[Term] id: PR:000000307 name: Rho-associated protein kinase 1 isoform 1 def: "A Rho-associated protein kinase 1 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q13464-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] comment: Category=sequence. Note: In resting cells, the C-terminal Rho-binding and PH domain mask the protein kinase catalytic domain, activation occurs through a conformational change. synonym: "ROCK1/iso:1" EXACT PRO-short-label [PRO:DNx] synonym: "ROCK1 sequence 1" EXACT [] is_a: PR:000000120 ! Rho-associated protein kinase 1