[Term] id: PR:000000657 name: smad3 isoform 1 acetylated and phosphorylated 1 def: "A smad3 isoform 1 acetylated and phosphorylated form in which the phosphorylation occurs upon TGF-beta receptor activation and which has been further acetylated at a Lys residue within the MH1 domain by coactivators, such as CBP and EP300. Example: UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046." [PMID:17074756] comment: Category=modification. synonym: "SMAD3/iso:1/AcPhos:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000577 ! smad3 isoform 1 acetylated and phosphorylated form relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00064 ! N6-acetyl-L-lysine [Term] id: PR:000000577 name: smad3 isoform 1 acetylated and phosphorylated form def: "A smad3 isoform 1 that includes at least one acetylated residue and at least one phosphorylated residue." [PRO:CNA] comment: Category=modification. synonym: "SMAD3/iso:1/AcPhos+" EXACT PRO-short-label [PRO:DNx] intersection_of: has_part MOD:00394 ! acetylated residue intersection_of: has_part MOD:00696 ! phosphorylated residue intersection_of: PR:000000475 ! smad3 isoform 1 [Term] id: PR:000000578 name: smad3 isoform 1 phosphorylated form def: "A smad3 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA] comment: Category=modification. synonym: "SMAD3/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx] intersection_of: has_part MOD:00696 ! phosphorylated residue intersection_of: PR:000000475 ! smad3 isoform 1 [Term] id: PR:Q8BUN5-1 name: mothers against decapentaplegic homolog 3 isoform 1 (mouse) def: "A smad3 isoform 1 that is encoded in the genome of mouse." [PRO:CNA] comment: Category=organism-sequence. synonym: "mSMAD3/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:Q8BUN5-1 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000475 ! smad3 isoform 1 [Term] id: PR:000000659 name: smad3 isoform 1 phosphorylated 2 def: "A smad3 isoform 1 phosphorylated form in which the phosphorylation occurs at the N-terminal Px[ST]P motif and the clusters of [ST]P motifs within the MH1-MH2 domain linker region by G1 cyclin-dependent kinases (CDK4 and CDK2) leading to CDK inhibition of its transcriptional activity and antiproliferative function. Example: UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046." [PMID:15241418, PRO:CNA, PRO:DAN] comment: Category=modification. synonym: "SMAD3/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000578 ! smad3 isoform 1 phosphorylated form relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000000658 name: smad3 isoform 1 phosphorylated 1 def: "A smad3 isoform 1 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif as a result of the activation of the transforming growth factor beta signaling pathway. Example: UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046." [PMID:8774881] comment: Category=modification. synonym: "smad3 active" EXACT [] synonym: "SMAD3/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "TGF-beta receptor-activated smad3" RELATED [] is_a: PR:000000578 ! smad3 isoform 1 phosphorylated form relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000026333 name: smad3 isoform 1 phosphorylated 1 (human) def: "A smad3 isoform 1 phosphorylated 1 in human. UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046." [PRO:DNx, UniProtKB:P84022] comment: Category=organism-modification. synonym: "hSMAD3/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P84022-1, Ser-423/Ser-425, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000658 ! smad3 isoform 1 phosphorylated 1 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:P84022-1 name: mothers against decapentaplegic homolog 3 isoform 1 (human) def: "A smad3 isoform 1 that is encoded in the genome of human." [PRO:CNA] comment: Category=organism-sequence. Requested by=PubChem. synonym: "hSMAD3/iso:1" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P84022-1 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000475 ! smad3 isoform 1 [Term] id: PR:P84022-2 name: mothers against decapentaplegic homolog 3 isoform h2 (human) def: "A mothers against decapentaplegic homolog 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P84022-2." [PRO:DNx, UniProtKB:P84022] comment: Category=organism-sequence. synonym: "hSMAD3/iso:h2" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P84022-2 is_a: PR:P84022 ! mothers against decapentaplegic homolog 3 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P84022-3 name: mothers against decapentaplegic homolog 3 isoform h3 (human) def: "A mothers against decapentaplegic homolog 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P84022-3." [PRO:DNx, UniProtKB:P84022] comment: Category=organism-sequence. synonym: "hSMAD3/iso:h3" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P84022-3 is_a: PR:P84022 ! mothers against decapentaplegic homolog 3 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P84022-4 name: mothers against decapentaplegic homolog 3 isoform h4 (human) def: "A mothers against decapentaplegic homolog 3 (human) that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P84022-4." [PRO:DNx, UniProtKB:P84022] comment: Category=organism-sequence. synonym: "hSMAD3/iso:h4" EXACT PRO-short-label [PRO:DNx] xref: UniProtKB:P84022-4 is_a: PR:P84022 ! mothers against decapentaplegic homolog 3 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P84025 name: mothers against decapentaplegic homolog 3 (rat) def: "A smad3 that is encoded in the genome of rat." [OMA:P84025, PRO:DNx] comment: Category=organism-gene. synonym: "Madh3" RELATED Gene-based [UniProtKB:P84025] synonym: "Smad3" RELATED Gene-based [UniProtKB:P84025] synonym: "rSMAD3" EXACT PRO-short-label [PRO:DNx] synonym: "Mad3 (rat)" RELATED [UniProtKB:P84025] synonym: "SMAD 3 (rat)" EXACT [UniProtKB:P84025] synonym: "MAD homolog 3 (rat)" EXACT [UniProtKB:P84025] synonym: "SMAD family member 3 (rat)" EXACT [UniProtKB:P84025] synonym: "mothers against DPP homolog 3 (rat)" EXACT [UniProtKB:P84025] xref: UniProtKB:P84025 intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus intersection_of: PR:000000365 ! smad3 relationship: has_gene_template RGD:3032 ! Smad3 (rat) [Term] id: PR:000036558 name: smad3 isoform 1 phosphorylated 1 (mouse) def: "A smad3 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q8BUN5-1, Ser-423/Ser-425, MOD:00046." [PMID:10823886, PMID:12943993, PMID:15282343, PMID:15464984, PMID:9702197, PRO:CNA] comment: Category=organism-modification. synonym: "mSMAD3/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q8BUN5-1, Ser-423/Ser-425, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000658 ! smad3 isoform 1 phosphorylated 1 relationship: has_part MOD:00046 ! O-phospho-L-serine [Term] id: PR:000036557 name: smad3 isoform 1 acetylated and phosphorylated 1 (human) def: "A smad3 isoform 1 acetylated and phosphorylated 1 in human. UniProtKB:P84022-1, Lys-19, MOD:00064|Ser-423/Ser-425, MOD:00046." [PMID:17074756, PRO:CNA] comment: Category=organism-modification. synonym: "hSMAD3/iso:1/AcPhos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P84022-1, Lys-19, MOD:00394|Ser-423/Ser-425, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000657 ! smad3 isoform 1 acetylated and phosphorylated 1 relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00064 ! N6-acetyl-L-lysine [Term] id: PR:000049285 name: mothers against decapentaplegic homolog 3 phosphorylated 1 (human) def: "A mothers against decapentaplegic homolog 3 (human) that has been post-translationally modified to include phosphoserine at positions 423 and 425 of the amino acid sequence represented by UniProtKB:P84022. UniProtKB:P84022, Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-171184, Reactome:R-HSA-177104] comment: Category=organism-modification. synonym: "hSMAD3/Phos:1" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P84022, Ser-423/Ser-425, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-171184 "PR:000049285 located_in GO:0005829" xref: Reactome:R-HSA-177104 "PR:000049285 located_in GO:0005654" is_a: PR:P84022 ! mothers against decapentaplegic homolog 3 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049287 name: mothers against decapentaplegic homolog 3 ubiquitinated form (human) def: "A mothers against decapentaplegic homolog 3 (human) that includes at least one ubiquitinated lysine. UniProtKB:P84022, MOD:01148." [PRO:DNx, Reactome:R-HSA-6782830] comment: Category=organism-modification. synonym: "hSMAD3/UbiqLys+" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P84022, MOD:01148" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-6782830 "PR:000049287 located_in GO:0005829" intersection_of: has_part MOD:01148 ! ubiquitinylated lysine intersection_of: PR:P84022 ! mothers against decapentaplegic homolog 3 (human) relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:000049286 name: mothers against decapentaplegic homolog 3 phosphorylated 2 (human) def: "A mothers against decapentaplegic homolog 3 (human) that has been phosphorylated on the residue at the position equivalent to Thr-179, and phosphoserine at positions 423 and 425 of the amino acid sequence represented by UniProtKB:P84022. UniProtKB:P84022, Thr-179, MOD:00047|Ser-423/Ser-425, MOD:00046." [PRO:DNx, Reactome:R-HSA-2176471] comment: Category=organism-modification. synonym: "hSMAD3/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:P84022, Thr-179, MOD:00047|Ser-423/Ser-425, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx] xref: Reactome:R-HSA-2176471 "PR:000049286 located_in GO:0005654" is_a: PR:P84022 ! mothers against decapentaplegic homolog 3 (human) relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens [Term] id: PR:P84023 name: mothers against decapentaplegic homolog 3 (chicken) def: "A smad3 that is encoded in the genome of chicken." [OMA:P84023, PRO:DNx] comment: Category=organism-gene. synonym: "MADH3" RELATED Gene-based [UniProtKB:P84023] synonym: "SMAD3" RELATED Gene-based [UniProtKB:P84023] synonym: "chick-SMAD3" EXACT PRO-short-label [PRO:DNx] synonym: "Mad3 (chicken)" EXACT [UniProtKB:P84023] synonym: "Smad3 (chicken)" EXACT [UniProtKB:P84023] synonym: "SMAD 3 (chicken)" EXACT [UniProtKB:P84023] synonym: "MAD homolog 3 (chicken)" EXACT [UniProtKB:P84023] synonym: "SMAD family member 3 (chicken)" EXACT [UniProtKB:P84023] synonym: "mothers against DPP homolog 3 (chicken)" EXACT [UniProtKB:P84023] xref: UniProtKB:P84023 intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus intersection_of: PR:000000365 ! smad3 relationship: has_gene_template NCBIGene:395132 ! SMAD3 (chicken) [Term] id: PR:P84022 name: mothers against decapentaplegic homolog 3 (human) def: "A smad3 that is encoded in the genome of human." [] comment: Category=organism-gene. synonym: "MADH3" RELATED Gene-based [UniProtKB:P84022] synonym: "SMAD3" RELATED Gene-based [UniProtKB:P84022] synonym: "hMAD-3" EXACT [UniProtKB:P84022] synonym: "hSMAD3" EXACT PRO-short-label [PRO:DNx] synonym: "Mad3 (human)" EXACT [UniProtKB:P84022] synonym: "Smad3 (human)" EXACT [UniProtKB:P84022] synonym: "JV15-2 (human)" EXACT [UniProtKB:P84022] synonym: "SMAD 3 (human)" EXACT [UniProtKB:P84022] synonym: "MAD homolog 3 (human)" EXACT [UniProtKB:P84022] synonym: "SMAD family member 3 (human)" EXACT [UniProtKB:P84022] synonym: "mothers against DPP homolog 3 (human)" EXACT [UniProtKB:P84022] xref: Reactome:R-HSA-206150 "PR:P84022 located_in GO:0005654" xref: Reactome:R-HSA-170855 "PR:P84022 located_in GO:0005829" xref: UniProtKB:P84022 intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens intersection_of: PR:000000365 ! smad3 relationship: has_gene_template HGNC:6769 ! SMAD3 (human) [Term] id: PR:000000660 name: smad3 isoform 1 phosphorylated 3 def: "A smad3 isoform 1 phosphorylated form in which the phosphorylation occurs at the clusters of [S/T]P motifs within the MH1-MH2 domain linker region through the MAP kinase cascade in oncogenic Ras-activated pathway. Example: UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046." [PMID:10197981, PRO:CNA, PRO:DAN] comment: Category=modification. Note: TGF-receptor phosphorylation sites are not required for Ras-induced phosphorylation. synonym: "SMAD3/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000578 ! smad3 isoform 1 phosphorylated form relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000000365 name: smad3 def: "A TGF-beta receptor-regulated smad protein that is a translation product of the human SMAD3 gene or a 1:1 ortholog thereof." [PMID:9311995] comment: Category=gene. synonym: "mad3" EXACT [] synonym: "MAD-3" EXACT [] synonym: "MADH3" RELATED Gene-based [] synonym: "SMAD3" EXACT PRO-short-label [PRO:DNx] synonym: "JV15-2" EXACT [] synonym: "SMAD 3" EXACT [] synonym: "MAD homolog 3" EXACT [] synonym: "SMAD family member 3" EXACT [] synonym: "mothers against DPP homolog 3" EXACT [] is_a: PR:000000066 ! TGF-beta receptor-regulated smad protein [Term] id: PR:Q8BUN5 name: mothers against decapentaplegic homolog 3 (mouse) def: "A smad3 that is encoded in the genome of mouse." [OMA:Q8BUN5, PRO:DNx] comment: Category=organism-gene. synonym: "Madh3" RELATED Gene-based [UniProtKB:Q8BUN5] synonym: "Smad3" RELATED Gene-based [UniProtKB:Q8BUN5] synonym: "mMad3" EXACT [UniProtKB:Q8BUN5] synonym: "mSMAD3" EXACT PRO-short-label [PRO:DNx] synonym: "Mad3 (mouse)" RELATED [UniProtKB:Q8BUN5] synonym: "SMAD 3 (mouse)" EXACT [UniProtKB:Q8BUN5] synonym: "MAD homolog 3 (mouse)" EXACT [UniProtKB:Q8BUN5] synonym: "SMAD family member 3 (mouse)" EXACT [UniProtKB:Q8BUN5] synonym: "mothers against DPP homolog 3 (mouse)" EXACT [UniProtKB:Q8BUN5] xref: UniProtKB:Q8BUN5 intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000365 ! smad3 relationship: has_gene_template MGI:1201674 ! Smad3 (mouse) [Term] id: PR:000036560 name: smad3 isoform 1 phosphorylated 2 (mouse) def: "A smad3 isoform 1 phosphorylated 2 in mouse. UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046." [PMID:15241418, PRO:CNA, PRO:DAN] comment: Category=organism-modification. Note: The modified sites indicated here (Thr-8/Thr-179/Ser-213) are referred to as Thr-8/Thr-178/Ser-212 in some manuscripts. [PRO:DAN, PMID:15241418] synonym: "mSMAD3/iso:1/Phos:2" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q8BUN5-1, Thr-8/Thr-179, MOD:00047|Ser-213, MOD:00046" EXACT PRO-proteoform-std [PRO:DAN] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000659 ! smad3 isoform 1 phosphorylated 2 relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000036561 name: smad3 isoform 1 phosphorylated 3 (mouse) def: "A smad3 isoform 1 phosphorylated 3 in mouse. UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046." [PMID:10197981, PRO:CNA, PRO:DAN] comment: Category=organism-modification. Note: The modified sites indicated here (Thr-179/Ser-204/Ser-208/Ser-213) are referred to as Thr-178/Ser-203/Ser-207/Ser-212 in some manuscripts. [PRO:DAN, PMID:10197981] synonym: "mSMAD3/iso:1/Phos:3" EXACT PRO-short-label [PRO:DNx] synonym: "UniProtKB:Q8BUN5-1, Thr-179, MOD:00047|Ser-204/Ser-208/Ser-213, MOD:00046" EXACT PRO-proteoform-std [PRO:DAN] intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus intersection_of: PR:000000660 ! smad3 isoform 1 phosphorylated 3 relationship: has_part MOD:00046 ! O-phospho-L-serine relationship: has_part MOD:00047 ! O-phospho-L-threonine [Term] id: PR:000000475 name: smad3 isoform 1 def: "A smad3 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:P84022-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN] comment: Category=sequence. synonym: "SMAD3/iso:1" EXACT PRO-short-label [PRO:DNx] is_a: PR:000000365 ! smad3