[Term]
id: PR:000000373
name: smad6
def: "An inhibitory smad protein that is a translation product of the human SMAD6 gene or a 1:1 ortholog thereof. Inhibitor of bone morphogenetic protein (BMP) signaling, and the interaction with BMP type 1 receptors is a critical step in the function of smad6." [PMID:17493940]
comment: Category=gene.
synonym: "MADH6" RELATED Gene-based []
synonym: "Madh7" RELATED Gene-based []
synonym: "SMAD6" EXACT PRO-short-label [PRO:DNx]
synonym: "Msmad6" RELATED Gene-based []
synonym: "SMAD 6" EXACT []
synonym: "MAD homolog 6" EXACT []
synonym: "Mad homolog 7" EXACT []
synonym: "SMAD family member 6" EXACT []
synonym: "mothers against DPP homolog 6" EXACT []
is_a: PR:000000099 ! inhibitory smad protein

[Term]
id: PR:O35182
name: mothers against decapentaplegic homolog 6 (mouse)
def: "A smad6 that is encoded in the genome of mouse." [OMA:O35182, PRO:DNx]
comment: Category=organism-gene.
synonym: "Madh6" RELATED Gene-based [UniProtKB:O35182]
synonym: "Madh7" RELATED Gene-based [UniProtKB:O35182]
synonym: "Smad6" RELATED Gene-based [UniProtKB:O35182]
synonym: "Msmad6" RELATED Gene-based [UniProtKB:O35182]
synonym: "mSMAD6" EXACT PRO-short-label [PRO:DNx]
synonym: "SMAD 6 (mouse)" EXACT [UniProtKB:O35182]
synonym: "MAD homolog 6 (mouse)" EXACT [UniProtKB:O35182]
synonym: "Mad homolog 7 (mouse)" EXACT [UniProtKB:O35182]
synonym: "SMAD family member 6 (mouse)" EXACT [UniProtKB:O35182]
synonym: "mothers against DPP homolog 6 (mouse)" EXACT [UniProtKB:O35182]
xref: UniProtKB:O35182
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000373 ! smad6
relationship: has_gene_template MGI:1336883 ! Smad6 (mouse)

[Term]
id: PR:O35182-1
name: mothers against decapentaplegic homolog 6 isoform 1 (mouse)
def: "A smad6 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mSMAD6/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O35182-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000479 ! smad6 isoform 1

[Term]
id: PR:000036564
name: smad6 isoform 1 dimethylated 1 (mouse)
def: "A smad6 isoform 1 dimethylated 1 in mouse. UniProtKB:O35182-1, Arg-74, MOD:00783." [PMID:17118358, PRO:CNA]
comment: Category=organism-modification.
synonym: "mSMAD6/iso:1/Me2:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O35182-1, Arg-74, MOD:00783" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000662 ! smad6 isoform 1 dimethylated 1
relationship: has_part MOD:00783 ! dimethylated L-arginine