[Term]
id: PR:000049291
name: mothers against decapentaplegic homolog 9 phosphorylated 1 (human)
def: "A mothers against decapentaplegic homolog 9 (human) that has been post-translationally modified to include phosphoserine at positions 465 and 467 of the amino acid sequence represented by UniProtKB:O15198. UniProtKB:O15198, Ser-465/Ser-467, MOD:00046." [PRO:DNx, Reactome:R-HSA-201441, Reactome:R-HSA-201474]
comment: Category=organism-modification.
synonym: "hSMAD9/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O15198, Ser-465/Ser-467, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
xref: Reactome:R-HSA-201441 "PR:000049291 located_in GO:0005829"
xref: Reactome:R-HSA-201474 "PR:000049291 located_in GO:0005654"
is_a: PR:O15198 ! mothers against decapentaplegic homolog 9 (human)
relationship: has_part MOD:00046 ! O-phospho-L-serine
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:O15198-1
name: mothers against decapentaplegic homolog 9 isoform A (human)
def: "A smad9 isoform 3 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSMAD9/iso:A" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O15198-1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000484 ! smad9 isoform 3

[Term]
id: PR:000029959
name: smad9 isoform 3 (human)
def: "A mothers against decapentaplegic homolog 9 (human) that is a translation product of a transcript that lacks the last exon." [PMID:10583507, PRO:DAN]
comment: Category=organism-sequence. Note: There is no sequence deposited in any database for this isoform. Lacks the C-terminal SSxS motif. Inhibits BMP signaling.
synonym: "hSMAD9/iso:3" EXACT PRO-short-label [PRO:DNx]
synonym: "SMAD8b (human)" RELATED []
is_a: PR:O15198 ! mothers against decapentaplegic homolog 9 (human)
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

[Term]
id: PR:000000667
name: smad9 isoform 3 phosphorylated 1
def: "A smad9 isoform 3 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif. Example: UniProtKB:O15198-1, Ser-465/Ser-467, MOD:00046." [PMID:17081983, PRO:CNA, PRO:DAN]
comment: Category=modification.
synonym: "SMAD9/iso:3/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000586 ! smad9 isoform 3 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000000585
name: smad9 isoform 1 phosphorylated form
def: "A smad9 isoform 1 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "SMAD9/iso:1/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000000482 ! smad9 isoform 1

[Term]
id: PR:000000666
name: smad9 isoform 1 phosphorylated 1
def: "A smad9 isoform 1 phosphorylated form in which the phosphorylation occurs at the C-terminal SSxS motif as a result of the activation of the bone morphogenetic protein (BMP) signaling pathway. Example: UniProtKB:Q9JIW5-1, Ser-428/Ser-430, MOD:00046." [PMID:15542835]
comment: Category=modification.
synonym: "phospho-R-smad9" RELATED []
synonym: "SMAD9/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000585 ! smad9 isoform 1 phosphorylated form
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000000586
name: smad9 isoform 3 phosphorylated form
def: "A smad9 isoform 3 that includes at least one phosphorylated residue." [PRO:CNA]
comment: Category=modification.
synonym: "SMAD9/iso:3/PhosRes+" EXACT PRO-short-label [PRO:DNx]
intersection_of: has_part MOD:00696 ! phosphorylated residue
intersection_of: PR:000000484 ! smad9 isoform 3

[Term]
id: PR:000036567
name: smad9 isoform 1 phosphorylated 1 (mouse)
def: "A smad9 isoform 1 phosphorylated 1 in mouse. UniProtKB:Q9JIW5-1, Ser-428/Ser-430, MOD:00046." [PMID:10814522, PMID:11163184, PMID:15542835, PRO:CNA]
comment: Category=organism-modification.
synonym: "mSMAD9/iso:1/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:Q9JIW5-1, Ser-428/Ser-430, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000666 ! smad9 isoform 1 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000000484
name: smad9 isoform 3
def: "A smad9 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:O15198-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "SMAD9/iso:3" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000375 ! smad9

[Term]
id: PR:O15198
name: mothers against decapentaplegic homolog 9 (human)
def: "A smad9 that is encoded in the genome of human." []
comment: Category=organism-gene.
synonym: "MADH6" RELATED Gene-based [UniProtKB:O15198]
synonym: "MADH9" RELATED Gene-based [UniProtKB:O15198]
synonym: "SMAD8" RELATED Gene-based [UniProtKB:O15198]
synonym: "SMAD9" RELATED Gene-based [UniProtKB:O15198]
synonym: "hSMAD9" EXACT PRO-short-label [PRO:DNx]
synonym: "Smad9 (human)" EXACT [UniProtKB:O15198]
synonym: "SMAD 9 (human)" EXACT [UniProtKB:O15198]
synonym: "MAD homolog 9 (human)" EXACT [UniProtKB:O15198]
synonym: "SMAD family member 9 (human)" EXACT [UniProtKB:O15198]
synonym: "mothers against DPP homolog 9 (human)" EXACT [UniProtKB:O15198]
xref: Reactome:R-HSA-201478 "PR:O15198 located_in GO:0005829"
xref: UniProtKB:O15198
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000375 ! smad9
relationship: has_gene_template HGNC:6774 ! SMAD9 (human)

[Term]
id: PR:O15198-2
name: mothers against decapentaplegic homolog 9 isoform B (human)
def: "A smad9 isoform 1 that is encoded in the genome of human." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "hSMAD9/iso:B" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:O15198-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000482 ! smad9 isoform 1

[Term]
id: PR:O54835
name: mothers against decapentaplegic homolog 9 (rat)
def: "A smad9 that is encoded in the genome of rat." [PRO:DNx, UniProtKB:O54835]
comment: Category=organism-gene.
synonym: "Madh8" RELATED Gene-based [UniProtKB:O54835]
synonym: "Madh9" RELATED Gene-based [UniProtKB:O54835]
synonym: "Smad8" RELATED Gene-based [UniProtKB:O54835]
synonym: "Smad9" RELATED Gene-based [UniProtKB:O54835]
synonym: "rSMAD9" EXACT PRO-short-label [PRO:DNx]
synonym: "SMAD 9 (rat)" EXACT [UniProtKB:O54835]
synonym: "MAD homolog 9 (rat)" EXACT [UniProtKB:O54835]
synonym: "SMAD family member 9 (rat)" EXACT [UniProtKB:O54835]
synonym: "mothers against DPP homolog 9 (rat)" EXACT [UniProtKB:O54835]
xref: UniProtKB:O54835
intersection_of: only_in_taxon NCBITaxon:10116 ! Rattus norvegicus
intersection_of: PR:000000375 ! smad9
relationship: has_gene_template RGD:71004 ! Smad9 (rat)

[Term]
id: PR:000000482
name: smad9 isoform 1
def: "A smad9 that is a translation product of some mRNA whose exon structure and start site selection renders it capable of giving rise to a protein with the amino acid sequence represented by UniProtKB:Q9JIW5-1 or a 1:1 ortholog thereof." [PRO:CNA, PRO:DAN]
comment: Category=sequence.
synonym: "MADH6b" RELATED []
synonym: "SMAD8a" RELATED []
synonym: "SMAD9/iso:1" EXACT PRO-short-label [PRO:DNx]
is_a: PR:000000375 ! smad9

[Term]
id: PR:Q9JIW5-1
name: mothers against decapentaplegic homolog 9 isoform 1 (mouse)
def: "A smad9 isoform 1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mSMAD9/iso:1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:Q9JIW5-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000482 ! smad9 isoform 1

[Term]
id: PR:Q9JIW5
name: mothers against decapentaplegic homolog 9 (mouse)
def: "A smad9 that is encoded in the genome of mouse." [OMA:Q9JIW5, PRO:DNx]
comment: Category=organism-gene.
synonym: "Madh8" RELATED Gene-based [UniProtKB:Q9JIW5]
synonym: "Madh9" RELATED Gene-based [UniProtKB:Q9JIW5]
synonym: "Smad8" RELATED Gene-based [UniProtKB:Q9JIW5]
synonym: "Smad9" RELATED Gene-based [UniProtKB:Q9JIW5]
synonym: "mSMAD9" EXACT PRO-short-label [PRO:DNx]
synonym: "SMAD 9 (mouse)" EXACT [UniProtKB:Q9JIW5]
synonym: "MAD homolog 9 (mouse)" EXACT [UniProtKB:Q9JIW5]
synonym: "SMAD family member 9 (mouse)" EXACT [UniProtKB:Q9JIW5]
synonym: "mothers against DPP homolog 9 (mouse)" EXACT [UniProtKB:Q9JIW5]
xref: UniProtKB:Q9JIW5
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000375 ! smad9
relationship: has_gene_template MGI:1859993 ! Smad9 (mouse)

[Term]
id: PR:000028350
name: smad9 isoform 3 phosphorylated 1 (human)
def: "A smad9 isoform 3 phosphorylated 1 in human. UniProtKB:O15198-1, Ser-465/Ser-467, MOD:00046." [PRO:DAN]
comment: Category=organism-modification.
synonym: "hSMAD9/iso:3/Phos:1" EXACT PRO-short-label [PRO:DNx]
synonym: "UniProtKB:O15198-1, Ser-465/Ser-467, MOD:00046" EXACT PRO-proteoform-std [PRO:DNx]
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
intersection_of: PR:000000667 ! smad9 isoform 3 phosphorylated 1
relationship: has_part MOD:00046 ! O-phospho-L-serine

[Term]
id: PR:000000375
name: smad9
def: "A BMP receptor-regulated smad protein that is a translation product of the human SMAD9 gene or a 1:1 ortholog thereof." [PMID:10708948]
comment: Category=gene.
synonym: "MADH6" RELATED Gene-based []
synonym: "MADH9" RELATED Gene-based []
synonym: "Madh6" EXACT []
synonym: "Madh8" RELATED Gene-based []
synonym: "SMAD8" RELATED Gene-based []
synonym: "SMAD9" EXACT PRO-short-label [PRO:DNx]
synonym: "smad8" EXACT []
synonym: "SMAD 9" EXACT []
synonym: "MAD homolog 9" EXACT []
synonym: "SMAD family member 9" EXACT []
synonym: "mothers against DPP homolog 9" EXACT []
is_a: PR:000000038 ! BMP receptor-regulated smad protein