[Term]
id: PR:Q56I99
name: mothers against decapentaplegic homolog 5 (chicken)
def: "A smad5 that is encoded in the genome of chicken." [OMA:Q56I99, PRO:DNx, UniProtKB:Q56I99]
comment: Category=organism-gene.
synonym: "MADH5" RELATED Gene-based [UniProtKB:Q56I99]
synonym: "SMAD5" RELATED Gene-based [UniProtKB:Q56I99]
synonym: "chick-SMAD5" EXACT PRO-short-label [PRO:DNx]
synonym: "Smad5 (chicken)" EXACT [UniProtKB:Q56I99]
synonym: "SMAD 5 (chicken)" EXACT [UniProtKB:Q56I99]
synonym: "MAD homolog 5 (chicken)" EXACT [UniProtKB:Q56I99]
synonym: "SMAD family member 5 (chicken)" EXACT [UniProtKB:Q56I99]
synonym: "mothers against DPP homolog 5 (chicken)" EXACT [UniProtKB:Q56I99]
xref: UniProtKB:Q56I99
intersection_of: only_in_taxon NCBITaxon:9031 ! Gallus gallus
intersection_of: PR:000000372 ! smad5
relationship: has_gene_template CGNC:4741 ! SMAD5 (chicken)

[Term]
id: PR:000029962
name: smad5 isoform 2 (human)
def: "A smad5 isoform 2 that is encoded in the genome of human." [PRO:DAN]
comment: Category=organism-sequence. Note: There is no sequence deposited in any database for this form.
synonym: "hSMAD5/iso:2" EXACT PRO-short-label [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000478 ! smad5 isoform 2

[Term]
id: PR:Q9R1V3
name: mothers against decapentaplegic homolog 5 (rat)
def: "A smad5 that is encoded in the genome of rat." [OMA:Q9R1V3, PRO:DNx]
comment: Category=organism-gene.
synonym: "Madh5" RELATED Gene-based [UniProtKB:Q9R1V3]
synonym: "Smad5" RELATED Gene-based [UniProtKB:Q9R1V3]
synonym: "rSMAD5" EXACT PRO-short-label [PRO:DNx]
synonym: "SMAD 5 (rat)" EXACT [UniProtKB:Q9R1V3]
synonym: "MAD homolog 5 (rat)" EXACT [UniProtKB:Q9R1V3]
synonym: "SMAD family member 5 (rat)" EXACT [UniProtKB:Q9R1V3]
synonym: "mothers against DPP homolog 5 (rat)" EXACT [UniProtKB:Q9R1V3]
xref: UniProtKB:Q9R1V3
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000372 ! smad5
relationship: has_gene_template RGD:620158 ! Smad5 (rat)

[Term]
id: PR:Q9W7E7
name: mothers against decapentaplegic homolog 5 (zebrafish)
def: "A smad5 that is encoded in the genome of zebrafish." [OMA:Q9W7E7, PRO:DNx]
comment: Category=organism-gene.
synonym: "sbn" RELATED Gene-based [UniProtKB:Q9W7E7]
synonym: "madh5" RELATED Gene-based [UniProtKB:Q9W7E7]
synonym: "smad5" RELATED Gene-based [UniProtKB:Q9W7E7]
synonym: "z-SMAD5" EXACT PRO-short-label [PRO:DNx]
synonym: "Smad5 (zebrafish)" EXACT [UniProtKB:Q9W7E7]
synonym: "SMAD 5 (zebrafish)" EXACT [UniProtKB:Q9W7E7]
synonym: "MAD homolog 5 (zebrafish)" EXACT [UniProtKB:Q9W7E7]
synonym: "protein somitabun (zebrafish)" EXACT [UniProtKB:Q9W7E7]
synonym: "SMAD family member 5 (zebrafish)" EXACT [UniProtKB:Q9W7E7]
synonym: "mothers against DPP homolog 5 (zebrafish)" EXACT [UniProtKB:Q9W7E7]
xref: UniProtKB:Q9W7E7
intersection_of: only_in_taxon NCBITaxon:7955 ! Danio rerio
intersection_of: PR:000000372 ! smad5
relationship: has_gene_template ZFIN:ZDB-GENE-990603-9 ! smad5 (zebrafish)

[Term]
id: PR:000049290
name: mothers against decapentaplegic homolog 5, initiator methionine removed phosphorylated 1 (human)
def: "A mothers against decapentaplegic homolog 5 (human) that has had the initiator methionine removed and has been post-translationally modified to include phosphoserine at positions 463 and 465 of the amino acid sequence represented by UniProtKB:Q99717. UniProtKB:Q99717, 2-465, Ser-463/Ser-465, MOD:00046." [PRO:DNx, Reactome:R-HSA-201432, Reactome:R-HSA-201473]
comment: Category=organism-modification.
synonym: "hSMAD5/InitMet-/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "PRO_0000090865, Ser-463/Ser-465, MOD:00046" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "UniProtKB:Q99717, 2-465, Ser-463/Ser-465, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-201432 "PR:000049290 located_in GO:0005654"
xref: Reactome:R-HSA-201473 "PR:000049290 located_in GO:0005829"
is_a: PR:Q99717 ! mothers against decapentaplegic homolog 5 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000049289
name: mothers against decapentaplegic homolog 5, initiator methionine removed form (human)
def: "A mothers against decapentaplegic homolog 5 (human) that has had the initiator methionine removed. UniProtKB:Q99717, 2-465." [PRO:DNx, Reactome:R-HSA-201431]
comment: Category=organism-modification.
synonym: "PRO_0000090865" EXACT PRO-proteoform-ftid [PRO:DNx]
synonym: "hSMAD5/InitMet-" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q99717, 2-465" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-201431 "PR:000049289 located_in GO:0005829"
intersection_of: lacks_part PR:000021937 ! initiator methionine
intersection_of: PR:Q99717 ! mothers against decapentaplegic homolog 5 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000580
name: smad5 isoform 1 phosphorylated form
def: "A smad5 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "SMAD5/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000000477 ! smad5 isoform 1

[Term]
id: PR:P97454
name: mothers against decapentaplegic homolog 5 (mouse)
def: "A smad5 that is encoded in the genome of mouse." [OMA:P97454, PRO:DNx]
comment: Category=organism-gene.
synonym: "Madh5" RELATED Gene-based [UniProtKB:P97454]
synonym: "Smad5" RELATED Gene-based [UniProtKB:P97454]
synonym: "Msmad5" RELATED Gene-based [UniProtKB:P97454]
synonym: "mSMAD5" EXACT PRO-short-label [PRO:DNx]
synonym: "mSmad5" EXACT [UniProtKB:P97454]
synonym: "Dwf-C (mouse)" EXACT [UniProtKB:P97454]
synonym: "SMAD 5 (mouse)" EXACT [UniProtKB:P97454]
synonym: "dwarfin-C (mouse)" EXACT [UniProtKB:P97454]
synonym: "MAD homolog 5 (mouse)" EXACT [UniProtKB:P97454]
synonym: "SMAD family member 5 (mouse)" EXACT [UniProtKB:P97454]
synonym: "mothers against DPP homolog 5 (mouse)" EXACT [UniProtKB:P97454]
xref: UniProtKB:P97454
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000372 ! smad5
relationship: has_gene_template MGI:1328787 ! Smad5 (mouse)

[Term]
id: PR:000018297
name: smad5, initiator methionine removed form
def: "A smad5 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "SMAD5/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000000372 ! smad5
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000000478
name: smad5 isoform 2
def: "A smad5 that is a translation product of a transcript comprising intron 6 generating a C-terminus truncated MH2 domain and a unique C-terminus sequence lacking the SSxS motif necessary for SMAD activation." [EST:AA169504, PMID:10845932, PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "smad5 beta" RELATED []
synonym: "SMAD5/iso:2" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000372 ! smad5

[Term]
id: PR:P97454-1
name: mothers against decapentaplegic homolog 5 isoform 1 (mouse)
def: "A smad5 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mSMAD5/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:P97454-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000477 ! smad5 isoform 1

[Term]
id: PR:000036562
name: smad5 isoform 1 phosphorylated 1 (human)
def: "A smad5 isoform 1 phosphorylated 1 in human. UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046." [PMID:8637600, PMID:8673135, PRO:CNA]
comment: Category=organism-modification.
synonym: "hSMAD5/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000661 ! smad5 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000000661
name: smad5 isoform 1 phosphorylated 1
def: "A smad5 isoform 1 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif as a result of the activation of the bone morphogenetic protein (BMP) signaling pathway. Example: UniProtKB:Q99717-1, Ser-463/Ser-465, MOD:00046." [PMID:8637600]
comment: Category=modification.
synonym: "SMAD5/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000580 ! smad5 isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:Q99717
name: mothers against decapentaplegic homolog 5 (human)
def: "A smad5 that is encoded in the genome of human." []
comment: Category=organism-gene.
synonym: "MADH5" RELATED Gene-based [UniProtKB:Q99717]
synonym: "SMAD5" RELATED Gene-based [UniProtKB:Q99717]
synonym: "hSMAD5" EXACT PRO-short-label [PRO:DNx]
synonym: "hSmad5" EXACT [UniProtKB:Q99717]
synonym: "JV5-1 (human)" EXACT [UniProtKB:Q99717]
synonym: "Smad5 (human)" EXACT [UniProtKB:Q99717]
synonym: "SMAD 5 (human)" EXACT [UniProtKB:Q99717]
synonym: "MAD homolog 5 (human)" EXACT [UniProtKB:Q99717]
synonym: "SMAD family member 5 (human)" EXACT [UniProtKB:Q99717]
synonym: "mothers against DPP homolog 5 (human)" EXACT [UniProtKB:Q99717]
xref: UniProtKB:Q99717
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000372 ! smad5
relationship: has_gene_template HGNC:6771 ! SMAD5 (human)

[Term]
id: PR:000000372
name: smad5
def: "A BMP receptor-regulated smad protein that is a translation product of the human SMAD5 gene or a 1:1 ortholog thereof." [PMID:10708949]
comment: Category=gene.
synonym: "Dwf-C" EXACT []
synonym: "JV5-1" EXACT []
synonym: "MADH5" RELATED Gene-based []
synonym: "SMAD5" EXACT PRO-short-label [PRO:DNx]
synonym: "Smad5" EXACT []
synonym: "SMAD 5" EXACT []
synonym: "dwarfin-C" EXACT []
synonym: "MAD homolog 5" EXACT []
synonym: "SMAD family member 5" EXACT []
synonym: "mothers against DPP homolog 5" EXACT []
is_a: PR:000000038 ! BMP receptor-regulated smad protein

[Term]
id: PR:000036563
name: smad5 isoform 1 phosphorylated 1 (mouse)
def: "A smad5 isoform 1 phosphorylated 1 in mouse. UniProtKB:P97454-1, Ser-463/Ser-465, MOD:00046." [PMID:10504300, PMID:15331632, PMID:16522160, PMID:9759503, PRO:CNA]
comment: Category=organism-modification.
synonym: "mSMAD5/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:P97454-1, Ser-463/Ser-465, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000661 ! smad5 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000026652
name: smad5 isoform 1, initiator methionine removed form
def: "A smad5 isoform 1 that has had the initiator methionine removed." [PRO:DNx]
comment: Category=modification.
synonym: "SMAD5/iso:1/InitMet-" EXACT PRO-short-label [PRO:DNx]
intersection_of: PR:000000477 ! smad5 isoform 1
intersection_of: lacks_part PR:000021937 ! initiator methionine

[Term]
id: PR:000000477
name: smad5 isoform 1
def: "A smad5 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q99717-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "SMAD5/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000372 ! smad5

[Term]
id: PR:Q99717-1
name: mothers against decapentaplegic homolog 5 isoform 1 (human)
def: "A smad5 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSMAD5/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q99717-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000477 ! smad5 isoform 1