: "TGF-beta 1 sequence variant 4 cleaved 2 (human)" EXACT [PRO:DAN] is_a: PR:000021907 ! TGF-beta 1 sequence variant R218H, signal peptide removed form (human) relationship: output_of GO:0016485 ! protein processing relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000400 name: TGF-beta 1 sequence variant R218C (human) def: "A transforming growth factor beta-1 (human) that has a Cys residue at the position equivalent to Arg-218 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Arg-218, CHEBI:29950." [PMID:10973241, PMID:11062463, PMID:12493741, PMID:12843182, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hTGFB1/var:R218C" EXACT PRO-short-label [PRO:DNx] synonym: "TGF-beta 1 sequence variant 3 (human)" EXACT [PRO:DNx] synonym: "UniProtKB:P01137, Arg-218, CHEBI:29950" EXACT PRO-proteoform-std [PRO:DAN] xref: UniProtKB_VAR:VAR_017608 is_a: PR:P01137 ! transforming growth factor beta-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000401 name: TGF-beta 1 sequence variant R218H (human) def: "A transforming growth factor beta-1 (human) that has a His residue at the position equivalent to Arg-218 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Arg-218, CHEBI:29979." [PMID:11062463, PMID:12493741, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hTGFB1/var:R218H" EXACT PRO-short-label [PRO:DNx] synonym: "TGF-beta 1 sequence variant 4 (human)" EXACT [PRO:DNx] synonym: "UniProtKB:P01137, Arg-218, CHEBI:29979" EXACT PRO-proteoform-std [PRO:DAN] xref: UniProtKB_VAR:VAR_017609 is_a: PR:P01137 ! transforming growth factor beta-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000402 name: TGF-beta 1 sequence variant H222D (human) def: "A transforming growth factor beta-1 (human) that has an Asp residue at the position equivalent to His-222 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, His-222, CHEBI:29958." [PMID:12493741, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hTGFB1/var:H222D" EXACT PRO-short-label [PRO:DNx] synonym: "TGF-beta 1 sequence variant 5 (human)" EXACT [PRO:DNx] synonym: "UniProtKB:P01137, His-222, CHEBI:29958" EXACT PRO-proteoform-std [PRO:DAN] xref: UniProtKB_VAR:VAR_017610 is_a: PR:P01137 ! transforming growth factor beta-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000403 name: TGF-beta 1 sequence variant C225R (human) def: "A transforming growth factor beta-1 (human) that has an Arg residue at the position equivalent to Cys-225 of the amino acid sequence represented by UniProtKB:P01137. UniProtKB:P01137, Cys-225, CHEBI:29952." [PMID:12493741, PRO:CNA, PRO:DAN] comment: Category=organism-sequence. synonym: "hTGFB1/var:C225R" EXACT PRO-short-label [PRO:DNx] synonym: "TGF-beta 1 sequence variant 6 (human)" EXACT [PRO:DNx] synonym: "UniProtKB:P01137, Cys-225, CHEBI:29952" EXACT PRO-proteoform-std [PRO:DAN] xref: UniProtKB_VAR:VAR_017611 is_a: PR:P01137 ! transforming growth factor beta-1 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:Q9VQG9 name: dawdle, isoform A (fruit fly) def: "A TGF-beta 1 that is encoded in the genome of fruit fly." [OMA:Q9VQG9, PRO:CNA] comment: Category=organism-gene. synonym: "Alp23B" RELATED Gene-based [UniProtKB:Q9VQG9] synonym: "CG16987" RELATED Gene-based [UniProtKB:Q9VQG9] synonym: "fly-TGFB1" EXACT PRO-short-label [PRO:DNx] synonym: "GH14433p (fruit fly)" EXACT [UniProtKB:Q9VQG9] synonym: "dawdle, isoform B (fruit fly)" EXACT [UniProtKB:Q9VQG9] synonym: "dawdle, isoform C (fruit fly)" EXACT [UniProtKB:Q9VQG9] xref: UniProtKB:Q9VQG9 intersection_of: only_in_taxon NCBITaxon:7227 ! Drosophila melanogaster intersection_of: PR:000000182 ! TGF-beta 1 relationship: has_gene_template FlyBase:FBgn0031461 ! daw (fruit fly) [Term] id: PR:000002555 name: TGF-beta 1 isoform 1 unmodified form def: "A TGF-beta 1 isoform 1 that has not been subjected to any co- or post-translational residue modification or peptide bond cleavage." [PRO:DNx] comment: Category=modification. synonym: "TGFB1/iso:1/UnMod" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000000397 ! TGF-beta 1 isoform 1 intersection_of: has_part PR:000021935 ! immature protein part intersection_of: lacks_part PR:000025513 ! modified amino-acid residue disjoint_from: PR:000018264 ! proteolytic cleavage product [Term] id: PR:000021904 name: TGF-beta 1 sequence variant R218C, signal peptide removed form (human) def: "A TGF-beta 1 sequence variant R218C (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Arg-218, CHEBI:29950." [PRO:DAN] comment: Category=organism-modification. synonym: "hTGFB1/var:R218C/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P01137, 30-390, Arg-218, CHEBI:29950" EXACT PRO-proteoform-std [PRO:DAN] synonym: "TGF-beta 1 sequence variant 3, signal peptide removed form (human)" EXACT [PRO:DNx] intersection_of: PR:000000400 ! TGF-beta 1 sequence variant R218C (human) intersection_of: lacks_part SO:0000418 ! signal_peptide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000021905 name: TGF-beta 1 sequence variant H222D, signal peptide removed form (human) def: "A TGF-beta 1 sequence variant H222D (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, His-222, CHEBI:29958." [PRO:DNx] comment: Category=organism-modification. synonym: "hTGFB1/var:H222D/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P01137, 30-390, His-222, CHEBI:29958" EXACT PRO-proteoform-std [PRO:DAN] synonym: "TGF-beta 1 sequence variant 5, signal peptide removed form (human)" EXACT [PRO:DNx] intersection_of: PR:000000402 ! TGF-beta 1 sequence variant H222D (human) intersection_of: lacks_part SO:0000418 ! signal_peptide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000021906 name: TGF-beta 1 sequence variant C225R, signal peptide removed form (human) def: "A TGF-beta 1 sequence variant C225R (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Cys-225, CHEBI:29952." [PRO:DAN] comment: Category=organism-modification. synonym: "hTGFB1/var:C225R/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P01137, 30-390, Cys-225, CHEBI:29952" EXACT PRO-proteoform-std [PRO:DAN] synonym: "TGF-beta 1 sequence variant 6, signal peptide removed form (human)" EXACT [PRO:DNx] intersection_of: PR:000000403 ! TGF-beta 1 sequence variant C225R (human) intersection_of: lacks_part SO:0000418 ! signal_peptide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000021907 name: TGF-beta 1 sequence variant R218H, signal peptide removed form (human) def: "A TGF-beta 1 sequence variant R218H (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Arg-218, CHEBI:29979." [PRO:DAN] comment: Category=organism-modification. synonym: "hTGFB1/var:R218H/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P01137, 30-390, Arg-218, CHEBI:29979" EXACT PRO-proteoform-std [PRO:DAN] synonym: "TGF-beta 1 sequence variant 4, signal peptide removed form (human)" EXACT [PRO:DNx] intersection_of: PR:000000401 ! TGF-beta 1 sequence variant R218H (human) intersection_of: lacks_part SO:0000418 ! signal_peptide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000021903 name: TGF-beta 1 sequence variant T81H, signal peptide removed form (human) def: "A TGF-beta 1 sequence variant T81H (human) that has had the signal peptide removed. UniProtKB:P01137, 30-390, Tyr-81, CHEBI:29979." [PRO:DAN] comment: Category=organism-modification. synonym: "hTGFB1/var:T81H/SigPep-" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P01137, 30-390, Tyr-81, CHEBI:29979" EXACT PRO-proteoform-std [PRO:DAN] synonym: "TGF-beta 1 sequence variant 2, signal peptide removed form (human)" EXACT [PRO:DNx] intersection_of: PR:000000399 ! TGF-beta 1 sequence variant T81H (human) intersection_of: lacks_part SO:0000418 ! signal_peptide relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P01137 name: transforming growth factor beta-1 (human) def: "A TGF-beta 1 that is encoded in the genome of human." [PRO:CNA, UniProtKB:P01137] comment: Category=organism-gene. synonym: "TGFB" RELATED Gene-based [UniProtKB:P01137] synonym: "TGFB1" RELATED Gene-based [UniProtKB:P01137] synonym: "hTGFB1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P01137 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000182 ! TGF-beta 1 relationship: has_gene_template HGNC:11766 ! TGFB1 (human) [Term] id: PR:000036529 name: TGF-beta 1 isoform 1 inactive form (mouse) def: "A TGF-beta 1 isoform 1 inactive form in mouse, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P04202-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1821856, PMID:9008713, PRO:CNA, PRO:DAN] comment: Category=organism-modification. Position information for the glycosylation site has Evidence=(ECO:0005560, based on PR:000026335). synonym: "mTGFB1/iso:1/inactive" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000033766, PRO_0000033767, Asn-82, MOD:00160" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P04202-1, 30-278, 279-390, Asn-82, MOD:00160" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000618 ! TGF-beta 1 isoform 1 inactive form relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine [Term] id: PR:000036526 name: TGF-beta 1 isoform 1 latency associated peptide (human) def: "A TGF-beta 1 isoform 1 latency associated peptide in human. UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:17015622, PMID:3162913, PRO:CNA, PRO:DAN] comment: Category=organism-modification. synonym: "hTGFB1/iso:1/LAP" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000617 ! TGF-beta 1 isoform 1 latency associated peptide relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine [Term] id: PR:000036527 name: TGF-beta 1 isoform 1 inactive form (green monkey) def: "A TGF-beta 1 isoform 1 inactive form in green monkey, in which the cleaved parts remain joined by disulfide bonds. UniProtKB:P09533-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:1448117, PMID:2677679, PRO:CNA, PRO:DAN] comment: Category=organism-modification. synonym: "GrMonkey-TGFB1/iso:1/inactive" EXACT PRO-short-label [PRO:DNx] synonym: "PRO_0000033760, PRO_0000033761, Asn-82, MOD:00160" EXACT PRO-proteoform-ftid [PRO:DNx] synonym: "UniProtKB:P09533-1, 30-278, 279-390, Asn-82, MOD:00160" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9534 ! Chlorocebus aethiops intersection_of: PR:000000618 ! TGF-beta 1 isoform 1 inactive form relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine [Term] id: PR:P17246 name: transforming growth factor beta-1 (rat) def: "A TGF-beta 1 that is encoded in the genome of rat." [OMA:P17246, PRO:DNx] comment: Category=organism-gene. synonym: "Tgfb1" RELATED Gene-based [UniProtKB:P17246] synonym: "rTGFB1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P17246 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000000182 ! TGF-beta 1 relationship: has_gene_template RGD:69051 ! Tgfb1 (rat) [Term] id: PR:000000619 name: TGF-beta 1 sequence variant T81H cleaved 1 (human) def: "A TGF-beta 1 sequence variant T81H, signal peptide removed form (human) that has been processed by subsequent removal of the latency associated peptide (LAP). UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979." [PMID:12493741, PRO:CNA, PRO:DAN] comment: Category=organism-modification. synonym: "hTGFB1/var:T81H/Clv:1" EXACT PRO-short-label [PRO:DAN] synonym: "UniProtKB:P01137, 279-390, Tyr-81, CHEBI:29979" EXACT PRO-proteoform-std [PRO:DAN] synonym: "TGF-beta 1 sequence variant 2 cleaved 1 (human)" EXACT [PRO:DAN] is_a: PR:000021903 ! TGF-beta 1 sequence variant T81H, signal peptide removed form (human) relationship: output_of GO:0016485 ! protein processing relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000000618 name: TGF-beta 1 isoform 1 inactive form def: "A TGF-beta 1 isoform 1, signal peptide removed form that has been cleaved at the dibasic cleavage site, rendering the latency associated peptide (LAP) and the mature protein non-covalently bound. This form is glycosylated mainly at either one or the two first consensus glycosylation sites within the LAP sequence. Example: UniProtKB:P01137-1, 30-278, 279-390, Asn-82, MOD:00160." [PMID:3162913, PMID:3185545, PRO:CNA, PRO:DAN] comment: Category=modification. synonym: "TGFb latent complex" RELATED [] synonym: "TGFB1/iso:1/inactive" EXACT PRO-short-label [PRO:DNx] synonym: "TGF beta latent complex" RELATED [] is_a: PR:000025454 ! TGF-beta 1 isoform 1, signal peptide removed form relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine [Term] id: PR:P09533 name: transforming growth factor beta-1 (green monkey) def: "A TGF-beta 1 that is encoded in the genome of green monkey." [PRO:DAN, UniProtKB:P09533] comment: Category=organism-gene. synonym: "TGFB1" RELATED Gene-based [UniProtKB:P09533] synonym: "GrMonkey-TGFB1" EXACT PRO-short-label [PRO:DAN] xref: UniProtKB:P09533 intersection_of: only_in_taxon NCBITaxon:9534 ! Chlorocebus aethiops intersection_of: PR:000000182 ! TGF-beta 1 [Term] id: PR:000025454 name: TGF-beta 1 isoform 1, signal peptide removed form def: "A TGF-beta 1 isoform 1 that has had the signal peptide removed." [PRO:DAN] comment: Category=modification. synonym: "TGFB1/iso:1/SigPep-" EXACT PRO-short-label [PRO:DNx] intersection_of: PR:000000397 ! TGF-beta 1 isoform 1 intersection_of: lacks_part SO:0000418 ! signal_peptide [Term] id: PR:P04202-1 name: transforming growth factor beta-1 isoform 1 (mouse) def: "A TGF-beta 1 isoform 1 that is encoded in the genome of mouse." [PRO:CNA] comment: Category=organism-sequence. synonym: "mTGFB1/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P04202-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000397 ! TGF-beta 1 isoform 1 [Term] id: PR:000000617 name: TGF-beta 1 isoform 1 latency associated peptide def: "A TGF-beta 1 isoform 1, signal peptide removed form that has had the C-terminal mature peptide removed and has been N-glycosylated mainly at either one of the two first consensus N-glycosylation sites. Example: UniProtKB:P01137-1, 30-279, Asn-82, MOD:00160." [PMID:3162913, PRO:CNA, PRO:DAN] comment: Category=modification. synonym: "LAP" RELATED [] synonym: "TGFB1/iso:1/LAP" EXACT PRO-short-label [PRO:DNx] synonym: "latent associated peptide" RELATED [] is_a: PR:000025454 ! TGF-beta 1 isoform 1, signal peptide removed form relationship: output_of GO:0016485 ! protein processing relationship: has_part MOD:00160 ! N4-glycosyl-L-asparagine [Term] id: PR:000000616 name: TGF-beta 1 isoform 1 mature form def: "A TGF-beta 1 isoform 1 that has been processed by proteolytic cleavage and released from the latent complex. This form is the active mature protein. Example: UniProtKB:P01137-1, 279-390." [PMID:3162913, PRO:CNA, PRO:DAN] comment: Category=modification. synonym: "TGFB1/iso:1/mature" EXACT PRO-short-label [PRO:DNx] synonym: "TGF-beta 1 active protein" RELATED [] synonym: "TGF-beta 1 mature protein" RELATED [] is_a: PR:000000397 ! TGF-beta 1 isoform 1 relationship: output_of GO:0016485 ! protein processing