[Term]
id: PR:A2ARP9
name: cation channel sperm-associated protein 2 (mouse)
def: "A cation channel sperm-associated protein 2 that is encoded in the genome of mouse." [OMA:A2ARP9, PRO:DNx]
comment: Category=organism-gene.
synonym: "Catsper2" RELATED Gene-based [UniProtKB:A2ARP9]
synonym: "mCATSPER2" EXACT PRO-short-label [PRO:DNx]
synonym: "CatSper2 (mouse)" EXACT [UniProtKB:A2ARP9]
xref: UniProtKB:A2ARP9
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000670 ! cation channel sperm-associated protein 2
relationship: has_gene_template MGI:2387404 ! Catsper2 (mouse)

[Term]
id: PR:A2ARP9-1
name: cation channel sperm-associated protein 2 isoform m1 (mouse)
def: "A cation channel sperm-associated protein 2 isoform m1 that is encoded in the genome of mouse." [PRO:CNA]
comment: Category=organism-sequence.
synonym: "mCATSPER2/iso:m1" EXACT PRO-short-label [PRO:DNx]
xref: UniProtKB:A2ARP9-1
intersection_of: only_in_taxon NCBITaxon:10090 ! Mus musculus
intersection_of: PR:000000692 ! cation channel sperm-associated protein 2 isoform m1

[Term]
id: PR:000000670
name: cation channel sperm-associated protein 2
def: "A CatSper channel protein that is a translation product of the human CATSPER2 gene or a 1:1 ortholog thereof. In mammals, four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel. CatSper channels seem to require auxiliary subunits, such as CatSperB (PR:000000672). In common with other channels, CatSper2 proteins have an architecture consisting of six transmembrane domains (S1-S6), arranged in a voltage sensor (S1-S4) and pore modules (S5-P-S6), and with both N and C termini on the intracellular side of the membrane." [PRO:CNA]
comment: Category=gene.
synonym: "CATSPER2" EXACT PRO-short-label [PRO:DNx]
synonym: "CatSper2" EXACT []
xref: IUPHARobj:389
is_a: PR:000044645 ! CatSper channel protein